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Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults- [electronic resource]
Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults - [electronic resource]
Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults- [electronic resource]

Detailed Information

자료유형  
 학위논문파일 국외
최종처리일시  
20240214100104
ISBN  
9798379911812
DDC  
610.73
저자명  
Lathrop, James R.
서명/저자  
Opioids, Cannabis, and Cyclic Vomiting Syndrome in Adults - [electronic resource]
발행사항  
[S.l.]: : University of Washington., 2023
발행사항  
Ann Arbor : : ProQuest Dissertations & Theses,, 2023
형태사항  
1 online resource(129 p.)
주기사항  
Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
주기사항  
Advisor: Heitkemper, Margaret M.;Buchanan, Diana T.
학위논문주기  
Thesis (Ph.D.)--University of Washington, 2023.
사용제한주기  
This item must not be sold to any third party vendors.
초록/해제  
요약Cyclic vomiting syndrome is a rare debilitating illness which is stereotypical to the patient, has an unclear etiology, no biomarkers for diagnosis, and a varied course of illness. The syndrome was first recognized in pediatric patients, and in that population the symptoms generally resolve in puberty, or in a sub-set of those patients continue on into adulthood as a migraine syndrome. Over the past few decades, however, adult cyclic vomiting syndrome has become increasingly recognized with an established set of diagnostic criteria and guidelines for treatment. However, these guidelines and treatment recommendations are based primarily on published case series data and expert opinions, with a very limited number of randomized clinical trials, as well as a correspondingly few systemic reviews or metanalysis of those trials. There have been no prospective longitudinal studies of adult cyclic vomiting patients, and only a few retrospective chart reviews. Overall, however, the gastroenterological literature has been successfully accumulating data around adult cyclic vomiting syndrome as something similar, but distinct from pediatric cyclic vomiting. Then, in 2004, a research group out of South Australia published a case series of 9 patients with chronic daily cannabis use and a relatively classic cyclic vomiting syndrome. They initially identified 19 similar cases, but 5 refused consent, and 5 were excluded on the basis confounders. Of the remaining 9 patients, 8 displayed an affinity for hot water bathing during episodes of active illness, and 2 were able to remain illness free by abstaining from cannabis. They called their newly identified syndrome 'cannabinoid hyperemesis,' and the subsequent two decades the literature witnessed a significant publication interest in the syndrome. Cannabinoid hyperemesis coincided temporally with the decriminalization and legalization of recreational cannabis use in Europe and the Americas. Several elements around this first publication of cannabinoid hyperemesis are particularly interesting. First, the syndrome is counter-intuitive, as delta-9-tetrahydrocannabinol (the primary psychoactive molecule of the cannabis plant) has been a U.S. FDA approved pharmaceutical as an antiemetic and an appetite stimulant since 1985. Second, there was the peculiar behavior of hot water bathing reported in 90% of the sample. Third, the syndrome seemed to mimic cyclic vomiting syndrome. Finally, despite the severity and chronicity of illness expressed by these individuals with cannabinoid hyperemesis, only 2 out of 9 (22%) were able to successfully abstain from cannabis, the causative agent of their illness. Yet this is supported by the literature on cannabis use disorders which is replete with the difficulties in maintaining cannabis abstinence in patients who have fallen into problematic use. Significantly more information is needed on cannabinoid hyperemesis, cannabis use, and cyclic vomiting syndrome. This 2-paper dissertation moves the field of adult cyclic vomiting syndrome and cannabinoid hyperemesis (herein referred to as cannabis hyperemesis syndrome) forward. Presented first is an in-depth narrative review of literature involving both adult cyclic vomiting syndrome and cannabis hyperemesis syndrome. Second is a retrospective chart review (original research) describing the clinical characteristics of 130 cyclic vomiting patients seen at a specialty center within a tertiary care facility in the Pacific Northwest of the United States. 
일반주제명  
Nursing.
일반주제명  
Health sciences.
일반주제명  
French literature.
일반주제명  
Pathology.
키워드  
Cannabis
키워드  
Cannabis hyperemesis syndrome
키워드  
Coalescence
키워드  
Cyclic vomiting syndrome
키워드  
Opioids
기타저자  
University of Washington Nursing
기본자료저록  
Dissertations Abstracts International. 85-01B.
기본자료저록  
Dissertation Abstract International
전자적 위치 및 접속  
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MARC

