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Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20250211151328
ISBN  
9798382830445
DDC  
310
저자명  
Nandy, Sagnik.
서명/저자  
Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
발행사항  
[Sl] : University of Pennsylvania, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
224 p
주기사항  
Source: Dissertations Abstracts International, Volume: 85-12, Section: A.
주기사항  
Advisor: Bhattacharya, Bhaswar B.;Ma, Zongming.
학위논문주기  
Thesis (Ph.D.)--University of Pennsylvania, 2024.
초록/해제  
요약Multimodal data analysis has garnered considerable attention in data science due to its wide applicability across several scientific disciplines. However, developing efficient and statistically sound procedures for information integration in multimodal datasets remains a challenge. In this dissertation, we tackle the multimodal data integration problem using a variant of the Approximate Message Passing algorithm introduced in Donoho et al. (2009). Our variant not only matches popularly used techniques in accuracy but also allows for statistical inference with the results of the algorithm, thanks to an exact asymptotic characterization of the estimation error. Such a feature facilitating statistical inference with the results generated from a data integration algorithm is not widely available in the literature. Moreover, the signal reconstruction risk of our algorithm is provably Bayes optimal which enhances its appeal.This dissertation is structured into three parts. In the first part, we introduce the algorithm and discuss its mathematical properties. In the second part, we apply this algorithm to delineate the phase transition threshold for community detection in Contextual Stochastic Block Models introduced in Deshpande et. al (2018). This application demonstrates the algorithm's efficiency in optimally integrating information across network data and node features. In the final part, we first develop a data-adaptive version of the algorithm and use it to develop a data integration procedure useful to integrate information across single-cell multi-omic datasets. Furthermore, we also develop a technique to map query data points with partially observed modalities to the integrated embeddings constructed using the training data with high confidence. In real data, our method competes with state-of-art integration techniques used in single-cell multi-omic data analysis, in terms of effective construction of cell atlases that segregate different cell types into interpretable clusters. Moreover, this method also provides an avenue to map new query cells with partially observed features to such atlases.
일반주제명  
Statistics
일반주제명  
Statistical physics
일반주제명  
Applied mathematics
일반주제명  
Information science
키워드  
Approximate Message Passing
키워드  
Data integration
키워드  
Multimodal Data
키워드  
Single-cell multi-omic datasets
키워드  
Minimum mean square error
기타저자  
University of Pennsylvania Statistics and Data Science
기본자료저록  
Dissertations Abstracts International. 85-12A.
전자적 위치 및 접속  
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MARC

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■1001  ▼aNandy,  Sagnik.
■24510▼aOrchestrated  Approximate  Message  Passing:  A  Novel  Way  of  Multimodal  Data  Integration
■260    ▼a[Sl]▼bUniversity  of  Pennsylvania▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a224  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-12,  Section:  A.
■500    ▼aAdvisor:  Bhattacharya,  Bhaswar  B.;Ma,  Zongming.
■5021  ▼aThesis  (Ph.D.)--University  of  Pennsylvania,  2024.
■520    ▼aMultimodal  data  analysis  has  garnered  considerable  attention  in  data  science  due  to  its  wide  applicability  across  several  scientific  disciplines.  However,  developing  efficient  and  statistically  sound  procedures  for  information  integration  in  multimodal  datasets  remains  a  challenge.  In  this  dissertation,  we  tackle  the  multimodal  data  integration  problem  using  a  variant  of  the  Approximate  Message  Passing  algorithm  introduced  in  Donoho  et  al.  (2009).  Our  variant  not  only  matches  popularly  used  techniques  in  accuracy  but  also  allows  for  statistical  inference  with  the  results  of  the  algorithm,  thanks  to  an  exact  asymptotic  characterization  of  the  estimation  error.  Such  a  feature  facilitating  statistical  inference  with  the  results  generated  from  a  data  integration  algorithm  is  not  widely  available  in  the  literature.  Moreover,  the  signal  reconstruction  risk  of  our  algorithm  is  provably  Bayes  optimal  which  enhances  its  appeal.This  dissertation  is  structured  into  three  parts.  In  the  first  part,  we  introduce  the  algorithm  and  discuss  its  mathematical  properties.  In  the  second  part,  we  apply  this  algorithm  to  delineate  the  phase  transition  threshold  for  community  detection  in  Contextual  Stochastic  Block  Models  introduced  in  Deshpande  et.  al  (2018).  This  application  demonstrates  the  algorithm's  efficiency  in  optimally  integrating  information  across  network  data  and  node  features.  In  the  final  part,  we  first  develop  a  data-adaptive  version  of  the  algorithm  and  use  it  to  develop  a  data  integration  procedure  useful  to  integrate  information  across  single-cell  multi-omic  datasets.  Furthermore,  we  also  develop  a  technique  to  map  query  data  points  with  partially  observed  modalities  to  the  integrated  embeddings  constructed  using  the  training  data  with  high  confidence.  In  real  data,  our  method  competes  with  state-of-art  integration  techniques  used  in  single-cell  multi-omic  data  analysis,  in  terms  of  effective  construction  of  cell  atlases  that  segregate  different  cell  types  into  interpretable  clusters.  Moreover,  this  method  also  provides  an  avenue  to  map  new  query  cells  with  partially  observed  features  to  such  atlases.
■590    ▼aSchool  code:  0175.
■650  4▼aStatistics
■650  4▼aStatistical  physics
■650  4▼aApplied  mathematics
■650  4▼aInformation  science
■653    ▼aApproximate  Message  Passing
■653    ▼aData  integration
■653    ▼aMultimodal  Data
■653    ▼aSingle-cell  multi-omic  datasets
■653    ▼aMinimum  mean  square  error
■690    ▼a0463
■690    ▼a0217
■690    ▼a0723
■690    ▼a0364
■71020▼aUniversity  of  Pennsylvania▼bStatistics  and  Data  Science.
■7730  ▼tDissertations  Abstracts  International▼g85-12A.
■790    ▼a0175
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161236▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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