본문

서브메뉴

Understanding Lower Extremity Symptoms for Improved Detection of Peripheral Artery Disease: The PREDICT PAD Study- [electronic resource]
Understanding Lower Extremity Symptoms for Improved Detection of Peripheral Artery Disease...
Understanding Lower Extremity Symptoms for Improved Detection of Peripheral Artery Disease: The PREDICT PAD Study- [electronic resource]

상세정보

자료유형  
 학위논문파일 국외
최종처리일시  
20240214095857
ISBN  
9798380391795
DDC  
610.73
저자명  
Brown, Rebecca J. L.
서명/저자  
Understanding Lower Extremity Symptoms for Improved Detection of Peripheral Artery Disease: The PREDICT PAD Study - [electronic resource]
발행사항  
[S.l.]: : University of Minnesota., 2021
발행사항  
Ann Arbor : : ProQuest Dissertations & Theses,, 2021
형태사항  
1 online resource(285 p.)
주기사항  
Source: Dissertations Abstracts International, Volume: 85-03, Section: A.
주기사항  
Advisor: Treat-Jacobson, Diane;Schorr, Erica N.
학위논문주기  
Thesis (Ph.D.)--University of Minnesota, 2021.
사용제한주기  
This item must not be sold to any third party vendors.
초록/해제  
요약BackgroundOf all the major manifestations of atherosclerosis, peripheral artery disease (PAD) is one of the most underdiagnosed and undertreated vascular diseases, due, in part, to the large number of individuals who experience atypical symptoms, yet our current screening tools are designed to detect those with classic symptoms. PAD causes functional decline and disability, low quality of life, and increased risk of all-cause mortality and cardiovascular death, therefore there is an immediate need to improve detection methods. AimsThis dissertation is aimed to 1) Comprehensively describe the range of atypical symptom characteristics in individuals with PAD, how atypical symptoms are defined, and examine potential factors associated with atypical symptoms reported in the literature. 2) Identify characteristics that discriminate between PAD and non-PAD in a group of previously undiagnosed individuals with any type of lower extremity symptoms. 3) Measure the effects of exercise on symptom reporting and calf muscle ischemia and 4) elucidate the experience of individuals with undiagnosed PAD and explore differences in symptomatology in those with and without PAD. MethodsAim 1. A critical review of the published literature on symptom description in PAD was conducted with a particular focus on articles delineating classic or typical symptoms from atypical symptoms. Studies were analyzed based on methodological approach including a) questionnaire-based, b) clinician assessment, and c) qualitative interview. The definitions and associated conditions are discussed. Aim 2. One-time study visit was conducted to evaluate lower extremity symptoms at rest, during, and post exercise in adults 60 years and older with persistent lower extremity symptoms, not previously diagnosed with PAD (n = 25). Symptom assessment included validated questionnaires, a symptom adjective checklist, measurement of muscle tissue oxygenation, and an exploratory semi-structured interview. The visit concluded with a diagnostic vascular assessment using the ankle brachial index (ABI) test. Results were analyzed by naturally occurring groups based off the ABI (abnormal vs normal ABI).Aim 3. Symptoms were measured pre and post six-minute walk test to determine whether exercise elicits symptoms that more closely resemble classic PAD symptoms. Muscle tissue oxygen saturation was measured using near infrared spectroscopy to determine differences in recovery time post exercise between the PAD and non-PAD group. Aim 4. A qualitative content analysis of the audio-recorded semi-structured interviews was conducted to gain a deeper understanding of the differences between those with and without PAD and to understand the experience of individuals with undiagnosed PAD. Results Aim 1. Twenty-four articles were included in the review and was comprised of 8,169 unique individuals with PAD, with an average age of 68.0 years (42.3% female). The definition of atypical symptoms varied across the literature, as did the prevalence ranging from 7.9% - 50.3%. Atypical symptoms were more often associated with increased rates of comorbid diseases, coexisting conditions affecting ambulation, and a greater number of PAD risk factors. The majority of participants reported atypical symptoms and as well as interference with activities of daily living, physical function, and social and personal lives.Aim 2. Four questions were statistically significantly different between participants in the PAD group vs. the non-PAD group. Two of the four questions are contrary to the expected findings. The questions that best differentiated PAD from non-PAD were "Do your symptoms disappear while walking?", "Do you have difficulty keeping up with your friends or family?", "Do you have symptoms while sitting?", "Where are your symptoms?". Participants in the PAD group reported that their symptoms did not disappear while walking, they had difficulty keeping up with friends and family, had pain while sitting, and were less likely to experience calf or thigh pain. Aim 3. Exercise did not yield symptoms that more closely resembled classic PAD symptoms. Post exercise, the sensitivity and specificity of the validated screening questionnaires were either unchanged or worse. Participants in the PAD group took longer to recover based off return to normal muscle tissue oxygenation levels. Aim 4. The content analysis revealed eight concepts, two of which were unique to the PAD group. These were: Breath of Physical Findings and Confounding Factors, Coping Strategies, Impact on Activities of Daily Living, Determinants of Behavior, Communication Barriers, Symptoms Threaten, Credibility Feels at Risk (PAD only), and Unexplained Symptoms are Distressing (PAD only). Conclusion This dissertation examined discriminating characteristics of PAD in a sample of participants who were previously undiagnosed. Four screening questions may improve detection of PAD, however there are many communication barriers, atypical symptoms, and overlapping symptoms which continuously plague this approach to screening. Participants with undiagnosed PAD experienced discomfort, social limitations, and were distressed over their symptoms. The results emphasize the need to use definitions that serve to meet the needs of the patients who experience them. A broader definition of claudication beyond classic claudication is needed to improve access to vascular testing and enhance detection of PAD.
일반주제명  
Nursing.
일반주제명  
Health education.
일반주제명  
Surgery.
키워드  
Detection
키워드  
Diagnostic accuracy
키워드  
Peripheral artery disease
키워드  
Symptomatology
기타저자  
University of Minnesota Nursing
기본자료저록  
Dissertations Abstracts International. 85-03A.
기본자료저록  
Dissertation Abstract International
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

