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Integrative Precision Medicine Approach to Dissect Patient Heterogeneity in Systemic Lupus Erythematosus
Integrative Precision Medicine Approach to Dissect Patient Heterogeneity in Systemic Lupus Erythematosus
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151353
- ISBN
- 9798382814315
- DDC
- 574
- 저자명
- Cutts, Zachary.
- 서명/저자
- Integrative Precision Medicine Approach to Dissect Patient Heterogeneity in Systemic Lupus Erythematosus
- 발행사항
- [Sl] : University of California, San Francisco, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 69 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Sirota, Marina.
- 학위논문주기
- Thesis (Ph.D.)--University of California, San Francisco, 2024.
- 초록/해제
- 요약Autoimmune diseases arise from dysregulation of the immune system, leading to its attack on the body's own tissues and organs. The clinical heterogeneity of these diseases arises from several sources, such as genetic predisposition, environmental triggers, and aberrant immune responses. One emerging area of interest is the role of transposable elements (TEs) in autoimmune disease pathogenesis because these self-nucleic acids can be mistakenly detected as foreign, which can trigger a chronic immune reaction.There is growing appreciation for the role of TEs in systemic lupus erythematosus (SLE) and studies have found differentially expressed TEs in SLE patients, which suggests a link between TE activity and disease mechanisms. Our work investigated TE expression in four immune cell types from SLE patients, revealing cell-specific and SLE subphenotype-specific differentially expressed TEs, with additional cell-type-specific TE associations in different ancestry groups. TE expression was also associated with host gene expression involved in antiviral and immune responses, supporting the hypothesis that TEs could activate the innate immune system and contribute to chronic inflammation and autoimmunity.This study underscores the importance of TEs in SLE heterogeneity and highlights the need for further exploration of TE expression in normal immune cells and functional studies to understand their role in SLE pathogenesis. Future work to study whether antiretroviral drugs could reduce expression of TEs and mitigate SLE symptoms is warranted, given the potential involvement of TEs in autoimmune disease pathogenesis.
- 일반주제명
- Bioinformatics
- 일반주제명
- Biology
- 일반주제명
- Medicine
- 일반주제명
- Immunology
- 키워드
- Autoimmunity
- 키워드
- Retroviruses
- 기타저자
- University of California, San Francisco Biological and Medical Informatics
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798382814315
■035 ▼a(MiAaPQ)AAI31243484
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aCutts, Zachary.▼0(orcid)0000-0001-7180-6608
■24510▼aIntegrative Precision Medicine Approach to Dissect Patient Heterogeneity in Systemic Lupus Erythematosus
■260 ▼a[Sl]▼bUniversity of California, San Francisco▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a69 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Sirota, Marina.
■5021 ▼aThesis (Ph.D.)--University of California, San Francisco, 2024.
■520 ▼aAutoimmune diseases arise from dysregulation of the immune system, leading to its attack on the body's own tissues and organs. The clinical heterogeneity of these diseases arises from several sources, such as genetic predisposition, environmental triggers, and aberrant immune responses. One emerging area of interest is the role of transposable elements (TEs) in autoimmune disease pathogenesis because these self-nucleic acids can be mistakenly detected as foreign, which can trigger a chronic immune reaction.There is growing appreciation for the role of TEs in systemic lupus erythematosus (SLE) and studies have found differentially expressed TEs in SLE patients, which suggests a link between TE activity and disease mechanisms. Our work investigated TE expression in four immune cell types from SLE patients, revealing cell-specific and SLE subphenotype-specific differentially expressed TEs, with additional cell-type-specific TE associations in different ancestry groups. TE expression was also associated with host gene expression involved in antiviral and immune responses, supporting the hypothesis that TEs could activate the innate immune system and contribute to chronic inflammation and autoimmunity.This study underscores the importance of TEs in SLE heterogeneity and highlights the need for further exploration of TE expression in normal immune cells and functional studies to understand their role in SLE pathogenesis. Future work to study whether antiretroviral drugs could reduce expression of TEs and mitigate SLE symptoms is warranted, given the potential involvement of TEs in autoimmune disease pathogenesis.
■590 ▼aSchool code: 0034.
■650 4▼aBioinformatics
■650 4▼aBiology
■650 4▼aMedicine
■650 4▼aImmunology
■653 ▼aAutoimmunity
■653 ▼aRetroviruses
■653 ▼aSystemic lupus erythematosus
■653 ▼aTransposable elements
■653 ▼aAutoimmune diseases
■690 ▼a0715
■690 ▼a0306
■690 ▼a0564
■690 ▼a0982
■71020▼aUniversity of California, San Francisco▼bBiological and Medical Informatics.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0034
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161419▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
