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Gestational Diabetes Mellitus: The Real-World Evidence for Clinical Management and Adverse Health Outcomes in a Multi-Racial/Ethnic Population- [electronic resource]
Gestational Diabetes Mellitus: The Real-World Evidence for Clinical Management and Adverse Health Outcomes in a Multi-Racial/Ethnic Population- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214101705
- ISBN
- 9798380173025
- DDC
- 614.4
- 저자명
- Liu, Xinyue.
- 서명/저자
- Gestational Diabetes Mellitus: The Real-World Evidence for Clinical Management and Adverse Health Outcomes in a Multi-Racial/Ethnic Population - [electronic resource]
- 발행사항
- [S.l.]: : University of California, Los Angeles., 2023
- 발행사항
- Ann Arbor : : ProQuest Dissertations & Theses,, 2023
- 형태사항
- 1 online resource(155 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
- 주기사항
- Advisor: Chen, Liwei.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Los Angeles, 2023.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting of 6-9% pregnancies in the United States (US). It is linked to adverse health outcomes for both mothers and their offspring. There are well-known racial/ethnic differences in GDM prevalence and GDM-related adverse outcomes, but the reasons for the differences remain unknown. For example, Asians have the highest prevalence of GDM, which cannot be explained by the well-established risk factors, such as overweight/obesity and low socioeconomic status. In addition, there is no global consensus on GDM diagnostic methods and cut-offs. Given maternal glucose levels are progressively linked to adverse outcomes, maternal hyperglycemia can be divided into more granular categories than just GDM vs. non-GDM. Regarding adverse health outcomes, it is still unclear whether GDM is associated with neurodevelopmental disorders (NDDs) in offspring and hypertension in mothers.This thesis utilized real-world data from electronic medical records and published cohort studies to answer research questions related to GDM in order to bridge existing research gaps. We found that the more granular maternal hyperglycemic categories also had racial/ethnic differences and distinct health implications. We also found that GDM was associated with NDDs among young offspring born to non-Hispanic White mothers with GDM. Furthermore, GDM was associated with hypertension later in life among mothers.These findings expand the current understanding of GDM diagnosis, GDM management, and GDM-related health implications.
- 일반주제명
- Epidemiology.
- 일반주제명
- Neurosciences.
- 일반주제명
- Obstetrics.
- 키워드
- Pregnancy
- 기타저자
- University of California, Los Angeles Epidemiology 0357
- 기본자료저록
- Dissertations Abstracts International. 85-03B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798380173025
■035 ▼a(MiAaPQ)AAI30635991
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a614.4
■1001 ▼aLiu, Xinyue.
■24510▼aGestational Diabetes Mellitus: The Real-World Evidence for Clinical Management and Adverse Health Outcomes in a Multi-Racial/Ethnic Population▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of California, Los Angeles. ▼c2023
■260 1▼aAnn Arbor :▼bProQuest Dissertations & Theses, ▼c2023
■300 ▼a1 online resource(155 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-03, Section: B.
■500 ▼aAdvisor: Chen, Liwei.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aGestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting of 6-9% pregnancies in the United States (US). It is linked to adverse health outcomes for both mothers and their offspring. There are well-known racial/ethnic differences in GDM prevalence and GDM-related adverse outcomes, but the reasons for the differences remain unknown. For example, Asians have the highest prevalence of GDM, which cannot be explained by the well-established risk factors, such as overweight/obesity and low socioeconomic status. In addition, there is no global consensus on GDM diagnostic methods and cut-offs. Given maternal glucose levels are progressively linked to adverse outcomes, maternal hyperglycemia can be divided into more granular categories than just GDM vs. non-GDM. Regarding adverse health outcomes, it is still unclear whether GDM is associated with neurodevelopmental disorders (NDDs) in offspring and hypertension in mothers.This thesis utilized real-world data from electronic medical records and published cohort studies to answer research questions related to GDM in order to bridge existing research gaps. We found that the more granular maternal hyperglycemic categories also had racial/ethnic differences and distinct health implications. We also found that GDM was associated with NDDs among young offspring born to non-Hispanic White mothers with GDM. Furthermore, GDM was associated with hypertension later in life among mothers.These findings expand the current understanding of GDM diagnosis, GDM management, and GDM-related health implications.
■590 ▼aSchool code: 0031.
■650 4▼aEpidemiology.
■650 4▼aNeurosciences.
■650 4▼aObstetrics.
■653 ▼aGestational diabetes mellitus
■653 ▼aPregnancy
■653 ▼aElectronic medical records
■653 ▼aNeurodevelopmental disorders
■690 ▼a0766
■690 ▼a0317
■690 ▼a0380
■71020▼aUniversity of California, Los Angeles▼bEpidemiology 0357.
■7730 ▼tDissertations Abstracts International▼g85-03B.
■773 ▼tDissertation Abstract International
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16934865▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
