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Ploidy, Genetics, and Metabolomics of Achillea, a Venerable and Variable Medicinal Plant- [electronic resource]
Ploidy, Genetics, and Metabolomics of Achillea, a Venerable and Variable Medicinal Plant- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214095927
- ISBN
- 9798380598958
- DDC
- 543
- 서명/저자
- Ploidy, Genetics, and Metabolomics of Achillea, a Venerable and Variable Medicinal Plant - [electronic resource]
- 발행사항
- [S.l.]: : University of Minnesota., 2022
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2022
- 형태사항
- 1 online resource(207 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
- 주기사항
- Advisor: Hegeman, Adrian D.
- 학위논문주기
- Thesis (Ph.D.)--University of Minnesota, 2022.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Humans have turned to plants for medicine since ancient times. In recent centuries technology has allowed isolation of pure compounds which largely replaced herbal medicines in the USA around the beginning of the 20th century. However, even in today's world of modern medicine, some herbal medicines can offer support for health in ways that pharmaceutical drugs cannot. With the advent of high resolution analytical instruments it is now possible to reconsider herbal medicines in all of their chemical complexity. Using the ancient medicinal plant Achillea millefolium as a case study, I use high resolution accurate mass-mass spectrometry to chemically profile 115 publicly available accessions of Achillea spp. cultivated in a common garden.In Chapter 1 I describe a brief history of medicine and technology to understand how we arrived at the current reductionist single-active-constituent mindset, and why it is important to broaden our mental model. In Chapter 2 I use flow cytometry and karyology to describe the ploidy of each of the 115 Achillea accessions. I also use DArTseq, a SNP analysis technique, to describe the population structure among these accessions. Finally, in Chapter 3 I use high performance liquid chromatography tandem to a high resolution mass spectrometer to chemically profile the 115 accessions. Altogether, this study helps to better understand the role that ploidy and genotype play in the chemotype of Achillea spp. The high resolution chemical profiling also helps to re-envision plants with a higher level of chemical complexity. Additionally, it serves as a potential model for improving approaches to quality control in the herbal industry.
- 일반주제명
- Analytical chemistry.
- 일반주제명
- Botany.
- 일반주제명
- Plant sciences.
- 일반주제명
- Genetics.
- 키워드
- Achillea
- 키워드
- Metabolomics
- 키워드
- Ploidy
- 기타저자
- University of Minnesota Plant and Microbial Biology
- 기본자료저록
- Dissertations Abstracts International. 85-04B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798380598958
■035 ▼a(MiAaPQ)AAI29393367
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a543
■1001 ▼aSammons, Katherine A.
■24510▼aPloidy, Genetics, and Metabolomics of Achillea, a Venerable and Variable Medicinal Plant▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of Minnesota. ▼c2022
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2022
■300 ▼a1 online resource(207 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-04, Section: B.
■500 ▼aAdvisor: Hegeman, Adrian D.
■5021 ▼aThesis (Ph.D.)--University of Minnesota, 2022.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aHumans have turned to plants for medicine since ancient times. In recent centuries technology has allowed isolation of pure compounds which largely replaced herbal medicines in the USA around the beginning of the 20th century. However, even in today's world of modern medicine, some herbal medicines can offer support for health in ways that pharmaceutical drugs cannot. With the advent of high resolution analytical instruments it is now possible to reconsider herbal medicines in all of their chemical complexity. Using the ancient medicinal plant Achillea millefolium as a case study, I use high resolution accurate mass-mass spectrometry to chemically profile 115 publicly available accessions of Achillea spp. cultivated in a common garden.In Chapter 1 I describe a brief history of medicine and technology to understand how we arrived at the current reductionist single-active-constituent mindset, and why it is important to broaden our mental model. In Chapter 2 I use flow cytometry and karyology to describe the ploidy of each of the 115 Achillea accessions. I also use DArTseq, a SNP analysis technique, to describe the population structure among these accessions. Finally, in Chapter 3 I use high performance liquid chromatography tandem to a high resolution mass spectrometer to chemically profile the 115 accessions. Altogether, this study helps to better understand the role that ploidy and genotype play in the chemotype of Achillea spp. The high resolution chemical profiling also helps to re-envision plants with a higher level of chemical complexity. Additionally, it serves as a potential model for improving approaches to quality control in the herbal industry.
■590 ▼aSchool code: 0130.
■650 4▼aAnalytical chemistry.
■650 4▼aBotany.
■650 4▼aPlant sciences.
■650 4▼aGenetics.
■653 ▼aAchillea
■653 ▼aMass spectrometry
■653 ▼aMetabolomics
■653 ▼aPloidy
■653 ▼aLiquid chromatography
■690 ▼a0486
■690 ▼a0309
■690 ▼a0479
■690 ▼a0369
■71020▼aUniversity of Minnesota▼bPlant and Microbial Biology.
■7730 ▼tDissertations Abstracts International▼g85-04B.
■773 ▼tDissertation Abstract International
■790 ▼a0130
■791 ▼aPh.D.
■792 ▼a2022
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931154▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
