Mucosal-Associated Invariant T Cells in Critical Illness- [electronic resource]
Mucosal-Associated Invariant T Cells in Critical Illness- [electronic resource]
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100119
- ISBN
- 9798380128698
- DDC
- 616.079
- 서명/저자
- Mucosal-Associated Invariant T Cells in Critical Illness - [electronic resource]
- 발행사항
- [S.l.]: : The University of Utah., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(131 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
- 주기사항
- Advisor: Leung, Daniel Ted.
- 학위논문주기
- Thesis (Ph.D.)--The University of Utah, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Systemic critical illnesses, such as burn injury and sepsis, fundamentally and negatively alter the human immune system's ability to defend against pathogens. Severe burn injuries can lead to sepsis, which, if not treated appropriately and in a timely manner, can result in death. Recently it has been suggested that there are 50 million cases of sepsis worldwide, and with advances in medical treatments, the mortality rate from sepsis has decreased from 40-50% to approximately 20% over the past three decades. However, we still lack a firm understanding of the immunological intricacies that cause sepsis and how to effectively treat post-acute sepsis, which can severely weaken the immune system.Our study focuses on conventional αβ T cells and mucosal-associated invariant T (MAIT) cells in human burn injury and acute sepsis. MAIT cells are a unique subset of αβ T cells that express Vα7.2 and can be rapidly activated in a TCR-dependent manner through microbial-derived riboflavin metabolites presented on MR1 proteins by antigen-presenting cells. Recently, studies using a mouse model of skin wound repair have implicated MAIT cells in tissue repair transcriptionally and mechanistically. Due to their timely response to infection and rapid activation, we hypothesize that MAIT cells play an important role in both sepsis and burn injury by aiding in the clearance of infections.In Chapter 2, we explore the characteristics of conventional αβ T cells and MAIT cells in burn injuries of human skin, comparing their phenotypic and functional differences to non-burned skin. Chapter 3 delves into MAIT cells in human acute sepsis and investigates their transcriptional and epigenetic changes that may account for MAIT cell dysfunction. Finally, in Chapter 4, we propose a novel strategy to efficiently target the proliferation of MAIT cells ex vivo, which could potentially serve as a form of immunotherapy for individuals experiencing critical illness. Our research sheds light on the unique features of conventional T cells and MAIT cells in human burn injuries and acute sepsis.
- 일반주제명
- Immunology.
- 일반주제명
- Molecular biology.
- 일반주제명
- Cellular biology.
- 키워드
- Burn injury
- 키워드
- Mucosal barriers
- 키워드
- Sepsis
- 키워드
- Skin immunology
- 키워드
- T cells
- 기타저자
- The University of Utah Pathology
- 기본자료저록
- Dissertations Abstracts International. 85-02B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.