Engineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design- [electronic resource]
Engineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design- [electronic resource]
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101212
- ISBN
- 9798379906849
- DDC
- 574
- 저자명
- Dosey, Anne.
- 서명/저자
- Engineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design - [electronic resource]
- 발행사항
- [S.l.]: : University of Washington., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(70 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- 주기사항
- Advisor: King, Neil P.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Protein nanoparticle-based vaccines are a promising platform, shown to be efficacious in preventing disease against a variety of pathogens. Building on their success, increasing our understanding of how nanoparticle vaccines elicit immune responses will aid both in our general understanding of immunology and also in designing improved vaccines. This work centers on influenza hemagglutinin (HA) nanoparticle vaccine design. It starts with the design of HA 'trihead' nanoparticle vaccines, that incorporate several layers of immune refocusing to increase breadth and potency in responses elicited against the HA head. Trihead design was then adapted onto several strains of HA, with the ultimate goal of creating a new platform for seasonal influenza vaccines. Lastly, the interaction of antibodies and HA ectodomain nanoparticles was explored as a means to elucidate mechanisms of their immunogenicity.
- 일반주제명
- Biochemistry.
- 일반주제명
- Pathology.
- 일반주제명
- Nanoscience.
- 일반주제명
- Immunology.
- 키워드
- Antibodies
- 키워드
- Immune responses
- 기타저자
- University of Washington Biochemistry
- 기본자료저록
- Dissertations Abstracts International. 85-01B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
