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Node-Pore Sensing Techniques for Biomarker Discovery- [electronic resource]
![Node-Pore Sensing Techniques for Biomarker Discovery - [electronic resource]](/Users/Baul/Images/book.png)
Node-Pore Sensing Techniques for Biomarker Discovery- [electronic resource]
상세정보
- 자료유형
- 학위논문파일 국외
- 최종처리일시
- 20240214100319
- ISBN
- 9798380619721
- DDC
- 610
- 저자명
- Li, Brian.
- 서명/저자
- Node-Pore Sensing Techniques for Biomarker Discovery - [electronic resource]
- 발행사항
- [S.l.]: : University of California, Berkeley., 2021
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2021
- 형태사항
- 1 online resource(95 p.)
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
- 주기사항
- Advisor: Sohn, Lydia L.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2021.
- 사용제한주기
- This item must not be sold to any third party vendors.
- 초록/해제
- 요약Microfluidic technologies have in conjunction with the field of biomedical research for their utility in making highly precise measurements of biological and chemical specimens. These measurements help us search for specific analytes that can be associated with biological states such as disease in a process called biomarker discovery. The analytes in question are the biomarkers of the states they represent, and these associations become part of the greater body of knowledge that guide other researchers in the recognition and study of other biological phenomena. Eventually, this work helps guide clinicians in making diagnostic and prognostic decisions. In this dissertation, I will describe work done to engineer and implement two microfluidic technologies designed to perform biomarker discovery via different modalities, albeit with both analyzing single-cell phenotypes. The first of these devices, called mechano-node-pore sensing, focused on the mechanical properties of cells, and how the mechanics of the cell as a material can reveal information about drug resistance in acute promyelocytic leukemia. The second of these devices instead analyzed cells for surface proteins using a novel scheme for chemical immobilization of antibody probes. In both cases, I demonstrate how mechanical properties and surface proteins can be used as biomarkers to discriminate between cell phenotypes, and how such measurements can help us more deeply understand a variety of biological phenomena, and eventually make advancements in biomedicine.
- 일반주제명
- Biomedical engineering.
- 일반주제명
- Cellular biology.
- 일반주제명
- Bioengineering.
- 키워드
- Biomedicine
- 키워드
- Cell phenotypes
- 기타저자
- University of California, Berkeley Bioengineering
- 기본자료저록
- Dissertations Abstracts International. 85-04B.
- 기본자료저록
- Dissertation Abstract International
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520240214100319
■006m o d
■007cr#unu||||||||
■020 ▼a9798380619721
■035 ▼a(MiAaPQ)AAI28869866
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aLi, Brian.
■24510▼aNode-Pore Sensing Techniques for Biomarker Discovery▼h[electronic resource]
■260 ▼a[S.l.]:▼bUniversity of California, Berkeley. ▼c2021
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2021
■300 ▼a1 online resource(95 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-04, Section: B.
■500 ▼aAdvisor: Sohn, Lydia L.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2021.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aMicrofluidic technologies have in conjunction with the field of biomedical research for their utility in making highly precise measurements of biological and chemical specimens. These measurements help us search for specific analytes that can be associated with biological states such as disease in a process called biomarker discovery. The analytes in question are the biomarkers of the states they represent, and these associations become part of the greater body of knowledge that guide other researchers in the recognition and study of other biological phenomena. Eventually, this work helps guide clinicians in making diagnostic and prognostic decisions. In this dissertation, I will describe work done to engineer and implement two microfluidic technologies designed to perform biomarker discovery via different modalities, albeit with both analyzing single-cell phenotypes. The first of these devices, called mechano-node-pore sensing, focused on the mechanical properties of cells, and how the mechanics of the cell as a material can reveal information about drug resistance in acute promyelocytic leukemia. The second of these devices instead analyzed cells for surface proteins using a novel scheme for chemical immobilization of antibody probes. In both cases, I demonstrate how mechanical properties and surface proteins can be used as biomarkers to discriminate between cell phenotypes, and how such measurements can help us more deeply understand a variety of biological phenomena, and eventually make advancements in biomedicine.
■590 ▼aSchool code: 0028.
■650 4▼aBiomedical engineering.
■650 4▼aCellular biology.
■650 4▼aBioengineering.
■653 ▼aMicrofluidic technologies
■653 ▼aChemical specimens
■653 ▼aBiological specimens
■653 ▼aBiomedicine
■653 ▼aCell phenotypes
■690 ▼a0541
■690 ▼a0379
■690 ▼a0202
■71020▼aUniversity of California, Berkeley▼bBioengineering.
■7730 ▼tDissertations Abstracts International▼g85-04B.
■773 ▼tDissertation Abstract International
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2021
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931874▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
