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Developing Novel Disease Screening Tools by Measuring Critical Biochemical and Physiological Signals- [electronic resource]
Developing Novel Disease Screening Tools by Measuring Critical Biochemical and Physiological Signals- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101232
- ISBN
- 9798379912222
- DDC
- 621.3
- 저자명
- Sharma, Manuja.
- 서명/저자
- Developing Novel Disease Screening Tools by Measuring Critical Biochemical and Physiological Signals - [electronic resource]
- 발행사항
- [S.l.]: : University of Washington., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(125 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- 주기사항
- Advisor: Patel, Shwetak N.;Seibel, Eric J.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Health screening tools that are reliable and accurate have successfully reduced the burden on expensive diagnostic testing along with providing the opportunity of quick, lower cost treatments to a larger community. Designing these tools require interdisciplinary efforts, and in this thesis, author explores development of screening tools for two different bacterial diseases in collaboration with clinicians, researchers, and engineers. Oral Caries and Pulmonary Tuberculosis (TB), bacterial diseases affecting millions across the world, face unique challenges in early disease screening. In the case of oral caries, quantitative screening tools are very limited while in TB screening, the lack of low-cost screening device leaves millions of TB cases undetected. This thesis presents novel sensing techniques based on measuring critical biomarkers, identified with the help of clinicians, that can provide rapid, accurate, quantitative, and non-invasive feedback. Particularly, to reduce gaps in dentistry, thesis focuses on developing tools to measure acidity of oral biofilm. This acidity plays a vital role in the formation of oral caries, yet tools to measure it clinically are absent. O-pH, an optical pH monitoring device is presented that measures the acidity of dental plaque using non-invasive, opto-electronic sensors and provides quantitative feedback of oral health to dentists. The results from in vitro validation and in vivo study with 30 subjects indicate that the device is reliable and accurate. The spot based device is extended to mapping pH using images and a proof-of-concept device built with multimodal-scanning fiber (mm-SFE) is presented. This technology can enable trend based oral health monitoring using pH. In the next part of the thesis, the similar design process is applied to develop a screening tool for TB that focuses on cough as a biomarker. The production of cough in TB patients are primarily in response to changes in lung tissues, which the thesis hypothesizes can result in differences in cough sounds compared to other respiratory health issues. To validate, the author presents, TBscreen, a ResNet-18 model, based on scalogram images of passive coughs. TBscreen was trained and validated using a controlled dataset of passive cough sounds of subjects with TB and other respiratory health ailments. The analysis indicates the sounds from coughing contain disease biomarkers that increases with bacterial load and has the potential to enable large scale screening. Further, results indicate that passive or natural coughs differ from forced coughs, coughs produced on an external prompt, making it difficult to use forced coughs as a proxy for passive coughs. Through development of these two new sensing tools into human subject studies, the author argues that significant contributions have been made to the engineering and medical communities at large.
- 일반주제명
- Electrical engineering.
- 일반주제명
- Computer engineering.
- 일반주제명
- Biomedical engineering.
- 키워드
- Oral biofilm
- 키워드
- Screening tool
- 기타저자
- University of Washington Electrical and Computer Engineering
- 기본자료저록
- Dissertations Abstracts International. 85-01B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214101232
■006m o d
■007cr#unu||||||||
■020 ▼a9798379912222
■035 ▼a(MiAaPQ)AAI30527531
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a621.3
■1001 ▼aSharma, Manuja.
■24510▼aDeveloping Novel Disease Screening Tools by Measuring Critical Biochemical and Physiological Signals▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of Washington. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(125 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-01, Section: B.
■500 ▼aAdvisor: Patel, Shwetak N.;Seibel, Eric J.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aHealth screening tools that are reliable and accurate have successfully reduced the burden on expensive diagnostic testing along with providing the opportunity of quick, lower cost treatments to a larger community. Designing these tools require interdisciplinary efforts, and in this thesis, author explores development of screening tools for two different bacterial diseases in collaboration with clinicians, researchers, and engineers. Oral Caries and Pulmonary Tuberculosis (TB), bacterial diseases affecting millions across the world, face unique challenges in early disease screening. In the case of oral caries, quantitative screening tools are very limited while in TB screening, the lack of low-cost screening device leaves millions of TB cases undetected. This thesis presents novel sensing techniques based on measuring critical biomarkers, identified with the help of clinicians, that can provide rapid, accurate, quantitative, and non-invasive feedback. Particularly, to reduce gaps in dentistry, thesis focuses on developing tools to measure acidity of oral biofilm. This acidity plays a vital role in the formation of oral caries, yet tools to measure it clinically are absent. O-pH, an optical pH monitoring device is presented that measures the acidity of dental plaque using non-invasive, opto-electronic sensors and provides quantitative feedback of oral health to dentists. The results from in vitro validation and in vivo study with 30 subjects indicate that the device is reliable and accurate. The spot based device is extended to mapping pH using images and a proof-of-concept device built with multimodal-scanning fiber (mm-SFE) is presented. This technology can enable trend based oral health monitoring using pH. In the next part of the thesis, the similar design process is applied to develop a screening tool for TB that focuses on cough as a biomarker. The production of cough in TB patients are primarily in response to changes in lung tissues, which the thesis hypothesizes can result in differences in cough sounds compared to other respiratory health issues. To validate, the author presents, TBscreen, a ResNet-18 model, based on scalogram images of passive coughs. TBscreen was trained and validated using a controlled dataset of passive cough sounds of subjects with TB and other respiratory health ailments. The analysis indicates the sounds from coughing contain disease biomarkers that increases with bacterial load and has the potential to enable large scale screening. Further, results indicate that passive or natural coughs differ from forced coughs, coughs produced on an external prompt, making it difficult to use forced coughs as a proxy for passive coughs. Through development of these two new sensing tools into human subject studies, the author argues that significant contributions have been made to the engineering and medical communities at large.
■590 ▼aSchool code: 0250.
■650 4▼aElectrical engineering.
■650 4▼aComputer engineering.
■650 4▼aBiomedical engineering.
■653 ▼aBacterial diseases
■653 ▼aOral biofilm
■653 ▼aScreening tool
■653 ▼aPulmonary Tuberculosis
■653 ▼aDiagnostic testing
■690 ▼a0544
■690 ▼a0541
■690 ▼a0464
■71020▼aUniversity of Washington▼bElectrical and Computer Engineering.
■7730 ▼tDissertations Abstracts International▼g85-01B.
■773 ▼tDissertation Abstract International
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933320▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
