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Charting Neurodevelopment Along a Sensorimotor-Association Cortical Axis: Patterns of Plasticity, Environmental Susceptibility, and Psychiatric Vulnerability- [electronic resource]
Charting Neurodevelopment Along a Sensorimotor-Association Cortical Axis: Patterns of Plasticity, Environmental Susceptibility, and Psychiatric Vulnerability- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101247
- ISBN
- 9798380388498
- DDC
- 616
- 서명/저자
- Charting Neurodevelopment Along a Sensorimotor-Association Cortical Axis: Patterns of Plasticity, Environmental Susceptibility, and Psychiatric Vulnerability - [electronic resource]
- 발행사항
- [S.l.]: : University of Pennsylvania., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(318 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
- 주기사항
- Advisor: Satterthwaite, Theodore D.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Human cortical development is protracted, heterochronous, sculpted by the environment, and associated with the emergence of diverse psychiatric conditions. Elucidating how developmental plasticity asynchronously progresses across the cortex is vital for understanding which cortical regions will be impacted by positive and negative environments and psychiatric insults and interventions at distinct developmental stages. Prior research has provided consistent evidence that cortical maturation occurs earlier in sensory and motor cortices and later in association cortices. However, beyond this coarse division in developmental timing between these two domains of cortex, there is marked variability in cortical development that remains undercharacterized-and therefore unaccounted for by contemporary accounts of human brain development. This thesis seeks to put forth a model of child and adolescent cortical maturation that accounts for our species' rich spatiotemporal developmental variability and psychiatric vulnerability. It first reviews existing knowledge concerning human brain development and brain organization and hypothesizes that maturation unfolds along an evolutionarily-rooted, hierarchical, and graded sensorimotor-to-associative axis of cortical organization. It discusses how the unfolding of development along this axis endows transmodal association cortices with both unique neurobiological properties and heightened inter-individual developmental variability and vulnerability. The thesis next leverages a proposed functional signature of plasticity illuminated by animal models to empirically evaluate the hypothesized developmental model. It provides evidence that human cortical development indeed progresses along a sensorimotor-association axis from ages 8 to 18 years and demonstrates how environmental influences on the maturating brain are shaped by this developmental program. Finally, the thesis explores neural correlates of diminished reward responsiveness, a psychiatric risk factor, in a transdiagnostic sample of adolescents and young adults. It shows that this risk factor is dimensionally and selectively associated with lower levels of glutamate within transmodal association cortices and subcortical areas that comprise the brain's reward network. Together, the work presented here may help to inform environmental and psychiatric interventions for youth that incorporate basic principles of developmental plasticity and are delivered while the brain is undergoing demarcated periods of malleability.
- 일반주제명
- Neurosciences.
- 일반주제명
- Developmental biology.
- 일반주제명
- Mental health.
- 일반주제명
- Cellular biology.
- 키워드
- Neurodevelopment
- 키워드
- Plasticity
- 기타저자
- University of Pennsylvania Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 85-03B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101247
■006m o d
■007cr#unu||||||||
■020 ▼a9798380388498
■035 ▼a(MiAaPQ)AAI30529339
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aSydnor, Valerie Jill.
■24510▼aCharting Neurodevelopment Along a Sensorimotor-Association Cortical Axis: Patterns of Plasticity, Environmental Susceptibility, and Psychiatric Vulnerability▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of Pennsylvania. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(318 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-03, Section: B.
■500 ▼aAdvisor: Satterthwaite, Theodore D.
■5021 ▼aThesis (Ph.D.)--University of Pennsylvania, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aHuman cortical development is protracted, heterochronous, sculpted by the environment, and associated with the emergence of diverse psychiatric conditions. Elucidating how developmental plasticity asynchronously progresses across the cortex is vital for understanding which cortical regions will be impacted by positive and negative environments and psychiatric insults and interventions at distinct developmental stages. Prior research has provided consistent evidence that cortical maturation occurs earlier in sensory and motor cortices and later in association cortices. However, beyond this coarse division in developmental timing between these two domains of cortex, there is marked variability in cortical development that remains undercharacterized-and therefore unaccounted for by contemporary accounts of human brain development. This thesis seeks to put forth a model of child and adolescent cortical maturation that accounts for our species' rich spatiotemporal developmental variability and psychiatric vulnerability. It first reviews existing knowledge concerning human brain development and brain organization and hypothesizes that maturation unfolds along an evolutionarily-rooted, hierarchical, and graded sensorimotor-to-associative axis of cortical organization. It discusses how the unfolding of development along this axis endows transmodal association cortices with both unique neurobiological properties and heightened inter-individual developmental variability and vulnerability. The thesis next leverages a proposed functional signature of plasticity illuminated by animal models to empirically evaluate the hypothesized developmental model. It provides evidence that human cortical development indeed progresses along a sensorimotor-association axis from ages 8 to 18 years and demonstrates how environmental influences on the maturating brain are shaped by this developmental program. Finally, the thesis explores neural correlates of diminished reward responsiveness, a psychiatric risk factor, in a transdiagnostic sample of adolescents and young adults. It shows that this risk factor is dimensionally and selectively associated with lower levels of glutamate within transmodal association cortices and subcortical areas that comprise the brain's reward network. Together, the work presented here may help to inform environmental and psychiatric interventions for youth that incorporate basic principles of developmental plasticity and are delivered while the brain is undergoing demarcated periods of malleability.
■590 ▼aSchool code: 0175.
■650 4▼aNeurosciences.
■650 4▼aDevelopmental biology.
■650 4▼aMental health.
■650 4▼aCellular biology.
■653 ▼aAdolescent psychopathology
■653 ▼aCortical organization
■653 ▼aNeurodevelopment
■653 ▼aPlasticity
■653 ▼aSensorimotor-association axis
■653 ▼aSocioeconomic gradient
■690 ▼a0317
■690 ▼a0758
■690 ▼a0347
■690 ▼a0379
■71020▼aUniversity of Pennsylvania▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g85-03B.
■773 ▼tDissertation Abstract International
■790 ▼a0175
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933441▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