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■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a610.73
■1001  ▼aLathrop,  James  R.
■24510▼aOpioids,  Cannabis,  and  Cyclic  Vomiting  Syndrome  in  Adults▼h[electronic  resource]
■260    ▼a[S.l.]:▼bUniversity  of  Washington.  ▼c2023
■260  1▼aAnn  Arbor  :▼bProQuest  Dissertations  &  Theses,  ▼c2023
■300    ▼a1  online  resource(129  p.)
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-01,  Section:  B.
■500    ▼aAdvisor:  Heitkemper,  Margaret  M.;Buchanan,  Diana  T.
■5021  ▼aThesis  (Ph.D.)--University  of  Washington,  2023.
■506    ▼aThis  item  must  not  be  sold  to  any  third  party  vendors.
■520    ▼aCyclic  vomiting  syndrome  is  a  rare  debilitating  illness  which  is  stereotypical  to  the  patient,  has  an  unclear  etiology,  no  biomarkers  for  diagnosis,  and  a  varied  course  of  illness.  The  syndrome  was  first  recognized  in  pediatric  patients,  and  in  that  population  the  symptoms  generally  resolve  in  puberty,  or  in  a  sub-set  of  those  patients  continue  on  into  adulthood  as  a  migraine  syndrome.  Over  the  past  few  decades,  however,  adult  cyclic  vomiting  syndrome  has  become  increasingly  recognized  with  an  established  set  of  diagnostic  criteria  and  guidelines  for  treatment.  However,  these  guidelines  and  treatment  recommendations  are  based  primarily  on  published  case  series  data  and  expert  opinions,  with  a  very  limited  number  of  randomized  clinical  trials,  as  well  as  a  correspondingly  few  systemic  reviews  or  metanalysis  of  those  trials.  There  have  been  no  prospective  longitudinal  studies  of  adult  cyclic  vomiting  patients,  and  only  a  few  retrospective  chart  reviews.  Overall,  however,  the  gastroenterological  literature  has  been  successfully  accumulating  data  around  adult  cyclic  vomiting  syndrome  as  something  similar,  but  distinct  from  pediatric  cyclic  vomiting.  Then,  in  2004,  a  research  group  out  of  South  Australia  published  a  case  series  of  9  patients  with  chronic  daily  cannabis  use  and  a  relatively  classic  cyclic  vomiting  syndrome.  They  initially  identified  19  similar  cases,  but  5  refused  consent,  and  5  were  excluded  on  the  basis  confounders.  Of  the  remaining  9  patients,  8  displayed  an  affinity  for  hot  water  bathing  during  episodes  of  active  illness,  and  2  were  able  to  remain  illness  free  by  abstaining  from  cannabis.  They  called  their  newly  identified  syndrome  'cannabinoid  hyperemesis,'  and  the  subsequent  two  decades  the  literature  witnessed  a  significant  publication  interest  in  the  syndrome.  Cannabinoid  hyperemesis  coincided  temporally  with  the  decriminalization  and  legalization  of  recreational  cannabis  use  in  Europe  and  the  Americas.  Several  elements  around  this  first  publication  of  cannabinoid  hyperemesis  are  particularly  interesting.  First,  the  syndrome  is  counter-intuitive,  as  delta-9-tetrahydrocannabinol  (the  primary  psychoactive  molecule  of  the  cannabis  plant)  has  been  a  U.S.  FDA  approved  pharmaceutical  as  an  antiemetic  and  an  appetite  stimulant  since  1985.  Second,  there  was  the  peculiar  behavior  of  hot  water  bathing  reported  in  90%  of  the  sample.  Third,  the  syndrome  seemed  to  mimic  cyclic  vomiting  syndrome.  Finally,  despite  the  severity  and  chronicity  of  illness  expressed  by  these  individuals  with  cannabinoid  hyperemesis,  only  2  out  of  9  (22%)  were  able  to  successfully  abstain  from  cannabis,  the  causative  agent  of  their  illness.  Yet  this  is  supported  by  the  literature  on  cannabis  use  disorders  which  is  replete  with  the  difficulties  in  maintaining  cannabis  abstinence  in  patients  who  have  fallen  into  problematic  use.  Significantly  more  information  is  needed  on  cannabinoid  hyperemesis,  cannabis  use,  and  cyclic  vomiting  syndrome.  This  2-paper  dissertation  moves  the  field  of  adult  cyclic  vomiting  syndrome  and  cannabinoid  hyperemesis  (herein  referred  to  as  cannabis  hyperemesis  syndrome)  forward.  Presented  first  is  an  in-depth  narrative  review  of  literature  involving  both  adult  cyclic  vomiting  syndrome  and  cannabis  hyperemesis  syndrome.  Second  is  a  retrospective  chart  review  (original  research)  describing  the  clinical  characteristics  of  130  cyclic  vomiting  patients  seen  at  a  specialty  center  within  a  tertiary  care  facility  in  the  Pacific  Northwest  of  the  United  States. 
■590    ▼aSchool  code:  0250.
■650  4▼aNursing.
■650  4▼aHealth  sciences.
■650  4▼aFrench  literature.
■650  4▼aPathology.
■653    ▼aCannabis
■653    ▼aCannabis  hyperemesis  syndrome
■653    ▼aCoalescence
■653    ▼aCyclic  vomiting  syndrome
■653    ▼aOpioids
■690    ▼a0569
■690    ▼a0566
■690    ▼a0205
■690    ▼a0571
■71020▼aUniversity  of  Washington▼bNursing.
■7730  ▼tDissertations  Abstracts  International▼g85-01B.
■773    ▼tDissertation  Abstract  International
■790    ▼a0250
■791    ▼aPh.D.
■792    ▼a2023
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931688▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.
■980    ▼a202402▼f2024

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