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Alternating Selection for Dispersal and Multicellularity Favors Regulated Life Cycles- [electronic resource]
Alternating Selection for Dispersal and Multicellularity Favors Regulated Life Cycles- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100110
- ISBN
- 9798379613396
- DDC
- 574
- 저자명
- Barrere, Julien.
- 서명/저자
- Alternating Selection for Dispersal and Multicellularity Favors Regulated Life Cycles - [electronic resource]
- 발행사항
- [S.l.]: : Harvard University., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(117 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Advisor: Murray, Andrew;Desai, Michael.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약The evolution of complex multicellularity opened paths to increased morphological diversity and organizational novelty. This transition involved three processes: cells remained attached to one another to form groups, cells within these groups differentiated to perform different tasks, and the groups evolved new reproductive strategies. Recent experiments identified selective pressures and mutations that can drive the emergence of simple multicellularity and cell differentiation, but the evolution of life cycles, in particular, how simple multicellular forms reproduce has been understudied. The selective pressure and mechanisms that produced a regular alternation between single cells and multicellular collectives are still unclear. To probe the factors regulating simple multicellular life cycles, we examined a collection of wild isolates of the budding yeast Saccharomyces cerevisiae. We found that all these strains can exist as multicellular clusters, a phenotype controlled by the mating type locus and strongly influenced by the nutritional environment. Inspired by this variation, we engineered inducible dispersal in a multicellular laboratory strain and demonstrated that a regulated life cycle has an advantage over constitutively single-celled or constitutively multicellular life cycles when the environment alternates between favoring intercellular cooperation (a low sucrose concentration) and dispersal (a patchy environment generated by emulsion). Our results suggest that simple multicellularity in wild isolates could be under selection and is regulated by their genetic composition and the growth conditions they encounter and that alternating patterns of resource availability may have played a role in the evolution of life cycles.
- 일반주제명
- Biology.
- 일반주제명
- Cellular biology.
- 일반주제명
- Evolution & development.
- 키워드
- Clustering
- 키워드
- Multicellularity
- 키워드
- Life cycle
- 키워드
- Patchy resources
- 키워드
- Public goods
- 기타저자
- Harvard University Biology Molecular and Cellular
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008240612s2023 us |||||||||||||||c||eng d■001000016931732
■00520240214100110
■006m o d
■007cr#unu||||||||
■020 ▼a9798379613396
■035 ▼a(MiAaPQ)AAI30420742
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aBarrere, Julien.▼0(orcid)0000-0001-8096-8211
■24510▼aAlternating Selection for Dispersal and Multicellularity Favors Regulated Life Cycles▼h[electronic resource]
■260 ▼a[S.l.]:▼bHarvard University. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(117 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Murray, Andrew;Desai, Michael.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aThe evolution of complex multicellularity opened paths to increased morphological diversity and organizational novelty. This transition involved three processes: cells remained attached to one another to form groups, cells within these groups differentiated to perform different tasks, and the groups evolved new reproductive strategies. Recent experiments identified selective pressures and mutations that can drive the emergence of simple multicellularity and cell differentiation, but the evolution of life cycles, in particular, how simple multicellular forms reproduce has been understudied. The selective pressure and mechanisms that produced a regular alternation between single cells and multicellular collectives are still unclear. To probe the factors regulating simple multicellular life cycles, we examined a collection of wild isolates of the budding yeast Saccharomyces cerevisiae. We found that all these strains can exist as multicellular clusters, a phenotype controlled by the mating type locus and strongly influenced by the nutritional environment. Inspired by this variation, we engineered inducible dispersal in a multicellular laboratory strain and demonstrated that a regulated life cycle has an advantage over constitutively single-celled or constitutively multicellular life cycles when the environment alternates between favoring intercellular cooperation (a low sucrose concentration) and dispersal (a patchy environment generated by emulsion). Our results suggest that simple multicellularity in wild isolates could be under selection and is regulated by their genetic composition and the growth conditions they encounter and that alternating patterns of resource availability may have played a role in the evolution of life cycles.
■590 ▼aSchool code: 0084.
■650 4▼aBiology.
■650 4▼aCellular biology.
■650 4▼aEvolution & development.
■653 ▼aClustering
■653 ▼aMulticellularity
■653 ▼aLife cycle
■653 ▼aPatchy resources
■653 ▼aPublic goods
■653 ▼aSaccharomyces cerevisiae
■690 ▼a0306
■690 ▼a0412
■690 ▼a0379
■71020▼aHarvard University▼bBiology, Molecular and Cellular.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931732▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