 008240612s2021      us  |||||||||||||||c||eng  d
■001000016931032
■00520240214095857
■006m          o    d                
■007cr#unu||||||||
■020    ▼a9798380391795
■035    ▼a(MiAaPQ)AAI28720941
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a610.73
■1001  ▼aBrown,  Rebecca  J.  L.
■24510▼aUnderstanding  Lower  Extremity  Symptoms  for  Improved  Detection  of  Peripheral  Artery  Disease:  The  PREDICT  PAD  Study▼h[electronic  resource]
■260    ▼a[S.l.]:▼bUniversity  of  Minnesota.  ▼c2021
■260  1▼aAnn  Arbor  :▼bProQuest  Dissertations  &  Theses,  ▼c2021
■300    ▼a1  online  resource(285  p.)
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-03,  Section:  A.
■500    ▼aAdvisor:  Treat-Jacobson,  Diane;Schorr,  Erica    N.
■5021  ▼aThesis  (Ph.D.)--University  of  Minnesota,  2021.
■506    ▼aThis  item  must  not  be  sold  to  any  third  party  vendors.
■520    ▼aBackgroundOf  all  the  major  manifestations  of  atherosclerosis,  peripheral  artery  disease  (PAD)  is  one  of  the  most  underdiagnosed  and  undertreated  vascular  diseases,  due,  in  part,  to  the  large  number  of  individuals  who  experience  atypical  symptoms,  yet  our  current  screening  tools  are  designed  to  detect  those  with  classic  symptoms.  PAD  causes  functional  decline  and  disability,  low  quality  of  life,  and  increased  risk  of  all-cause  mortality  and  cardiovascular  death,  therefore  there  is  an  immediate  need  to  improve  detection  methods.  AimsThis  dissertation  is  aimed  to  1)  Comprehensively  describe  the  range  of  atypical  symptom  characteristics  in  individuals  with  PAD,  how  atypical  symptoms  are  defined,  and  examine  potential  factors  associated  with  atypical  symptoms  reported  in  the  literature.  2)  Identify  characteristics  that  discriminate  between  PAD  and  non-PAD  in  a  group  of  previously  undiagnosed  individuals  with  any  type  of  lower  extremity  symptoms.  3)  Measure  the  effects  of  exercise  on  symptom  reporting  and  calf  muscle  ischemia  and  4)  elucidate  the  experience  of  individuals  with  undiagnosed  PAD  and  explore  differences  in  symptomatology  in  those  with  and  without  PAD.  MethodsAim  1.  A  critical  review  of  the  published  literature  on  symptom  description  in  PAD  was  conducted  with  a  particular  focus  on  articles  delineating  classic  or  typical  symptoms  from  atypical  symptoms.  Studies  were  analyzed  based  on  methodological  approach  including  a)  questionnaire-based,  b)  clinician  assessment,  and  c)  qualitative  interview.  The  definitions  and  associated  conditions  are  discussed.  Aim  2.  One-time  study  visit  was  conducted  to  evaluate  lower  extremity  symptoms  at  rest,  during,  and  post  exercise  in  adults  60  years  and  older  with  persistent  lower  extremity  symptoms,  not  previously  diagnosed  with  PAD  (n  =  25).  Symptom  assessment  included  validated  questionnaires,  a  symptom  adjective  checklist,  measurement  of  muscle  tissue  oxygenation,  and  an  exploratory  semi-structured  interview.  The  visit  concluded  with  a  diagnostic  vascular  assessment  using  the  ankle  brachial  index  (ABI)  test.  Results  were  analyzed  by  naturally  occurring  groups  based  off  the  ABI  (abnormal  vs  normal  ABI).Aim  3.  Symptoms  were  measured  pre  and  post  six-minute  walk  test  to  determine  whether  exercise  elicits  symptoms  that  more  closely  resemble  classic  PAD  symptoms.  Muscle  tissue  oxygen  saturation  was  measured  using  near  infrared  spectroscopy  to  determine  differences  in  recovery  time  post  exercise  between  the  PAD  and  non-PAD  group.  Aim  4.  A  qualitative  content  analysis  of  the  audio-recorded  semi-structured  interviews  was  conducted  to  gain  a  deeper  understanding  of  the  differences  between  those  with  and  without  PAD  and  to  understand  the  experience  of  individuals  with  undiagnosed  PAD.  