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Actigraphy and Symptom Changes With a Social Rhythm Intervention in Young Persons With Mood Disorders
Actigraphy and Symptom Changes With a Social Rhythm Intervention in Young Persons With Moo...
Actigraphy and Symptom Changes With a Social Rhythm Intervention in Young Persons With Mood Disorders

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20250211151049
ISBN  
9798382321332
DDC  
610
저자명  
de Queiroz Campos, Gabriela.
서명/저자  
Actigraphy and Symptom Changes With a Social Rhythm Intervention in Young Persons With Mood Disorders
발행사항  
[Sl] : Yale University, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
50 p
주기사항  
Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
주기사항  
Advisor: Blumberg, Hilary P.
학위논문주기  
Thesis (D.Med.)--Yale University, 2024.
초록/해제  
요약Irregularities in rest and activity patterns are being increasingly recognized to play important roles in symptoms of major mood disorders, such as bipolar disorder (BD) and major depressive disorder (MDD). Passive measures obtained from digital wearable actigraph devices have potential to provide scalable methods sensitive to behavioral and symptom changes that could be informative in identifying worsening and assessing effects of interventions. Use in younger individuals can be particularly helpful for identifying targets for early detection, allowing for potential reduction of disorder progression. Through this investigation, we aimed to assess changes in actigraphic measures of rest and activity patterns and mood disorder symptoms in adolescents and young adults with and at familial risk for a mood disorder receiving a telehealth social rhythm therapy (SRT) that provides individuals strategies to regularize their daily routines. Further, we aimed to assess for any associations between these changes in symptoms and actigraphic measures.Seven adolescents and young adults with and at risk for a mood disorder, ages 14-29 years, participated in a protocol that included measures of behaviors and clinical symptoms (i.e., social rhythm stability, depressive symptoms, and suicide propensity), actigraphic recording generating measures of daily rest and activity patterns (i.e. interdaily stability [IS] and relative amplitude [RA]), and a 12-week telehealth SRT intervention through the Brain Emotion circuitry targeted Self-Monitoring and Regulation Therapy for daily rhythm regularization (BE-SMART-DR). Daily rhythm stability was assessed using the self-administered Brief Social Rhythm Scale (BSRS), as well as the BSRS items exclusively pertaining to stability of sleep and wake times (BSRS4). Symptoms of depression were assessed by the investigator-rated Hamilton Depression Rating Scale (HAMD), and suicide propensity was assessed using the self-reported Concise Health Risk Tracking Scale (CHRT). Actigraphic recording was done using GENEActiv actigraphy watch-like devices during the first two and last two weeks of BE-SMART-DR. The GGIR RStudio processing package was used to collect data on IS and RA. Changes in symptom and behavioral ratings and actigraphy measures pre- and post-BE-SMART-DR intervention, and associations among these changes were assessed.It was hypothesized that participants would show improvement in social rhythm stability, depression, and suicide propensity, as well as actigraphic measures of IS and RA. Further, it was also hypothesized that improvements in actigraphy measures would be associated with those in behaviors and symptoms. Namely, improvements in RA and IS would be associated with improvement in depression, and improvement in IS would be associated with improvement in BSRS4.Following intervention with BE-SMART-DR, participants showed significant improvements in BSRS (p0.05), HAMD (p0.01), and CHRT (p0.05). There were improvements in BSRS4, IS, and RA over the intervention, but these did not reach statistical significance. While associations did not reach statistical significance in this sample, associations of percent increases in IS and percent decrease in HAMD were of strong (Pearson correlation r = -0.65), and of medium effect size with percent decrease in BSRS4 (Pearson correlation r = -0.34). The findings of this preliminary investigation suggest that telehealth-administered SRT, BE-SMART-DR, can reduce social rhythm irregularities, depressive symptoms, and suicide propensity in adolescents and young adults with and at risk for mood disorders. Actigraphic measures of daily rest and activity pattern stability may provide a way to collect data in a passive and scalable way about pattern regularity that may also reflect improvements in depression. While findings of this study in this modest sample did not reach significance, effect sizes suggest promise in this ongoing investigation.
일반주제명  
Medicine
일반주제명  
Psychology
일반주제명  
Mental health
키워드  
Actigraphy
키워드  
Bipolar disorder
키워드  
Daily rhythm
키워드  
Major depressive disorder
키워드  
Young adults
키워드  
Social rhythm therapy
기타저자  
Yale University Yale School of Medicine
기본자료저록  
Dissertations Abstracts International. 85-11B.
전자적 위치 및 접속  
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MARC

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■1001  ▼ade  Queiroz  Campos,  Gabriela.
■24510▼aActigraphy  and  Symptom  Changes  With  a  Social  Rhythm  Intervention  in  Young  Persons  With  Mood  Disorders
■260    ▼a[Sl]▼bYale  University▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a50  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-11,  Section:  B.
■500    ▼aAdvisor:  Blumberg,  Hilary  P.
■5021  ▼aThesis  (D.Med.)--Yale  University,  2024.
