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Form and Function in the Heart and Placenta: Quantitative Vascular MRI- [electronic resource]
Form and Function in the Heart and Placenta: Quantitative Vascular MRI- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101242
- ISBN
- 9798379719647
- DDC
- 616
- 서명/저자
- Form and Function in the Heart and Placenta: Quantitative Vascular MRI - [electronic resource]
- 발행사항
- [S.l.]: : The University of Wisconsin - Madison., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(123 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Advisor: Wieben, Oliver.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Magnetic Resonance Imaging (MRI) is a powerful diagnostic modality, able to capture both functional and anatomical data noninvasively. The aim of this dissertation was to develop and assess novel MRI methodology in acquisition, reconstruction, and post-processing to advance in-vivo assessment of disease in two regions of the body: 1) the placenta and 2) the heart.1) The placenta plays a critical role in the development and long-term health of both fetus and mother; the ability to adequately quantify placental function in vivo, especially in early pregnancy could be a powerful tool for clinical decision making and therapeutic monitoring yet is currently not available. Ultrasound is commonly used in prenatal care, but its value to assess placental function is limited by a narrow field of view and poor contrast between uterus and placenta. Here, the value of dynamic contrast enhanced MRI for identifying underlying placental structures, quantifying their volumes and functional parameters associated with contrast bolus passage, and assessing their changes with pathology is demonstrated in a Rhesus Macaque model of zika virus, potentially laying the foundation for feasibility studies in humans. A promising alternative to flow associated functional analysis without the need for a contrast agent is velocity selective arterial spin labelling (VS-ASL) MRI; we present a large human study of normal and high body mass index (BMI) patients and report perfusion heterogeneity and trends that offer insight into placental development.
- 일반주제명
- Medical imaging.
- 일반주제명
- Medicine.
- 일반주제명
- Physics.
- 키워드
- Cardiovascular
- 키워드
- Exercise
- 키워드
- Perfusion
- 키워드
- Body mass index
- 기타저자
- The University of Wisconsin - Madison Medical Physics
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101242
■006m o d
■007cr#unu||||||||
■020 ▼a9798379719647
■035 ▼a(MiAaPQ)AAI30528839
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aSeiter, Daniel P. .
■24510▼aForm and Function in the Heart and Placenta: Quantitative Vascular MRI▼h[electronic resource]
■260 ▼a[S.l.]:▼bThe University of Wisconsin - Madison. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(123 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Wieben, Oliver.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aMagnetic Resonance Imaging (MRI) is a powerful diagnostic modality, able to capture both functional and anatomical data noninvasively. The aim of this dissertation was to develop and assess novel MRI methodology in acquisition, reconstruction, and post-processing to advance in-vivo assessment of disease in two regions of the body: 1) the placenta and 2) the heart.1) The placenta plays a critical role in the development and long-term health of both fetus and mother; the ability to adequately quantify placental function in vivo, especially in early pregnancy could be a powerful tool for clinical decision making and therapeutic monitoring yet is currently not available. Ultrasound is commonly used in prenatal care, but its value to assess placental function is limited by a narrow field of view and poor contrast between uterus and placenta. Here, the value of dynamic contrast enhanced MRI for identifying underlying placental structures, quantifying their volumes and functional parameters associated with contrast bolus passage, and assessing their changes with pathology is demonstrated in a Rhesus Macaque model of zika virus, potentially laying the foundation for feasibility studies in humans. A promising alternative to flow associated functional analysis without the need for a contrast agent is velocity selective arterial spin labelling (VS-ASL) MRI; we present a large human study of normal and high body mass index (BMI) patients and report perfusion heterogeneity and trends that offer insight into placental development.
■590 ▼aSchool code: 0262.
■650 4▼aMedical imaging.
■650 4▼aMedicine.
■650 4▼aPhysics.
■653 ▼aCardiovascular
■653 ▼aExercise
■653 ▼aMagnetic resonance imaging
■653 ▼aPerfusion
■653 ▼aPlacental development
■653 ▼aBody mass index
■690 ▼a0574
■690 ▼a0564
■690 ▼a0605
■71020▼aThe University of Wisconsin - Madison▼bMedical Physics.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933404▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
