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Reproductive, Metabolic, and Autonomic Networks Across the Female Lifespan- [electronic resource]
Reproductive, Metabolic, and Autonomic Networks Across the Female Lifespan- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214095856
- ISBN
- 9798380618694
- DDC
- 616
- 저자명
- Grant, Azure.
- 서명/저자
- Reproductive, Metabolic, and Autonomic Networks Across the Female Lifespan - [electronic resource]
- 발행사항
- [S.l.]: : University of California, Berkeley., 2021
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2021
- 형태사항
- 1 online resource(125 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-04, Section: A.
- 주기사항
- Advisor: Kriegsfeld, Lance J.;Wilbrecht, Linda.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2021.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Mammalian physiology is exquisitely tuned to anticipate and synchronize with environmental oscillations. These oscillations appear to occur in a networked fashion across systems and timescales, such that information about difficult-to-measure systems (e.g., reproductive) may be garnered from easy-to-measure systems (e.g., autonomic, and thermoregulatory). These network dynamics and their implications for health require deep exploration. The goals of this dissertation are to 1) investigate the relationship among reproductive, metabolic, and autonomic rhythms at the hourly to ovulatory timescales, and 2) investigate the conditions under which peripheral timeseries features may serve as proxies for hormonal status. This dissertation traverses discrete stages of reproductive life: adolescence, adulthood, and menopause; as well as the impacts of exogenous network perturbations at each stage of life. Chapter 1 reviews central mechanisms of coupled oscillations in the reproductive and thermoregulatory systems. Chapters 2 and 3 investigate the development of thermoregulatory rhythms across adolescence, their dependence on endogenous and exogenous reproductive hormones, their interaction with natural and artificial environments, and derive peripheral features to monitor reproductive development in the rat. Chapter 4 extends these findings to adult women and investigates shared rhythmicity among autonomic and thermoregulatory outputs and sex hormones for the purposes of LH surge prediction or identification of its absence in menopause. With an eye toward future developments in sex hormone replacement, Chapter 5 compares the effects of the most advanced forms of continuous hormone replacement therapy on biological rhythms in metabolic output. These studies inform our understanding of the structure of reproductive, metabolic, and autonomic networks across life, and reveal translational tools for reproductive health.
- 일반주제명
- Neurosciences.
- 일반주제명
- Endocrinology.
- 일반주제명
- Physiology.
- 일반주제명
- Womens studies.
- 키워드
- Diabetes
- 키워드
- Ovulatory cycle
- 키워드
- Puberty
- 키워드
- Female lifespan
- 기타저자
- University of California, Berkeley Neuroscience
- 기본자료저록
- Dissertations Abstracts International. 85-04A.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008240612s2021 us |||||||||||||||c||eng d■001000016931026
■00520240214095856
■006m o d
■007cr#unu||||||||
■020 ▼a9798380618694
■035 ▼a(MiAaPQ)AAI28719642
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aGrant, Azure.
■24510▼aReproductive, Metabolic, and Autonomic Networks Across the Female Lifespan▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of California, Berkeley. ▼c2021
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2021
■300 ▼a1 online resource(125 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-04, Section: A.
■500 ▼aAdvisor: Kriegsfeld, Lance J.;Wilbrecht, Linda.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2021.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aMammalian physiology is exquisitely tuned to anticipate and synchronize with environmental oscillations. These oscillations appear to occur in a networked fashion across systems and timescales, such that information about difficult-to-measure systems (e.g., reproductive) may be garnered from easy-to-measure systems (e.g., autonomic, and thermoregulatory). These network dynamics and their implications for health require deep exploration. The goals of this dissertation are to 1) investigate the relationship among reproductive, metabolic, and autonomic rhythms at the hourly to ovulatory timescales, and 2) investigate the conditions under which peripheral timeseries features may serve as proxies for hormonal status. This dissertation traverses discrete stages of reproductive life: adolescence, adulthood, and menopause; as well as the impacts of exogenous network perturbations at each stage of life. Chapter 1 reviews central mechanisms of coupled oscillations in the reproductive and thermoregulatory systems. Chapters 2 and 3 investigate the development of thermoregulatory rhythms across adolescence, their dependence on endogenous and exogenous reproductive hormones, their interaction with natural and artificial environments, and derive peripheral features to monitor reproductive development in the rat. Chapter 4 extends these findings to adult women and investigates shared rhythmicity among autonomic and thermoregulatory outputs and sex hormones for the purposes of LH surge prediction or identification of its absence in menopause. With an eye toward future developments in sex hormone replacement, Chapter 5 compares the effects of the most advanced forms of continuous hormone replacement therapy on biological rhythms in metabolic output. These studies inform our understanding of the structure of reproductive, metabolic, and autonomic networks across life, and reveal translational tools for reproductive health.
■590 ▼aSchool code: 0028.
■650 4▼aNeurosciences.
■650 4▼aEndocrinology.
■650 4▼aPhysiology.
■650 4▼aWomens studies.
■653 ▼aBiological rhythms
■653 ▼aDiabetes
■653 ▼aNetwork physiology
■653 ▼aOvulatory cycle
■653 ▼aPuberty
■653 ▼aReproductive health
■653 ▼aFemale lifespan
■690 ▼a0317
■690 ▼a0409
■690 ▼a0719
■690 ▼a0453
■71020▼aUniversity of California, Berkeley▼bNeuroscience.
■7730 ▼tDissertations Abstracts International▼g85-04A.
■773 ▼tDissertation Abstract International
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2021
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931026▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
