Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day- [electronic resource]
Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day- [electronic resource]
- Material Type
- 단행본
- 0016933370
- Date and Time of Latest Transaction
- 20240214101238
- ISBN
- 9798380384599
- DDC
- 574
- Author
- Zundell, Delaine M.
- Title/Author
- Understanding Hepatic REV-ERBα Interacting Partners as It Peaks and Troughs Through the Circadian Day - [electronic resource]
- Publish Info
- [S.l.]: : University of Pennsylvania., 2023
- Publish Info
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- Material Info
- 1 online resource(135 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
- General Note
- Advisor: Lazar, Mitchell A.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2023.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Abstracts/Etc
- 요약In this thesis the reader will find a body of work that describes new and exciting data about the nuclear receptors REV-ERBaα and REV-ERBβ. REV-ERBs are interesting proteins to understand because they play important roles in the circadian clock and in the regulation of metabolism on a variety of tissues. Understanding how a factor can link both the clock and metabolism could be the key to understanding the negative effects that circadian misalginment has on metabolic and overall health. In chapter 1 we describe the current knowledge of REV-ERBs and their known roles in the circadian clock and metabolism. We also point out the main aims of this project in understanding what proteins and protein complexes does REV-ERB interact with in order to regulate metabolic and clock genes in a tissue specific manner. In chapter 2 we describe our methodology and the preliminary findings of our proteomics data. In chapter 3 we dive into our first target for follow up the discovery that the HDAC1/SIN3a complex interacts with REV-ERB. In chapter 4 we delve into the second novel finding that REV-ERBα gets SUMOylated in a rhythmic manner. Finally we discovered that REV-ERBs play an important role in the regulation of SUMO3 expression in the liver.
- Subject Added Entry-Topical Term
- Biochemistry.
- Subject Added Entry-Topical Term
- Biology.
- Subject Added Entry-Topical Term
- Biophysics.
- Index Term-Uncontrolled
- Circadian clock
- Index Term-Uncontrolled
- Proteomics
- Index Term-Uncontrolled
- REV-ERBs
- Index Term-Uncontrolled
- SUMO3 expression
- Index Term-Uncontrolled
- Protein complexes
- Added Entry-Corporate Name
- University of Pennsylvania Biochemistry and Molecular Biophysics
- Host Item Entry
- Dissertations Abstracts International. 85-03B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
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- 소장사항
-
202402 2024
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