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Maturation of the Endocannabinoid System in the Medial Prefrontal Cortex and the Effect of Perinatal Cananbinoid Exposure- [electronic resource]
Maturation of the Endocannabinoid System in the Medial Prefrontal Cortex and the Effect of Perinatal Cananbinoid Exposure- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101925
- ISBN
- 9798380851473
- DDC
- 616
- 서명/저자
- Maturation of the Endocannabinoid System in the Medial Prefrontal Cortex and the Effect of Perinatal Cananbinoid Exposure - [electronic resource]
- 발행사항
- [S.l.]: : Indiana University., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(81 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
- 주기사항
- Advisor: Mackie, Kenneth.
- 학위논문주기
- Thesis (Ph.D.)--Indiana University, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약The endocannabinoid system (ECS) is a widespread neuromodulatory system that is present from early stages of prenatal development and plays a critical role in central nervous system development. Additionally, the ECS also mediates the effects of exogenous cannabinoids, like delta-9-tetrahydrocannabinol (THC), the primary psychoactive/intoxicating component of cannabis. Therefore, early life cannabinoid exposure, through inappropriate activation of the ECS, could have severe effects on the immature brain and the development of neural circuitry. Furthermore, cannabis is the most widely used illicit drug in the United States with usage increasing in correlation with increasing legalization of medical and recreational cannabis use. Therefore, understanding the effects of cannabis use across all age ranges is of increasing relevance and importance. As cannabis use is widely perceived as less harmful in comparison to other drugs of abuse, there is a growing population of women who continue to use cannabis throughout their pregnancies and during lactation. However, the impact of this drug exposure on the offspring's neurodevelopment is still unknown, but adverse effects are strongly suggested due to findings that exogenous cannabinoids, like THC, can cross the placenta and are found in breast milk. Early studies have found an association between cannabis use during pregnancy and increased rates of stillbirth and preterm birth as well as impairments in fetal growth and cognitive function. Furthermore, the perinatal period of development, the time immediately before and after birth, is a critical period of neurological development and is especially vulnerable to adverse effects due to early life cannabis exposure. During this time GABA transitions from its immature excitatory state to its mature inhibitory state due to an increased expression of the KCC2 K+/Cl- co-transporter. Alterations in the timing of the GABA switch could have far-reaching effects on the functioning of the central nervous system and may lead to neurological disorders. The research conducted within this dissertation can be divided into three main projects: 1) the effect of in-utero cannabinoid exposure on cortical function in the mPFC, 2) the effect of perinatal cannabinoid exposure on KCC2 and the GABA switch, and 3) sex-specific developmental changes to the mPFC and key molecules of the endocannabinoid system.
- 일반주제명
- Neurosciences.
- 일반주제명
- Psychology.
- 일반주제명
- Developmental biology.
- 키워드
- Cannabinoids
- 키워드
- Neural circuitry
- 키워드
- Perinatal period
- 기타저자
- Indiana University Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 85-05B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101925
■006m o d
■007cr#unu||||||||
■020 ▼a9798380851473
■035 ▼a(MiAaPQ)AAI30694826
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aMurphy Green, Michelle.
■24510▼aMaturation of the Endocannabinoid System in the Medial Prefrontal Cortex and the Effect of Perinatal Cananbinoid Exposure▼h[electronic resource]
■260 ▼a[S.l.]:▼bIndiana University. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(81 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-05, Section: B.
■500 ▼aAdvisor: Mackie, Kenneth.
■5021 ▼aThesis (Ph.D.)--Indiana University, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aThe endocannabinoid system (ECS) is a widespread neuromodulatory system that is present from early stages of prenatal development and plays a critical role in central nervous system development. Additionally, the ECS also mediates the effects of exogenous cannabinoids, like delta-9-tetrahydrocannabinol (THC), the primary psychoactive/intoxicating component of cannabis. Therefore, early life cannabinoid exposure, through inappropriate activation of the ECS, could have severe effects on the immature brain and the development of neural circuitry. Furthermore, cannabis is the most widely used illicit drug in the United States with usage increasing in correlation with increasing legalization of medical and recreational cannabis use. Therefore, understanding the effects of cannabis use across all age ranges is of increasing relevance and importance. As cannabis use is widely perceived as less harmful in comparison to other drugs of abuse, there is a growing population of women who continue to use cannabis throughout their pregnancies and during lactation. However, the impact of this drug exposure on the offspring's neurodevelopment is still unknown, but adverse effects are strongly suggested due to findings that exogenous cannabinoids, like THC, can cross the placenta and are found in breast milk. Early studies have found an association between cannabis use during pregnancy and increased rates of stillbirth and preterm birth as well as impairments in fetal growth and cognitive function. Furthermore, the perinatal period of development, the time immediately before and after birth, is a critical period of neurological development and is especially vulnerable to adverse effects due to early life cannabis exposure. During this time GABA transitions from its immature excitatory state to its mature inhibitory state due to an increased expression of the KCC2 K+/Cl- co-transporter. Alterations in the timing of the GABA switch could have far-reaching effects on the functioning of the central nervous system and may lead to neurological disorders. The research conducted within this dissertation can be divided into three main projects: 1) the effect of in-utero cannabinoid exposure on cortical function in the mPFC, 2) the effect of perinatal cannabinoid exposure on KCC2 and the GABA switch, and 3) sex-specific developmental changes to the mPFC and key molecules of the endocannabinoid system.
■590 ▼aSchool code: 0093.
■650 4▼aNeurosciences.
■650 4▼aPsychology.
■650 4▼aDevelopmental biology.
■653 ▼aCannabinoids
■653 ▼aNeural circuitry
■653 ▼aMedial prefrontal cortex
■653 ▼aPerinatal period
■690 ▼a0317
■690 ▼a0621
■690 ▼a0758
■71020▼aIndiana University▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g85-05B.
■773 ▼tDissertation Abstract International
■790 ▼a0093
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16935378▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
