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The Genetics and Immunological Influences of Infectious Disease Outcome- [electronic resource]
The Genetics and Immunological Influences of Infectious Disease Outcome- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101532
- ISBN
- 9798380133432
- DDC
- 616.079
- 저자명
- Tibbs, Taylor N.
- 서명/저자
- The Genetics and Immunological Influences of Infectious Disease Outcome - [electronic resource]
- 발행사항
- [S.l.]: : The University of North Carolina at Chapel Hill., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(146 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
- 주기사항
- Advisor: Whitmire, Jason K.
- 학위논문주기
- Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Viral hemorrhagic disease (VHD) is a major public health concern with mortality rates ranging from 10-90%. While multiple virus families can elicit VHD, the mechanisms dictating the large ranges in fatality are not well understood. Both genetics and immune responses play pivotal roles in disease outcome. There are limited animal models of VHD. Many of the available models are expensive, require high biosafety containment, and/or extensively modified hosts or viruses. Herein, I describe a mouse model of VHD that accurately recapitulates human VHD symptoms without extensive genetic modification. This model is also safe and cost-effective. Furthermore, I have identified key immune cell populations and genetics that influence VHD susceptibility and pathogenesis. The results I have obtained here pave the way for both an improved animal model for studying VHD and insights into possible genetic candidates for therapeutic intervention.
- 일반주제명
- Immunology.
- 일반주제명
- Microbiology.
- 일반주제명
- Genetics.
- 일반주제명
- Public health.
- 키워드
- Infection
- 키워드
- Mouse model
- 키워드
- Virus
- 키워드
- Immune responses
- 기타저자
- The University of North Carolina at Chapel Hill Microbiology and Immunology
- 기본자료저록
- Dissertations Abstracts International. 85-02B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798380133432
■035 ▼a(MiAaPQ)AAI30571770
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616.079
■1001 ▼aTibbs, Taylor N.
■24510▼aThe Genetics and Immunological Influences of Infectious Disease Outcome▼h[electronic resource]
■260 ▼a[S.l.]:▼bThe University of North Carolina at Chapel Hill. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(146 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-02, Section: B.
■500 ▼aAdvisor: Whitmire, Jason K.
■5021 ▼aThesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aViral hemorrhagic disease (VHD) is a major public health concern with mortality rates ranging from 10-90%. While multiple virus families can elicit VHD, the mechanisms dictating the large ranges in fatality are not well understood. Both genetics and immune responses play pivotal roles in disease outcome. There are limited animal models of VHD. Many of the available models are expensive, require high biosafety containment, and/or extensively modified hosts or viruses. Herein, I describe a mouse model of VHD that accurately recapitulates human VHD symptoms without extensive genetic modification. This model is also safe and cost-effective. Furthermore, I have identified key immune cell populations and genetics that influence VHD susceptibility and pathogenesis. The results I have obtained here pave the way for both an improved animal model for studying VHD and insights into possible genetic candidates for therapeutic intervention.
■590 ▼aSchool code: 0153.
■650 4▼aImmunology.
■650 4▼aMicrobiology.
■650 4▼aGenetics.
■650 4▼aPublic health.
■653 ▼aHemorrhagic disease
■653 ▼aInfection
■653 ▼aMouse model
■653 ▼aVirus
■653 ▼aImmune responses
■690 ▼a0982
■690 ▼a0410
■690 ▼a0369
■690 ▼a0573
■71020▼aThe University of North Carolina at Chapel Hill▼bMicrobiology and Immunology.
■7730 ▼tDissertations Abstracts International▼g85-02B.
■773 ▼tDissertation Abstract International
■790 ▼a0153
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16934129▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
