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The Development of a Multi-Contrast Chest X-Ray Radiography (MC-CXR) Prototype System for the Diagnosis of Lung Disease- [electronic resource]
The Development of a Multi-Contrast Chest X-Ray Radiography (MC-CXR) Prototype System for the Diagnosis of Lung Disease- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101214
- ISBN
- 9798379682187
- DDC
- 616
- 저자명
- Bushe, Daniel.
- 서명/저자
- The Development of a Multi-Contrast Chest X-Ray Radiography (MC-CXR) Prototype System for the Diagnosis of Lung Disease - [electronic resource]
- 발행사항
- [S.l.]: : The University of Wisconsin - Madison., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(181 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Advisor: Chen, Guang-Hong.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Chest X-ray radiography (CXR) has long served as the frontline imaging modality deployed for the detection of pulmonary disorders. Despite the modality's widespread clinical utility, the diagnostic efficacy of radiography for the detection and diagnosis of pulmonary diseases is severely hindered by the intrinsic physical limitation of the X-ray absorption contrast mechanism. The early manifestation of many pulmonary disorders involves the destruction, damage, or filling of the alveoli with fluids, immunological agents, and lesions prior to the onset of clinical symptoms. These underlying structural and physiological changes to the pulmonary anatomy result in an increase of X-ray attenuation by only a few percent. The low contrast generated between diseased and healthy pulmonary tissue can be easily obfuscated by the presence of anatomical noise or the superimposition of other anatomical structures along the X-ray beam direction.The aim of this thesis is to construct, optimize, and evaluate a novel multi-contrast chest X-ray radiography prototype system to address the limitations associated with conventional X-ray radiography. Multi-contrast X-ray imaging leverages the wave nature of X-rays to simultaneously generate information regarding the absorption, refraction, and small-angle scattering of X-rays. The small-angle scattering mechanism has demonstrated the capacity to probe the microstructures of the lungs and generate a strong image signal of alveolar air interfaces. However, when the alveoli become filled, damaged, or destroyed, the small-angle scattering signal is extinguished. It is for this reason that multi-contrast X-ray imaging is hypothesized to enhance the utility of X-ray radiography. The first key topic of this thesis work is the design and construction of a clinically compatible multi-contrast prototype system. Following the system construction, a fast scanning beam acquisition scheme is implemented to enable imaging of the entire chest within a single breath-hold. The interferometric and clinical imaging performances are then optimized for a variety of clinical imaging scenarios. To conclude this thesis, the potential for multi-contrast imaging to enhance the diagnostic efficacy of X-ray radiography is evaluated through phantom and animal imaging studies.
- 일반주제명
- Medical imaging.
- 일반주제명
- Physics.
- 일반주제명
- Biomedical engineering.
- 키워드
- Multi-contrast
- 키워드
- X-ray dark field
- 기타저자
- The University of Wisconsin - Madison Medical Physics
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798379682187
■035 ▼a(MiAaPQ)AAI30525860
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aBushe, Daniel.
■24510▼aThe Development of a Multi-Contrast Chest X-Ray Radiography (MC-CXR) Prototype System for the Diagnosis of Lung Disease▼h[electronic resource]
■260 ▼a[S.l.]:▼bThe University of Wisconsin - Madison. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(181 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Chen, Guang-Hong.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aChest X-ray radiography (CXR) has long served as the frontline imaging modality deployed for the detection of pulmonary disorders. Despite the modality's widespread clinical utility, the diagnostic efficacy of radiography for the detection and diagnosis of pulmonary diseases is severely hindered by the intrinsic physical limitation of the X-ray absorption contrast mechanism. The early manifestation of many pulmonary disorders involves the destruction, damage, or filling of the alveoli with fluids, immunological agents, and lesions prior to the onset of clinical symptoms. These underlying structural and physiological changes to the pulmonary anatomy result in an increase of X-ray attenuation by only a few percent. The low contrast generated between diseased and healthy pulmonary tissue can be easily obfuscated by the presence of anatomical noise or the superimposition of other anatomical structures along the X-ray beam direction.The aim of this thesis is to construct, optimize, and evaluate a novel multi-contrast chest X-ray radiography prototype system to address the limitations associated with conventional X-ray radiography. Multi-contrast X-ray imaging leverages the wave nature of X-rays to simultaneously generate information regarding the absorption, refraction, and small-angle scattering of X-rays. The small-angle scattering mechanism has demonstrated the capacity to probe the microstructures of the lungs and generate a strong image signal of alveolar air interfaces. However, when the alveoli become filled, damaged, or destroyed, the small-angle scattering signal is extinguished. It is for this reason that multi-contrast X-ray imaging is hypothesized to enhance the utility of X-ray radiography. The first key topic of this thesis work is the design and construction of a clinically compatible multi-contrast prototype system. Following the system construction, a fast scanning beam acquisition scheme is implemented to enable imaging of the entire chest within a single breath-hold. The interferometric and clinical imaging performances are then optimized for a variety of clinical imaging scenarios. To conclude this thesis, the potential for multi-contrast imaging to enhance the diagnostic efficacy of X-ray radiography is evaluated through phantom and animal imaging studies.
■590 ▼aSchool code: 0262.
■650 4▼aMedical imaging.
■650 4▼aPhysics.
■650 4▼aBiomedical engineering.
■653 ▼aChest X-ray imaging
■653 ▼aMulti-contrast
■653 ▼aPrototype imaging system
■653 ▼aX-ray dark field
■653 ▼aX-ray phase contrast
■653 ▼aChest X-ray radiography
■690 ▼a0574
■690 ▼a0605
■690 ▼a0541
■71020▼aThe University of Wisconsin - Madison▼bMedical Physics.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933185▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
