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Development and Validation of Models to Predict Hypertension in Latin Americans- [electronic resource]
Development and Validation of Models to Predict Hypertension in Latin Americans - [electro...
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Development and Validation of Models to Predict Hypertension in Latin Americans- [electronic resource]
자료유형  
 학위논문파일 국외
최종처리일시  
20240214101240
ISBN  
9798379719654
DDC  
614.4
저자명  
Bajwa, Pravleen K.
서명/저자  
Development and Validation of Models to Predict Hypertension in Latin Americans - [electronic resource]
발행사항  
[S.l.]: : The University of Wisconsin - Madison., 2023
발행사항  
Ann Arbor : : ProQuest Dissertations & Theses,, 2023
형태사항  
1 online resource(138 p.)
주기사항  
Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
주기사항  
Advisor: Bautista, Leonelo.
학위논문주기  
Thesis (Ph.D.)--The University of Wisconsin - Madison, 2023.
사용제한주기  
This item must not be sold to any third party vendors.
초록/해제  
요약Blood pressure (BP) prediction models can be useful for identifying individuals at high risk for developing hypertension. However, using models developed in a population with different underlying characteristics can under- or over-estimate the risk. Currently, no BP prediction models have been developed for Latin Americans. Additionally, all current models predicting high BP dichotomize BP instead of predicting continuous systolic (SBP) or diastolic (DBP) blood pressure. This can lead to loss of information and statistical power and relies on predefined BP cut-points to define hypertension. In this dissertation, we start with a systematic literature review of studies that developed or externally validated models predicting hypertension risk or another BP-related outcome. Then, we develop a model to predict the risk of incident hypertension in a Latin American population (Colombia). Finally, we develop a model to predict future SBP and DBP in the same population. We found that most existing models showed a high risk of bias due to limitations in the analyses. Our binary model had good discrimination but over-predicted the risk of hypertension in some deciles of predicted risk. Our continuous model showed better agreement over deciles of predicted BP. However, it tended to under-predict the BP in the higher and lower tails of the BP distribution. Overall, we created two high BP prediction models for Colombian adults and recommend the use of the continuous model. We also share user-friendly nomograms for both models to facilitate convenient predictions.
일반주제명  
Epidemiology.
일반주제명  
Public health.
일반주제명  
Biostatistics.
키워드  
Blood pressure
키워드  
Calibration
키워드  
Discrimination
키워드  
Hypertension
키워드  
Model validation
키워드  
Prediction modeling
기타저자  
The University of Wisconsin - Madison Population Health
기본자료저록  
Dissertations Abstracts International. 84-12B.
기본자료저록  
Dissertation Abstract International
전자적 위치 및 접속  
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