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Leveraging Computational Methods and Electronic Health Records-Linked Biobank Data in Oral and Craniofacial Health Research- [electronic resource]
Leveraging Computational Methods and Electronic Health Records-Linked Biobank Data in Oral and Craniofacial Health Research- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101912
- ISBN
- 9798380364690
- DDC
- 617.6
- 서명/저자
- Leveraging Computational Methods and Electronic Health Records-Linked Biobank Data in Oral and Craniofacial Health Research - [electronic resource]
- 발행사항
- [S.l.]: : University of California, Los Angeles., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(124 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-03, Section: A.
- 주기사항
- Advisor: Nishimura, Ichiro;Pasaniuc, Bogdan.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Bioinformatics and computational methods play an important role in advancing medical research with their ability to leverage large datasets, including data from electronic health records (EHR) linked biobanks. Precision medicine can benefit from leveraging a more comprehensive picture of a patient's genotypes and phenotypic presentation for targeted interventions and treatment planning. In this work, I discuss the applications of bioinformatics methods in the UCLA ATLAS biobank, in evaluating craniofacial traits and their risk factors: specifically, head and neck cancer and tobacco use disorder. First, I describe phenome-wide and lab-wide association analysis pipelines that leverage the breadth of the available information in the biobank, and the results of preliminary investigations of the phenome-wide and laboratory-wide associations of a genetic predisposition to tobacco use disorder. Next, I present the results of an evaluation of the predictive performance of a tobacco use polygenic score across different genetic ancestry groups and further discuss the differences in disease presentations in tobacco use-predisposed individuals with and without a history of the associated tobacco use behavior. Next, I employ these pipelines and statistical methods in the examination of the interplay of serum bilirubin, tobacco use, head and neck, and lung cancer. I present the results of this project, examining the effect of environmental and genetic factors on serum bilirubin and associations with head and neck cancer and lung cancer. Lastly, I propose a research project to examine the germline risk factors for oropharyngeal cancer and discuss the future directions of this work.
- 일반주제명
- Dentistry.
- 일반주제명
- Bioinformatics.
- 일반주제명
- Information science.
- 키워드
- Medical research
- 키워드
- Biobanks
- 키워드
- Genetic factors
- 키워드
- Tobacco use
- 기타저자
- University of California, Los Angeles Oral Biology 0615
- 기본자료저록
- Dissertations Abstracts International. 85-03A.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101912
■006m o d
■007cr#unu||||||||
■020 ▼a9798380364690
■035 ▼a(MiAaPQ)AAI30687032
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a617.6
■1001 ▼aVenkateswaran, Vidhya.
■24510▼aLeveraging Computational Methods and Electronic Health Records-Linked Biobank Data in Oral and Craniofacial Health Research▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of California, Los Angeles. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(124 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-03, Section: A.
■500 ▼aAdvisor: Nishimura, Ichiro;Pasaniuc, Bogdan.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aBioinformatics and computational methods play an important role in advancing medical research with their ability to leverage large datasets, including data from electronic health records (EHR) linked biobanks. Precision medicine can benefit from leveraging a more comprehensive picture of a patient's genotypes and phenotypic presentation for targeted interventions and treatment planning. In this work, I discuss the applications of bioinformatics methods in the UCLA ATLAS biobank, in evaluating craniofacial traits and their risk factors: specifically, head and neck cancer and tobacco use disorder. First, I describe phenome-wide and lab-wide association analysis pipelines that leverage the breadth of the available information in the biobank, and the results of preliminary investigations of the phenome-wide and laboratory-wide associations of a genetic predisposition to tobacco use disorder. Next, I present the results of an evaluation of the predictive performance of a tobacco use polygenic score across different genetic ancestry groups and further discuss the differences in disease presentations in tobacco use-predisposed individuals with and without a history of the associated tobacco use behavior. Next, I employ these pipelines and statistical methods in the examination of the interplay of serum bilirubin, tobacco use, head and neck, and lung cancer. I present the results of this project, examining the effect of environmental and genetic factors on serum bilirubin and associations with head and neck cancer and lung cancer. Lastly, I propose a research project to examine the germline risk factors for oropharyngeal cancer and discuss the future directions of this work.
■590 ▼aSchool code: 0031.
■650 4▼aDentistry.
■650 4▼aBioinformatics.
■650 4▼aInformation science.
■653 ▼aMedical research
■653 ▼aElectronic health records
■653 ▼aBiobanks
■653 ▼aCraniofacial traits
■653 ▼aGenetic factors
■653 ▼aTobacco use
■690 ▼a0567
■690 ▼a0715
■690 ▼a0723
■71020▼aUniversity of California, Los Angeles▼bOral Biology 0615.
■7730 ▼tDissertations Abstracts International▼g85-03A.
■773 ▼tDissertation Abstract International
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16935272▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
