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Application of Synthetic Antibodies to Biology: The Engineering of Antibody-Based Tools and Therapeutics- [electronic resource]
Application of Synthetic Antibodies to Biology: The Engineering of Antibody-Based Tools and Therapeutics- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100104
- ISBN
- 9798379708498
- DDC
- 574
- 저자명
- Slezak, Tomasz.
- 서명/저자
- Application of Synthetic Antibodies to Biology: The Engineering of Antibody-Based Tools and Therapeutics - [electronic resource]
- 발행사항
- [S.l.]: : The University of Chicago., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(135 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- 주기사항
- Advisor: Kossiakoff, Anthony.
- 학위논문주기
- Thesis (Ph.D.)--The University of Chicago, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Antibodies have the unique property of recognizing and binding specific antigens, making them valuable tools for studying biological processes and developing new disease treatments. The discovery of the technology that allowed for monoclonal antibody production has revolutionized the whole biological field. It has led to the creation of several methods used daily in every modern laboratory. The growing number of antibodies used in the clinic and laboratories require reagent personalization, which usually requires a time-consuming and ineffective chemical manipulation that can influence the antibody's performance. This thesis describes engineering an easy, highthroughput platform that allows for antibody personalization in a plug-and-play fashion. It discusses in detail the protein engineering approach that led to the platform's development, followed by the development of various applications. Finally, the thesis explains the generation of ultra-high affinity antibodies that recognize SARS-CoV-2 and their applications for virus neutralization and detection using the plug-and-play technology described above. The presented technology can potentially improve antibody-based research by the broader scientific community and can revolutionize future clinical approaches for many therapies.
- 일반주제명
- Biochemistry.
- 일반주제명
- Biophysics.
- 일반주제명
- Immunology.
- 키워드
- Cell biology
- 키워드
- Phage display
- 기타저자
- The University of Chicago Biochemistry and Molecular Biophysics
- 기본자료저록
- Dissertations Abstracts International. 84-12B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214100104
■006m o d
■007cr#unu||||||||
■020 ▼a9798379708498
■035 ▼a(MiAaPQ)AAI30418960
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aSlezak, Tomasz.
■24510▼aApplication of Synthetic Antibodies to Biology: The Engineering of Antibody-Based Tools and Therapeutics▼h[electronic resource]
■260 ▼a[S.l.]:▼bThe University of Chicago. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(135 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Kossiakoff, Anthony.
■5021 ▼aThesis (Ph.D.)--The University of Chicago, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aAntibodies have the unique property of recognizing and binding specific antigens, making them valuable tools for studying biological processes and developing new disease treatments. The discovery of the technology that allowed for monoclonal antibody production has revolutionized the whole biological field. It has led to the creation of several methods used daily in every modern laboratory. The growing number of antibodies used in the clinic and laboratories require reagent personalization, which usually requires a time-consuming and ineffective chemical manipulation that can influence the antibody's performance. This thesis describes engineering an easy, highthroughput platform that allows for antibody personalization in a plug-and-play fashion. It discusses in detail the protein engineering approach that led to the platform's development, followed by the development of various applications. Finally, the thesis explains the generation of ultra-high affinity antibodies that recognize SARS-CoV-2 and their applications for virus neutralization and detection using the plug-and-play technology described above. The presented technology can potentially improve antibody-based research by the broader scientific community and can revolutionize future clinical approaches for many therapies.
■590 ▼aSchool code: 0330.
■650 4▼aBiochemistry.
■650 4▼aBiophysics.
■650 4▼aImmunology.
■653 ▼aAntibody engineering
■653 ▼aCell biology
■653 ▼aPhage display
■653 ▼aProtein engineering
■653 ▼aStructural biology
■690 ▼a0487
■690 ▼a0786
■690 ▼a0982
■71020▼aThe University of Chicago▼bBiochemistry and Molecular Biophysics.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0330
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931694▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
