Maintaining Bilateral Symmetry and Terminal Development in Early Drosophila Embryogenesis- [electronic resource]
Maintaining Bilateral Symmetry and Terminal Development in Early Drosophila Embryogenesis- [electronic resource]
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100443
- ISBN
- 9798379718701
- DDC
- 574
- 저자명
- Smits, Celia M.
- 서명/저자
- Maintaining Bilateral Symmetry and Terminal Development in Early Drosophila Embryogenesis - [electronic resource]
- 발행사항
- [S.l.]: : Princeton University., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(103 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Includes supplementary digital materials.
- 주기사항
- Advisor: Shvartsman, Stanislav Y.
- 학위논문주기
- Thesis (Ph.D.)--Princeton University, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Bilateral symmetry defines much of the animal kingdom and is crucial for numerous functions of bilaterian organisms. Genetic approaches have discovered highly conserved patterning networks that establish bilateral symmetry in early embryos (Genikhovich & Technau, 2017), but how this symmetry is maintained throughout subsequent morphogenetic events remains largely unknown (Grimes, 2019). Here I show that the terminal patterning system - which relies on Ras/ERK signaling through activation of the Torso receptor by its ligand Trunk (Smits & Shvartsman, 2020) - is critical for preserving bilateral symmetry during Drosophila body axis elongation, a process driven by cell rearrangements in the two identical lateral regions of the embryo and specified by the dorsal-ventral and anterior-posterior patterning systems (Kong et al., 2017). I demonstrate that fluctuating asymmetries in this rapid convergent-extension process are attenuated in normal embryos over time, possibly through noise-dissipating forces from the posterior midgut invagination and movement. However, when Torso signaling is attenuated via mutation of Trunk or RNAi directed against downstream Ras/ERK pathway components, body axis elongation results in a characteristic corkscrew phenotype (Perkins et al., 1992), which reflects dramatic reorganization of global tissue flow and is incompatible with viability. These results reveal a new function downstream of the Drosophila terminal patterning system in potentially active control of bilateral symmetry and should motivate systematic search for similar symmetry-preserving regulatory mechanisms in other bilaterians. Additionally, I present a framework for imaging the lineages of pole cell, the primordial germ cells of the embryo, and I show preliminary data on these lineage traces that depicts pole cell division patterns.
- 일반주제명
- Developmental biology.
- 일반주제명
- Cellular biology.
- 일반주제명
- Molecular biology.
- 일반주제명
- Genetics.
- 키워드
- Drosophila
- 키워드
- Embryo
- 기타저자
- Princeton University Molecular Biology
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
detalle info
- Reserva
- No existe
- Mi carpeta
- Primera solicitud
- 비도서대출신청
- 야간 도서대출신청
로그인 후 이용 가능합니다.