Understanding the Role of Neuroendocrine Cells in Prostate Carcinogenesis- [electronic resource]
Understanding the Role of Neuroendocrine Cells in Prostate Carcinogenesis- [electronic resource]
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100348
- ISBN
- 9798379713256
- DDC
- 574
- 저자명
- Danysh, Abetov.
- 서명/저자
- Understanding the Role of Neuroendocrine Cells in Prostate Carcinogenesis - [electronic resource]
- 발행사항
- [S.l.]: : Cornell University., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(132 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Advisor: Nikitin, Alexander.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Prostate cancer is the most frequently diagnosed malignancy in men. Commonly used androgen deprivation therapies lead to the development of highly aggressive castrationresistant neuroendocrine prostate carcinomas (NEPC). NEPCs carry frequent alterations in genes such as MYCN, PTEN, TP53, and RB1. Recent studies showed that the plasticity of mouse prostate tumor cells may lead to de-novo neuroendocrine (NE) differentiation. Such observations are supported by mouse models based on the prostate epithelium-specific loss of Pten and Rb1, especially in conjunction with MYCN overexpression. At the same time, some NEPCs may develop from cells showing features of luminal and neuroendocrine cell differentiation, such as in the case of Trp53 and Rb1 inactivation. Using single-cell transcriptomic analysis, I show that NEPC cells deficient for Trp53 and Rb1 have distinct and similar cell subpopulations compared to NEPC associated with concomitant loss Pten and Rb1 and MYCN overexpression. This work provides the basis for future studies to understand how the differences in target cell populations may determine the mechanisms driving the initiation and clinical behavior of NEPCs. Determining the cellular heterogeneity of NEPCs should also allow the stratification of human NEPC into clinically distinct groups and contribute to the development of more effective NEPC treatment strategies.
- 일반주제명
- Molecular biology.
- 일반주제명
- Cellular biology.
- 일반주제명
- Oncology.
- 키워드
- Prostate cancer
- 키워드
- Plasticity
- 키워드
- Neuroendocrine
- 키워드
- NEPC treatment
- 기타저자
- Cornell University Biochemistry Molecular and Cell Biology
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.