Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day- [electronic resource]
Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day- [electronic resource]
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101238
- ISBN
- 9798380384599
- DDC
- 574
- 서명/저자
- Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day - [electronic resource]
- 발행사항
- [S.l.]: : University of Pennsylvania., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(135 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
- 주기사항
- Advisor: Lazar, Mitchell A.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약In this thesis the reader will find a body of work that describes new and exciting data about the nuclear receptors REV-ERBaα and REV-ERBβ. REV-ERBs are interesting proteins to understand because they play important roles in the circadian clock and in the regulation of metabolism on a variety of tissues. Understanding how a factor can link both the clock and metabolism could be the key to understanding the negative effects that circadian misalginment has on metabolic and overall health. In chapter 1 we describe the current knowledge of REV-ERBs and their known roles in the circadian clock and metabolism. We also point out the main aims of this project in understanding what proteins and protein complexes does REV-ERB interact with in order to regulate metabolic and clock genes in a tissue specific manner. In chapter 2 we describe our methodology and the preliminary findings of our proteomics data. In chapter 3 we dive into our first target for follow up the discovery that the HDAC1/SIN3a complex interacts with REV-ERB. In chapter 4 we delve into the second novel finding that REV-ERBα gets SUMOylated in a rhythmic manner. Finally we discovered that REV-ERBs play an important role in the regulation of SUMO3 expression in the liver.
- 일반주제명
- Biochemistry.
- 일반주제명
- Biology.
- 일반주제명
- Biophysics.
- 키워드
- Circadian clock
- 키워드
- Proteomics
- 키워드
- REV-ERBs
- 키워드
- SUMO3 expression
- 기타저자
- University of Pennsylvania Biochemistry and Molecular Biophysics
- 기본자료저록
- Dissertations Abstracts International. 85-03B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
