서브메뉴
검색
Quantitative Methods for Evidence Building in Clinical Pharmacology and Pharmaceutical Outcomes Research- [electronic resource]
Quantitative Methods for Evidence Building in Clinical Pharmacology and Pharmaceutical Outcomes Research- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214095842
- ISBN
- 9798379927059
- DDC
- 615
- 서명/저자
- Quantitative Methods for Evidence Building in Clinical Pharmacology and Pharmaceutical Outcomes Research - [electronic resource]
- 발행사항
- [S.l.]: : University of Minnesota., 2021
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2021
- 형태사항
- 1 online resource(183 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- 주기사항
- Advisor: Chapman, Scott A.;Kirstein, Mark.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2021.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약A variety of methods are employed to build evidence in pharmacology and pharmaceutical outcomes research. Descriptive and inferential statistics are used to describe the data and generalize findings to populations. Regression models, propensity score adjustment, and meta-analysis extend upon the quantitative approach to building evidence. Topic areas in this dissertation include demonstrating the application of these methods to a comparison of three-factor prothrombin complex concentrate versus four-factor prothrombin complex concentrate for emergent warfarin reversal via a propensity score adjusted retrospective cohort study and a systematic review and meta-analysis to address clinical problems and improve health outcomes. Also presented are the pharmacokinetics of intravenous N-acetylcysteine, Cysteine, and Glutathione and the effect of N-acetylcysteine as a reducing agent in Parkinson's disease and Gaucher disease. While quantitative methods help us explore, explain, and generalize from data, it is imperative to consider the clinical relevance of the findings. We found that four-factor prothrombin complex concentrate is preferred for emergent warfarin reversal. This is a finding is useful in real-world patient care. Also, increased N-acetylcysteine plasma concentrations and Glutathione redox ratio are related, which could be used to optimize dosing in future studies. These examples are described in detail as examples of applications of quantitative methods.
- 일반주제명
- Pharmaceutical sciences.
- 일반주제명
- Pharmacology.
- 일반주제명
- Biostatistics.
- 키워드
- Meta-analysis
- 키워드
- N-acetylcysteine
- 키워드
- Pharmacokinetics
- 키워드
- Warfarin
- 기타저자
- University of Minnesota Experimental & Clinical Pharmacology
- 기본자료저록
- Dissertations Abstracts International. 85-01B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008240612s2021 us |||||||||||||||c||eng d■001000016930951
■00520240214095842
■006m o d
■007cr#unu||||||||
■020 ▼a9798379927059
■035 ▼a(MiAaPQ)AAI28541556
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a615
■1001 ▼aMargraf, David James.
■24510▼aQuantitative Methods for Evidence Building in Clinical Pharmacology and Pharmaceutical Outcomes Research▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of Minnesota. ▼c2021
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2021
■300 ▼a1 online resource(183 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-01, Section: B.
■500 ▼aAdvisor: Chapman, Scott A.;Kirstein, Mark.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2021.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aA variety of methods are employed to build evidence in pharmacology and pharmaceutical outcomes research. Descriptive and inferential statistics are used to describe the data and generalize findings to populations. Regression models, propensity score adjustment, and meta-analysis extend upon the quantitative approach to building evidence. Topic areas in this dissertation include demonstrating the application of these methods to a comparison of three-factor prothrombin complex concentrate versus four-factor prothrombin complex concentrate for emergent warfarin reversal via a propensity score adjusted retrospective cohort study and a systematic review and meta-analysis to address clinical problems and improve health outcomes. Also presented are the pharmacokinetics of intravenous N-acetylcysteine, Cysteine, and Glutathione and the effect of N-acetylcysteine as a reducing agent in Parkinson's disease and Gaucher disease. While quantitative methods help us explore, explain, and generalize from data, it is imperative to consider the clinical relevance of the findings. We found that four-factor prothrombin complex concentrate is preferred for emergent warfarin reversal. This is a finding is useful in real-world patient care. Also, increased N-acetylcysteine plasma concentrations and Glutathione redox ratio are related, which could be used to optimize dosing in future studies. These examples are described in detail as examples of applications of quantitative methods.
■590 ▼aSchool code: 0130.
■650 4▼aPharmaceutical sciences.
■650 4▼aPharmacology.
■650 4▼aBiostatistics.
■653 ▼aMeta-analysis
■653 ▼aN-acetylcysteine
■653 ▼aPharmacokinetics
■653 ▼aProthrombin complex concentrate
■653 ▼aRegression models
■653 ▼aWarfarin
■690 ▼a0572
■690 ▼a0419
■690 ▼a0308
■71020▼aUniversity of Minnesota▼bExperimental & Clinical Pharmacology.
■7730 ▼tDissertations Abstracts International▼g85-01B.
■773 ▼tDissertation Abstract International
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2021
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16930951▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
