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The Role of Innate Cell Differentiation in Promoting yki3S/a Intestinal Tumor Cell Invasiveness and Defining the Systemic Cachexia-Like Wasting Phenotypes- [electronic resource]
The Role of Innate Cell Differentiation in Promoting yki3S/a Intestinal Tumor Cell Invasiveness and Defining the Systemic Cachexia-Like Wasting Phenotypes- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101158
- ISBN
- 9798379911362
- DDC
- 574
- 서명/저자
- The Role of Innate Cell Differentiation in Promoting yki3S/a Intestinal Tumor Cell Invasiveness and Defining the Systemic Cachexia-Like Wasting Phenotypes - [electronic resource]
- 발행사항
- [S.l.]: : University of Washington., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(61 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- 주기사항
- Advisor: Kwon, Young.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Many tumors recapitulate the developmental and differentiation program of their tissue of origin, a basis for tumor cell heterogeneity. Although stem-cell-like tumor cells are well-studied, the roles of tumor cells undergoing differentiation in inducing the phenotypes associated with advanced cancers remains to be elucidated. Here, we employ Drosophila genetics to demonstrate that the native differentiation program of intestinal stem cells plays a key role in determining an intestinal tumor's capacity to invade and induce various non-tumor-autonomous phenotypes. The differentiation program that generates absorptive cells called enterocytes is aberrantly recapitulated in the intestinal tumors generated through activation of the Yap1 ortholog Yorkie. Elimination of tumor cells in the enterocyte lineage allows stem cell-like tumor cells to grow but suppresses invasiveness and reshapes various phenotypes associated with cachexia-like wasting by altering the expression of tumor-derived factors. Meanwhile, enriching the intermediately differentiated tumor cells in the enterocyte lineage promotes a more robust and quicker tumor growth that lacks cell invasive properties but enhances tumor-derived factors expression, resulting in a more advanced manifestation of cachexia-like wasting syndrome in the host. This study provides insight into how a native differentiation program determines a tumor's capacity to induce the phenotypes associated with advanced cancers and suggests that manipulating the differentiation programs co-opted in tumors might be a way to treat some complications of cancer, including cachexia.
- 일반주제명
- Biochemistry.
- 일반주제명
- Cellular biology.
- 일반주제명
- Oncology.
- 기타저자
- University of Washington Biochemistry
- 기본자료저록
- Dissertations Abstracts International. 85-01B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101158
■006m o d
■007cr#unu||||||||
■020 ▼a9798379911362
■035 ▼a(MiAaPQ)AAI30524236
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aPranoto, Inez Keiko Arlyne.
■24510▼aThe Role of Innate Cell Differentiation in Promoting yki3S/a Intestinal Tumor Cell Invasiveness and Defining the Systemic Cachexia-Like Wasting Phenotypes▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of Washington. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(61 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-01, Section: B.
■500 ▼aAdvisor: Kwon, Young.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aMany tumors recapitulate the developmental and differentiation program of their tissue of origin, a basis for tumor cell heterogeneity. Although stem-cell-like tumor cells are well-studied, the roles of tumor cells undergoing differentiation in inducing the phenotypes associated with advanced cancers remains to be elucidated. Here, we employ Drosophila genetics to demonstrate that the native differentiation program of intestinal stem cells plays a key role in determining an intestinal tumor's capacity to invade and induce various non-tumor-autonomous phenotypes. The differentiation program that generates absorptive cells called enterocytes is aberrantly recapitulated in the intestinal tumors generated through activation of the Yap1 ortholog Yorkie. Elimination of tumor cells in the enterocyte lineage allows stem cell-like tumor cells to grow but suppresses invasiveness and reshapes various phenotypes associated with cachexia-like wasting by altering the expression of tumor-derived factors. Meanwhile, enriching the intermediately differentiated tumor cells in the enterocyte lineage promotes a more robust and quicker tumor growth that lacks cell invasive properties but enhances tumor-derived factors expression, resulting in a more advanced manifestation of cachexia-like wasting syndrome in the host. This study provides insight into how a native differentiation program determines a tumor's capacity to induce the phenotypes associated with advanced cancers and suggests that manipulating the differentiation programs co-opted in tumors might be a way to treat some complications of cancer, including cachexia.
■590 ▼aSchool code: 0250.
■650 4▼aBiochemistry.
■650 4▼aCellular biology.
■650 4▼aOncology.
■653 ▼aCell differentiation
■653 ▼aCachexia-like wasting syndrome
■653 ▼aTumor cell heterogeneity
■653 ▼aTumor cell invasiveness
■690 ▼a0487
■690 ▼a0379
■690 ▼a0992
■71020▼aUniversity of Washington▼bBiochemistry.
■7730 ▼tDissertations Abstracts International▼g85-01B.
■773 ▼tDissertation Abstract International
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933058▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
