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Reading, Writing, and Perturbing Human Neural Cell Biology- [electronic resource]
![Reading, Writing, and Perturbing Human Neural Cell Biology - [electronic resource]](/Users/Baul/Images/book.png)
Reading, Writing, and Perturbing Human Neural Cell Biology- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100124
- ISBN
- 9798379750848
- DDC
- 574
- 서명/저자
- Reading, Writing, and Perturbing Human Neural Cell Biology - [electronic resource]
- 발행사항
- [S.l.]: : University of Pennsylvania., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(192 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Advisor: Shalem, Ophir;Song, Hongjun.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Unraveling the complexity of human brain function demands integrated profiling, generation, and creative disruption of cell type-specific states to decode genotype-phenotype relationships. Here, I present a thesis tackling each of these areas. Profiling or "reading" of human brain tissue at the single cell level with technical innovations in transcriptomics provides deep molecular and cellular reference maps describing the landscape of human neural cell types. Generation or "writing" of synthetic human neural tissue using emerging human induced pluripotent stem cell differentiation technologies provides tractable cellular models to study human-specific neural cell biology. Disruption or "perturbing" of human neural tissue with pooled genome editing CRISPR screening systems enables scalable discovery of novel genotype-phenotype relationships. Continued work in these areas will enhance our understanding of how human neural phenotypes shift from healthy to diseased states and inform the development of new therapeutics and diagnostics to drive human neural phenotypes from diseased to healthy states.
- 일반주제명
- Cellular biology.
- 일반주제명
- Molecular biology.
- 일반주제명
- Neurosciences.
- 키워드
- Neural organoids
- 기타저자
- University of Pennsylvania Cell and Molecular Biology
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214100124
■006m o d
■007cr#unu||||||||
■020 ▼a9798379750848
■035 ▼a(MiAaPQ)AAI30424826
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aPather, Sarshan Rubintheran.
■24510▼aReading, Writing, and Perturbing Human Neural Cell Biology▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of Pennsylvania. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(192 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Shalem, Ophir;Song, Hongjun.
■5021 ▼aThesis (Ph.D.)--University of Pennsylvania, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aUnraveling the complexity of human brain function demands integrated profiling, generation, and creative disruption of cell type-specific states to decode genotype-phenotype relationships. Here, I present a thesis tackling each of these areas. Profiling or "reading" of human brain tissue at the single cell level with technical innovations in transcriptomics provides deep molecular and cellular reference maps describing the landscape of human neural cell types. Generation or "writing" of synthetic human neural tissue using emerging human induced pluripotent stem cell differentiation technologies provides tractable cellular models to study human-specific neural cell biology. Disruption or "perturbing" of human neural tissue with pooled genome editing CRISPR screening systems enables scalable discovery of novel genotype-phenotype relationships. Continued work in these areas will enhance our understanding of how human neural phenotypes shift from healthy to diseased states and inform the development of new therapeutics and diagnostics to drive human neural phenotypes from diseased to healthy states.
■590 ▼aSchool code: 0175.
■650 4▼aCellular biology.
■650 4▼aMolecular biology.
■650 4▼aNeurosciences.
■653 ▼aIn situ sequencing
■653 ▼aInduced pluripotent stem cells
■653 ▼aNeural organoids
■653 ▼aOptical screening
■653 ▼aSingle cell biology
■690 ▼a0379
■690 ▼a0307
■690 ▼a0317
■71020▼aUniversity of Pennsylvania▼bCell and Molecular Biology.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0175
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931826▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
