Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults- [electronic resource]
Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults- [electronic resource]
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100104
- ISBN
- 9798379911812
- DDC
- 610.73
- 서명/저자
- Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults - [electronic resource]
- 발행사항
- [S.l.]: : University of Washington., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(129 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- 주기사항
- Advisor: Heitkemper, Margaret M.;Buchanan, Diana T.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Cyclic vomiting syndrome is a rare debilitating illness which is stereotypical to the patient, has an unclear etiology, no biomarkers for diagnosis, and a varied course of illness. The syndrome was first recognized in pediatric patients, and in that population the symptoms generally resolve in puberty, or in a sub-set of those patients continue on into adulthood as a migraine syndrome. Over the past few decades, however, adult cyclic vomiting syndrome has become increasingly recognized with an established set of diagnostic criteria and guidelines for treatment. However, these guidelines and treatment recommendations are based primarily on published case series data and expert opinions, with a very limited number of randomized clinical trials, as well as a correspondingly few systemic reviews or metanalysis of those trials. There have been no prospective longitudinal studies of adult cyclic vomiting patients, and only a few retrospective chart reviews. Overall, however, the gastroenterological literature has been successfully accumulating data around adult cyclic vomiting syndrome as something similar, but distinct from pediatric cyclic vomiting. Then, in 2004, a research group out of South Australia published a case series of 9 patients with chronic daily cannabis use and a relatively classic cyclic vomiting syndrome. They initially identified 19 similar cases, but 5 refused consent, and 5 were excluded on the basis confounders. Of the remaining 9 patients, 8 displayed an affinity for hot water bathing during episodes of active illness, and 2 were able to remain illness free by abstaining from cannabis. They called their newly identified syndrome 'cannabinoid hyperemesis,' and the subsequent two decades the literature witnessed a significant publication interest in the syndrome. Cannabinoid hyperemesis coincided temporally with the decriminalization and legalization of recreational cannabis use in Europe and the Americas. Several elements around this first publication of cannabinoid hyperemesis are particularly interesting. First, the syndrome is counter-intuitive, as delta-9-tetrahydrocannabinol (the primary psychoactive molecule of the cannabis plant) has been a U.S. FDA approved pharmaceutical as an antiemetic and an appetite stimulant since 1985. Second, there was the peculiar behavior of hot water bathing reported in 90% of the sample. Third, the syndrome seemed to mimic cyclic vomiting syndrome. Finally, despite the severity and chronicity of illness expressed by these individuals with cannabinoid hyperemesis, only 2 out of 9 (22%) were able to successfully abstain from cannabis, the causative agent of their illness. Yet this is supported by the literature on cannabis use disorders which is replete with the difficulties in maintaining cannabis abstinence in patients who have fallen into problematic use. Significantly more information is needed on cannabinoid hyperemesis, cannabis use, and cyclic vomiting syndrome. This 2-paper dissertation moves the field of adult cyclic vomiting syndrome and cannabinoid hyperemesis (herein referred to as cannabis hyperemesis syndrome) forward. Presented first is an in-depth narrative review of literature involving both adult cyclic vomiting syndrome and cannabis hyperemesis syndrome. Second is a retrospective chart review (original research) describing the clinical characteristics of 130 cyclic vomiting patients seen at a specialty center within a tertiary care facility in the Pacific Northwest of the United States.
- 일반주제명
- Nursing.
- 일반주제명
- Health sciences.
- 일반주제명
- French literature.
- 일반주제명
- Pathology.
- 키워드
- Cannabis
- 키워드
- Coalescence
- 키워드
- Opioids
- 기타저자
- University of Washington Nursing
- 기본자료저록
- Dissertations Abstracts International. 85-01B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
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