Results  Aim  1.  Twenty-four  articles  were  included  in  the  review  and  was  comprised  of  8,169  unique  individuals  with  PAD,  with  an  average  age  of  68.0  years  (42.3%  female).  The  definition  of  atypical  symptoms  varied  across  the  literature,  as  did  the  prevalence  ranging  from  7.9%  -  50.3%.  Atypical  symptoms  were  more  often  associated  with  increased  rates  of  comorbid  diseases,  coexisting  conditions  affecting  ambulation,  and  a  greater  number  of  PAD  risk  factors.  The  majority  of  participants  reported  atypical  symptoms  and  as  well  as  interference  with  activities  of  daily  living,  physical  function,  and  social  and  personal  lives.Aim  2.  Four  questions  were  statistically  significantly  different  between  participants  in  the  PAD  group  vs.  the  non-PAD  group.  Two  of  the  four  questions  are  contrary  to  the  expected  findings.  The  questions  that  best  differentiated  PAD  from  non-PAD  were  "Do  your  symptoms  disappear  while  walking?",  "Do  you  have  difficulty  keeping  up  with  your  friends  or  family?",  "Do  you  have  symptoms  while  sitting?",  "Where  are  your  symptoms?".  Participants  in  the  PAD  group  reported  that  their  symptoms  did  not  disappear  while  walking,  they  had  difficulty  keeping  up  with  friends  and  family,  had  pain  while  sitting,  and  were  less  likely  to  experience  calf  or  thigh  pain.  Aim  3.  Exercise  did  not  yield  symptoms  that  more  closely  resembled  classic  PAD  symptoms.  Post  exercise,  the  sensitivity  and  specificity  of  the  validated  screening  questionnaires  were  either  unchanged  or  worse.  Participants  in  the  PAD  group  took  longer  to  recover  based  off  return  to  normal  muscle  tissue  oxygenation  levels.  Aim  4.  The  content  analysis  revealed  eight  concepts,  two  of  which  were  unique  to  the  PAD  group.  These  were:  Breath  of  Physical  Findings  and  Confounding  Factors,  Coping  Strategies,  Impact  on  Activities  of  Daily  Living,  Determinants  of  Behavior,  Communication  Barriers,  Symptoms  Threaten,  Credibility  Feels  at  Risk  (PAD  only),  and  Unexplained  Symptoms  are  Distressing  (PAD  only).  Conclusion  This  dissertation  examined  discriminating  characteristics  of  PAD  in  a  sample  of  participants  who  were  previously  undiagnosed.  Four  screening  questions  may  improve  detection  of  PAD,  however  there  are  many  communication  barriers,  atypical  symptoms,  and  overlapping  symptoms  which  continuously  plague  this  approach  to  screening.  Participants  with  undiagnosed  PAD  experienced  discomfort,  social  limitations,  and  were  distressed  over  their  symptoms.  The  results  emphasize  the  need  to  use  definitions  that  serve  to  meet  the  needs  of  the  patients  who  experience  them.  A  broader  definition  of  claudication  beyond  classic  claudication  is  needed  to  improve  access  to  vascular  testing  and  enhance  detection  of  PAD.
■590    ▼aSchool  code:  0130.
■650  4▼aNursing.
■650  4▼aHealth  education.
■650  4▼aSurgery.
■653    ▼aDetection
■653    ▼aDiagnostic  accuracy
■653    ▼aPeripheral  artery  disease
■653    ▼aSymptomatology
■690    ▼a0569
■690    ▼a0576
■690    ▼a0680
■71020▼aUniversity  of  Minnesota▼bNursing.
■7730  ▼tDissertations  Abstracts  International▼g85-03A.
■773    ▼tDissertation  Abstract  International
■790    ▼a0130
■791    ▼aPh.D.
■792    ▼a2021
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931032▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.
■980    ▼a202402▼f2024

미리보기

내보내기

chatGPT토론

Ai 추천 관련 도서


    신착도서 더보기
    최근 3년간 통계입니다.

    소장정보

    • 예약
    • 소재불명신고
    • 나의폴더
    • 우선정리요청
    • 비도서대출신청
    • 야간 도서대출신청
    소장자료
    등록번호 청구기호 소장처 대출가능여부 대출정보
    TF05746 전자도서 마이폴더 부재도서신고 비도서대출신청

    * 대출중인 자료에 한하여 예약이 가능합니다. 예약을 원하시면 예약버튼을 클릭하십시오.

    해당 도서를 다른 이용자가 함께 대출한 도서

    관련 인기도서

    로그인 후 이용 가능합니다.