■520    ▼aIrregularities  in  rest  and  activity  patterns  are  being  increasingly  recognized  to  play  important  roles  in  symptoms  of  major  mood  disorders,  such  as  bipolar  disorder  (BD)  and  major  depressive  disorder  (MDD).  Passive  measures  obtained  from  digital  wearable  actigraph  devices  have  potential  to  provide  scalable  methods  sensitive  to  behavioral  and  symptom  changes  that  could  be  informative  in  identifying  worsening  and  assessing  effects  of  interventions.  Use  in  younger  individuals  can  be  particularly  helpful  for  identifying  targets  for  early  detection,  allowing  for  potential  reduction  of  disorder  progression.  Through  this  investigation,  we  aimed  to  assess  changes  in  actigraphic  measures  of  rest  and  activity  patterns  and  mood  disorder  symptoms  in  adolescents  and  young  adults  with  and  at  familial  risk  for  a  mood  disorder  receiving  a  telehealth  social  rhythm  therapy  (SRT)  that  provides  individuals  strategies  to  regularize  their  daily  routines.  Further,  we  aimed  to  assess  for  any  associations  between  these  changes  in  symptoms  and  actigraphic  measures.Seven  adolescents  and  young  adults  with  and  at  risk  for  a  mood  disorder,  ages  14-29  years,  participated  in  a  protocol  that  included  measures  of  behaviors  and  clinical  symptoms  (i.e.,  social  rhythm  stability,  depressive  symptoms,  and  suicide  propensity), actigraphic  recording  generating  measures  of  daily  rest  and  activity  patterns  (i.e.  interdaily  stability  [IS]  and  relative  amplitude  [RA]),  and  a  12-week  telehealth  SRT  intervention  through  the  Brain  Emotion  circuitry  targeted  Self-Monitoring  and  Regulation  Therapy  for  daily  rhythm  regularization  (BE-SMART-DR).  Daily  rhythm  stability  was  assessed  using  the  self-administered  Brief  Social  Rhythm  Scale  (BSRS),  as  well  as  the  BSRS  items  exclusively  pertaining  to  stability  of  sleep  and  wake  times  (BSRS4).  Symptoms  of  depression  were  assessed  by  the  investigator-rated  Hamilton  Depression  Rating  Scale  (HAMD),  and  suicide  propensity  was  assessed  using  the  self-reported  Concise  Health  Risk  Tracking  Scale  (CHRT).  Actigraphic  recording  was  done  using  GENEActiv  actigraphy  watch-like  devices  during  the  first  two  and  last  two  weeks  of  BE-SMART-DR.  The  GGIR  RStudio  processing  package  was  used  to  collect  data  on  IS  and  RA.  Changes  in  symptom  and  behavioral  ratings  and  actigraphy  measures  pre-  and  post-BE-SMART-DR  intervention,  and  associations  among  these  changes  were  assessed.It  was  hypothesized  that  participants  would  show  improvement  in  social  rhythm  stability,  depression,  and  suicide  propensity,  as  well  as  actigraphic  measures  of  IS  and  RA.  Further,  it  was  also  hypothesized  that  improvements  in  actigraphy  measures  would  be  associated  with  those  in  behaviors  and  symptoms.  Namely,  improvements  in  RA  and  IS  would  be  associated  with  improvement  in  depression,  and  improvement  in  IS  would  be  associated  with  improvement  in  BSRS4.Following  intervention  with  BE-SMART-DR,  participants  showed  significant  improvements  in  BSRS  (p0.05),  HAMD  (p0.01),  and  CHRT  (p0.05).  There  were  improvements  in  BSRS4,  IS,  and  RA  over  the  intervention,  but  these  did  not  reach  statistical  significance.  While  associations  did  not  reach  statistical  significance  in  this sample,  associations  of  percent  increases  in  IS  and  percent  decrease  in  HAMD  were  of  strong  (Pearson  correlation  r  =  -0.65),  and  of  medium  effect  size  with  percent  decrease  in  BSRS4  (Pearson  correlation  r  =  -0.34). The  findings  of  this  preliminary  investigation  suggest  that  telehealth-administered  SRT,  BE-SMART-DR,  can  reduce  social  rhythm  irregularities,  depressive  symptoms,  and  suicide  propensity  in  adolescents  and  young  adults  with  and  at  risk  for  mood  disorders.  Actigraphic  measures  of  daily  rest  and  activity  pattern  stability  may  provide  a  way  to  collect  data  in  a  passive  and  scalable  way  about  pattern  regularity  that  may  also  reflect  improvements  in  depression.  While  findings  of  this  study  in  this  modest  sample  did  not  reach  significance,  effect  sizes  suggest  promise  in  this  ongoing  investigation.
■590    ▼aSchool  code:  0265.
■650  4▼aMedicine
■650  4▼aPsychology
■650  4▼aMental  health
■653    ▼aActigraphy
■653    ▼aBipolar  disorder
■653    ▼aDaily  rhythm
■653    ▼aMajor  depressive  disorder
■653    ▼aYoung  adults
■653    ▼aSocial  rhythm  therapy
■690    ▼a0564
■690    ▼a0621
■690    ▼a0347
■71020▼aYale  University▼bYale  School  of  Medicine.
■7730  ▼tDissertations  Abstracts  International▼g85-11B.
■790    ▼a0265
■791    ▼aD.Med.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160614▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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