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Development and Validation of Models to Predict Hypertension in Latin Americans- [electronic resource]
Development and Validation of Models to Predict Hypertension in Latin Americans - [electro...
Development and Validation of Models to Predict Hypertension in Latin Americans- [electronic resource]

Detailed Information

자료유형  
 학위논문파일 국외
최종처리일시  
20240214101240
ISBN  
9798379719654
DDC  
614.4
저자명  
Bajwa, Pravleen K.
서명/저자  
Development and Validation of Models to Predict Hypertension in Latin Americans - [electronic resource]
발행사항  
[S.l.]: : The University of Wisconsin - Madison., 2023
발행사항  
Ann Arbor : : ProQuest Dissertations & Theses,, 2023
형태사항  
1 online resource(138 p.)
주기사항  
Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
주기사항  
Advisor: Bautista, Leonelo.
학위논문주기  
Thesis (Ph.D.)--The University of Wisconsin - Madison, 2023.
사용제한주기  
This item must not be sold to any third party vendors.
초록/해제  
요약Blood pressure (BP) prediction models can be useful for identifying individuals at high risk for developing hypertension. However, using models developed in a population with different underlying characteristics can under- or over-estimate the risk. Currently, no BP prediction models have been developed for Latin Americans. Additionally, all current models predicting high BP dichotomize BP instead of predicting continuous systolic (SBP) or diastolic (DBP) blood pressure. This can lead to loss of information and statistical power and relies on predefined BP cut-points to define hypertension. In this dissertation, we start with a systematic literature review of studies that developed or externally validated models predicting hypertension risk or another BP-related outcome. Then, we develop a model to predict the risk of incident hypertension in a Latin American population (Colombia). Finally, we develop a model to predict future SBP and DBP in the same population. We found that most existing models showed a high risk of bias due to limitations in the analyses. Our binary model had good discrimination but over-predicted the risk of hypertension in some deciles of predicted risk. Our continuous model showed better agreement over deciles of predicted BP. However, it tended to under-predict the BP in the higher and lower tails of the BP distribution. Overall, we created two high BP prediction models for Colombian adults and recommend the use of the continuous model. We also share user-friendly nomograms for both models to facilitate convenient predictions.
일반주제명  
Epidemiology.
일반주제명  
Public health.
일반주제명  
Biostatistics.
키워드  
Blood pressure
키워드  
Calibration
키워드  
Discrimination
키워드  
Hypertension
키워드  
Model validation
키워드  
Prediction modeling
기타저자  
The University of Wisconsin - Madison Population Health
기본자료저록  
Dissertations Abstracts International. 84-12B.
기본자료저록  
Dissertation Abstract International
전자적 위치 및 접속  
로그인 후 원문을 볼 수 있습니다.

MARC

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■00520240214101240
■006m          o    d                
■007cr#unu||||||||
■020    ▼a9798379719654
■035    ▼a(MiAaPQ)AAI30528349
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a614.4
■1001  ▼aBajwa,  Pravleen  K.
■24510▼aDevelopment  and  Validation  of  Models  to  Predict  Hypertension  in  Latin  Americans▼h[electronic  resource]
■260    ▼a[S.l.]:▼bThe  University  of  Wisconsin  -  Madison.  ▼c2023
■260  1▼aAnn  Arbor  :▼bProQuest  Dissertations  &  Theses,  ▼c2023
■300    ▼a1  online  resource(138  p.)
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  84-12,  Section:  B.
■500    ▼aAdvisor:  Bautista,  Leonelo.
■5021  ▼aThesis  (Ph.D.)--The  University  of  Wisconsin  -  Madison,  2023.
■506    ▼aThis  item  must  not  be  sold  to  any  third  party  vendors.
■520    ▼aBlood  pressure  (BP)  prediction  models  can  be  useful  for  identifying  individuals  at  high  risk  for  developing  hypertension.  However,  using  models  developed  in  a  population  with  different  underlying  characteristics  can  under-  or  over-estimate  the  risk.  Currently,  no  BP  prediction  models  have  been  developed  for  Latin  Americans.  Additionally,  all  current  models  predicting  high  BP  dichotomize  BP  instead  of  predicting  continuous  systolic  (SBP)  or  diastolic  (DBP)  blood  pressure.  This  can  lead  to  loss  of  information  and  statistical  power  and  relies  on  predefined  BP  cut-points  to  define  hypertension.  In  this  dissertation,  we  start  with  a  systematic  literature  review  of  studies  that  developed  or  externally  validated  models  predicting  hypertension  risk  or  another  BP-related  outcome.  Then,  we  develop  a  model  to  predict  the  risk  of  incident  hypertension  in  a  Latin  American  population  (Colombia).  Finally,  we  develop  a  model  to  predict  future  SBP  and  DBP  in  the  same  population.  We  found  that  most  existing  models  showed  a  high  risk  of  bias  due  to  limitations  in  the  analyses.  Our  binary  model  had  good  discrimination  but  over-predicted  the  risk  of  hypertension  in  some  deciles  of  predicted  risk.  Our  continuous  model  showed  better  agreement  over  deciles  of  predicted  BP.  However,  it  tended  to  under-predict  the  BP  in  the  higher  and  lower  tails  of  the  BP  distribution.  Overall,  we  created  two  high  BP  prediction  models  for  Colombian  adults  and  recommend  the  use  of  the  continuous  model.  We  also  share  user-friendly  nomograms  for  both  models  to  facilitate  convenient  predictions.
■590    ▼aSchool  code:  0262.
■650  4▼aEpidemiology.
■650  4▼aPublic  health.
■650  4▼aBiostatistics.
■653    ▼aBlood  pressure
■653    ▼aCalibration
■653    ▼aDiscrimination
■653    ▼aHypertension
■653    ▼aModel  validation
■653    ▼aPrediction  modeling
■690    ▼a0766
■690    ▼a0573
■690    ▼a0308
■71020▼aThe  University  of  Wisconsin  -  Madison▼bPopulation  Health.
■7730  ▼tDissertations  Abstracts  International▼g84-12B.
■773    ▼tDissertation  Abstract  International
■790    ▼a0262
■791    ▼aPh.D.
■792    ▼a2023
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933384▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.
■980    ▼a202402▼f2024

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