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Novel Regulation and Functions of AMPK in Developing and Adult Neurons
Novel Regulation and Functions of AMPK in Developing and Adult Neurons
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151056
- ISBN
- 9798382346526
- DDC
- 616
- 서명/저자
- Novel Regulation and Functions of AMPK in Developing and Adult Neurons
- 발행사항
- [Sl] : Columbia University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 371 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Polleux, Franck.
- 학위논문주기
- Thesis (Ph.D.)--Columbia University, 2024.
- 초록/해제
- 요약The AMP-activated protein kinase (AMPK) is a master metabolic regulator and energy sensor that has been extensively studied in the context of cancer and metabolic disorders. However, its role in neuronal function and morphology remains largely unexplored. This dissertation aims to bridge this gap by investigating the roles of AMPK in maintaining axon homeostasis and regulating mitochondrial morphology in neurons. By identifying novel regulators of AMPK across different cellular compartments, this thesis sheds light on the multifaceted functions of AMPK in shaping neuronal and mitochondrial architecture. The dissertation is organized into five chapters. Chapter 1 provides a brief background on AMPK, its activation mechanisms, and the downstream pathways it regulates. Chapter 2 introduces with-no-lysine kinase (WNK), a novel axon morphogenic kinase with dual roles in terminal axon branch development and maintenance in mature axons. Chapter 3 investigates the role of AMPK in mediating the loss-of-WNK axonal phenotypes, revealing a critical link between AMPK and axonal integrity. Chapter 4 shifts focus to the mitochondrial, characterizing mitochondrial fission regulator 1-like (MTFR1L) as a novel AMPK-activated protein that regulates mitochondrial morphology. Finally, Chapter 5 explores the role of AMPK in mediating activity-dependent mitochondrial morphology in hippocampal CA1 neurons, highlighting the dynamic interplay between neuronal activity and mitochondrial dynamics. Collectively, these findings provide novel insights into the multifaceted roles of AMPK in neuronal development, degeneration, and organelle regulation, underscoring the importance of this master kinase in maintaining neuronal health and homeostasis.
- 일반주제명
- Neurosciences
- 일반주제명
- Medicine
- 일반주제명
- Molecular biology
- 일반주제명
- Biochemistry
- 키워드
- Energy sensor
- 키워드
- Axon development
- 기타저자
- Columbia University Neurobiology and Behavior
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151056
■006m o d
■007cr#unu||||||||
■020 ▼a9798382346526
■035 ▼a(MiAaPQ)AAI31142264
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aHamilton, Stevie.
■24510▼aNovel Regulation and Functions of AMPK in Developing and Adult Neurons
■260 ▼a[Sl]▼bColumbia University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a371 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Polleux, Franck.
■5021 ▼aThesis (Ph.D.)--Columbia University, 2024.
■520 ▼aThe AMP-activated protein kinase (AMPK) is a master metabolic regulator and energy sensor that has been extensively studied in the context of cancer and metabolic disorders. However, its role in neuronal function and morphology remains largely unexplored. This dissertation aims to bridge this gap by investigating the roles of AMPK in maintaining axon homeostasis and regulating mitochondrial morphology in neurons. By identifying novel regulators of AMPK across different cellular compartments, this thesis sheds light on the multifaceted functions of AMPK in shaping neuronal and mitochondrial architecture. The dissertation is organized into five chapters. Chapter 1 provides a brief background on AMPK, its activation mechanisms, and the downstream pathways it regulates. Chapter 2 introduces with-no-lysine kinase (WNK), a novel axon morphogenic kinase with dual roles in terminal axon branch development and maintenance in mature axons. Chapter 3 investigates the role of AMPK in mediating the loss-of-WNK axonal phenotypes, revealing a critical link between AMPK and axonal integrity. Chapter 4 shifts focus to the mitochondrial, characterizing mitochondrial fission regulator 1-like (MTFR1L) as a novel AMPK-activated protein that regulates mitochondrial morphology. Finally, Chapter 5 explores the role of AMPK in mediating activity-dependent mitochondrial morphology in hippocampal CA1 neurons, highlighting the dynamic interplay between neuronal activity and mitochondrial dynamics. Collectively, these findings provide novel insights into the multifaceted roles of AMPK in neuronal development, degeneration, and organelle regulation, underscoring the importance of this master kinase in maintaining neuronal health and homeostasis.
■590 ▼aSchool code: 0054.
■650 4▼aNeurosciences
■650 4▼aMedicine
■650 4▼aMolecular biology
■650 4▼aBiochemistry
■653 ▼aEnergy sensor
■653 ▼aAxon degeneration
■653 ▼aAxon development
■653 ▼aMitochondrial morphology
■653 ▼aWallerian degeneration
■690 ▼a0317
■690 ▼a0487
■690 ▼a0564
■690 ▼a0307
■71020▼aColumbia University▼bNeurobiology and Behavior.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0054
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160656▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
