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Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151328
- ISBN
- 9798382830445
- DDC
- 310
- 저자명
- Nandy, Sagnik.
- 서명/저자
- Orchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
- 발행사항
- [Sl] : University of Pennsylvania, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 224 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: A.
- 주기사항
- Advisor: Bhattacharya, Bhaswar B.;Ma, Zongming.
- 학위논문주기
- Thesis (Ph.D.)--University of Pennsylvania, 2024.
- 초록/해제
- 요약Multimodal data analysis has garnered considerable attention in data science due to its wide applicability across several scientific disciplines. However, developing efficient and statistically sound procedures for information integration in multimodal datasets remains a challenge. In this dissertation, we tackle the multimodal data integration problem using a variant of the Approximate Message Passing algorithm introduced in Donoho et al. (2009). Our variant not only matches popularly used techniques in accuracy but also allows for statistical inference with the results of the algorithm, thanks to an exact asymptotic characterization of the estimation error. Such a feature facilitating statistical inference with the results generated from a data integration algorithm is not widely available in the literature. Moreover, the signal reconstruction risk of our algorithm is provably Bayes optimal which enhances its appeal.This dissertation is structured into three parts. In the first part, we introduce the algorithm and discuss its mathematical properties. In the second part, we apply this algorithm to delineate the phase transition threshold for community detection in Contextual Stochastic Block Models introduced in Deshpande et. al (2018). This application demonstrates the algorithm's efficiency in optimally integrating information across network data and node features. In the final part, we first develop a data-adaptive version of the algorithm and use it to develop a data integration procedure useful to integrate information across single-cell multi-omic datasets. Furthermore, we also develop a technique to map query data points with partially observed modalities to the integrated embeddings constructed using the training data with high confidence. In real data, our method competes with state-of-art integration techniques used in single-cell multi-omic data analysis, in terms of effective construction of cell atlases that segregate different cell types into interpretable clusters. Moreover, this method also provides an avenue to map new query cells with partially observed features to such atlases.
- 일반주제명
- Statistics
- 일반주제명
- Statistical physics
- 일반주제명
- Applied mathematics
- 일반주제명
- Information science
- 키워드
- Data integration
- 키워드
- Multimodal Data
- 기타저자
- University of Pennsylvania Statistics and Data Science
- 기본자료저록
- Dissertations Abstracts International. 85-12A.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798382830445
■035 ▼a(MiAaPQ)AAI31240441
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a310
■1001 ▼aNandy, Sagnik.
■24510▼aOrchestrated Approximate Message Passing: A Novel Way of Multimodal Data Integration
■260 ▼a[Sl]▼bUniversity of Pennsylvania▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a224 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: A.
■500 ▼aAdvisor: Bhattacharya, Bhaswar B.;Ma, Zongming.
■5021 ▼aThesis (Ph.D.)--University of Pennsylvania, 2024.
■520 ▼aMultimodal data analysis has garnered considerable attention in data science due to its wide applicability across several scientific disciplines. However, developing efficient and statistically sound procedures for information integration in multimodal datasets remains a challenge. In this dissertation, we tackle the multimodal data integration problem using a variant of the Approximate Message Passing algorithm introduced in Donoho et al. (2009). Our variant not only matches popularly used techniques in accuracy but also allows for statistical inference with the results of the algorithm, thanks to an exact asymptotic characterization of the estimation error. Such a feature facilitating statistical inference with the results generated from a data integration algorithm is not widely available in the literature. Moreover, the signal reconstruction risk of our algorithm is provably Bayes optimal which enhances its appeal.This dissertation is structured into three parts. In the first part, we introduce the algorithm and discuss its mathematical properties. In the second part, we apply this algorithm to delineate the phase transition threshold for community detection in Contextual Stochastic Block Models introduced in Deshpande et. al (2018). This application demonstrates the algorithm's efficiency in optimally integrating information across network data and node features. In the final part, we first develop a data-adaptive version of the algorithm and use it to develop a data integration procedure useful to integrate information across single-cell multi-omic datasets. Furthermore, we also develop a technique to map query data points with partially observed modalities to the integrated embeddings constructed using the training data with high confidence. In real data, our method competes with state-of-art integration techniques used in single-cell multi-omic data analysis, in terms of effective construction of cell atlases that segregate different cell types into interpretable clusters. Moreover, this method also provides an avenue to map new query cells with partially observed features to such atlases.
■590 ▼aSchool code: 0175.
■650 4▼aStatistics
■650 4▼aStatistical physics
■650 4▼aApplied mathematics
■650 4▼aInformation science
■653 ▼aApproximate Message Passing
■653 ▼aData integration
■653 ▼aMultimodal Data
■653 ▼aSingle-cell multi-omic datasets
■653 ▼aMinimum mean square error
■690 ▼a0463
■690 ▼a0217
■690 ▼a0723
■690 ▼a0364
■71020▼aUniversity of Pennsylvania▼bStatistics and Data Science.
■7730 ▼tDissertations Abstracts International▼g85-12A.
■790 ▼a0175
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161236▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.


