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Functional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging- [electronic resource]
Functional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101705
- ISBN
- 9798380850322
- DDC
- 616
- 저자명
- Angeli, Peter A.
- 서명/저자
- Functional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging - [electronic resource]
- 발행사항
- [S.l.]: : Harvard University., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(245 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
- 주기사항
- Advisor: Buckner, Randy L.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약This dissertation describes my efforts towards a precise network-informed functional characterization of the human hippocampal long axis, made possible by advances in within-individual precision human neuroimaging. In the Introduction, I describe foundational work that has proposed the differential involvement of hippocampal regions in diverse cognitive functions including episodic memory, spatial reasoning, and assessing novelty. While a definitive account of hippocampal function will remain elusive, I will argue it is both conceptually important and experimentally useful to study the functional roles of the hippocampus in the context of associated networks precisely estimated in cerebral cortex.The first two chapters highlight the neuroimaging techniques necessary for precisely estimating hippocampal network organization and function. These chapters focus on the cerebellum, in part because that was my own introduction to these methods, but also because these methods' success given the cerebellum's polysynaptic connectivity to cortex and fine structural details strengthens the case for their use in the hippocampus. Chapter 1 uses functional neuroimaging techniques to explore the organization of the human cerebellum based on network functional connectivity. Chapter 2 applies within-individual neuroimaging of the cerebellum to simple motor tasks. In both cases, exploring a small set of densely sampled individuals allowed all analyses to respect each participant's idiosyncratic anatomy, improving resolution and allowing for the characterization of functional and organizational details that would have been missed using approaches which spatially average data across participants.Chapter 3 applies these techniques to the hippocampal long axis across two independent sets of densely sampled individuals. We first demonstrate differential functional connectivity from the anterior and posterior hippocampus to distinct cerebral networks DN-A and SAL / PMN, respectively. Task data then reveals a double-dissociation: the anterior hippocampus is preferentially involved in the construction of mental scenes, while the posterior hippocampus displays transient activation in response to salient stimuli. These parallel dissociations in functional connectivity and cognitive function position the anterior and posterior hippocampus as separable components of broader brain networks and refines our understanding of hippocampal contributions to human cognition.
- 일반주제명
- Neurosciences.
- 일반주제명
- Psychology.
- 일반주제명
- Medical imaging.
- 키워드
- Hippocampus
- 키워드
- Memory
- 키워드
- Neuroimaging
- 키워드
- Brain networks
- 기타저자
- Harvard University Medical Sciences
- 기본자료저록
- Dissertations Abstracts International. 85-05B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101705
■006m o d
■007cr#unu||||||||
■020 ▼a9798380850322
■035 ▼a(MiAaPQ)AAI30636117
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aAngeli, Peter A.▼0(orcid)0000-0002-0208-5808
■24510▼aFunctional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging▼h[electronic resource]
■260 ▼a[S.l.]:▼bHarvard University. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(245 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-05, Section: B.
■500 ▼aAdvisor: Buckner, Randy L.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aThis dissertation describes my efforts towards a precise network-informed functional characterization of the human hippocampal long axis, made possible by advances in within-individual precision human neuroimaging. In the Introduction, I describe foundational work that has proposed the differential involvement of hippocampal regions in diverse cognitive functions including episodic memory, spatial reasoning, and assessing novelty. While a definitive account of hippocampal function will remain elusive, I will argue it is both conceptually important and experimentally useful to study the functional roles of the hippocampus in the context of associated networks precisely estimated in cerebral cortex.The first two chapters highlight the neuroimaging techniques necessary for precisely estimating hippocampal network organization and function. These chapters focus on the cerebellum, in part because that was my own introduction to these methods, but also because these methods' success given the cerebellum's polysynaptic connectivity to cortex and fine structural details strengthens the case for their use in the hippocampus. Chapter 1 uses functional neuroimaging techniques to explore the organization of the human cerebellum based on network functional connectivity. Chapter 2 applies within-individual neuroimaging of the cerebellum to simple motor tasks. In both cases, exploring a small set of densely sampled individuals allowed all analyses to respect each participant's idiosyncratic anatomy, improving resolution and allowing for the characterization of functional and organizational details that would have been missed using approaches which spatially average data across participants.Chapter 3 applies these techniques to the hippocampal long axis across two independent sets of densely sampled individuals. We first demonstrate differential functional connectivity from the anterior and posterior hippocampus to distinct cerebral networks DN-A and SAL / PMN, respectively. Task data then reveals a double-dissociation: the anterior hippocampus is preferentially involved in the construction of mental scenes, while the posterior hippocampus displays transient activation in response to salient stimuli. These parallel dissociations in functional connectivity and cognitive function position the anterior and posterior hippocampus as separable components of broader brain networks and refines our understanding of hippocampal contributions to human cognition.
■590 ▼aSchool code: 0084.
■650 4▼aNeurosciences.
■650 4▼aPsychology.
■650 4▼aMedical imaging.
■653 ▼aHippocampus
■653 ▼aMemory
■653 ▼aNeuroimaging
■653 ▼aBrain networks
■690 ▼a0317
■690 ▼a0621
■690 ▼a0574
■71020▼aHarvard University▼bMedical Sciences.
■7730 ▼tDissertations Abstracts International▼g85-05B.
■773 ▼tDissertation Abstract International
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16934867▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
