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Correlates of Hypersomnolence Disorder During Nocturnal Sleep
Correlates of Hypersomnolence Disorder During Nocturnal Sleep
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152033
- ISBN
- 9798383198056
- DDC
- 150
- 저자명
- Cook, Jesse D.
- 서명/저자
- Correlates of Hypersomnolence Disorder During Nocturnal Sleep
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 259 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
- 주기사항
- Advisor: Plante, David T.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
- 초록/해제
- 요약Hypersomnolence, defined as excessive daytime sleepiness with normal to prolonged sleep duration, is a common sleep problem. Many patients experience hypersomnolence without an overarching explanation ("unexplained hypersomnolence"). Hypersomnolence disorder (HD) is the DSM-5 classifier for unexplained hypersomnolence. HD is poorly understood and disproportionately understudied. This project was designed to advance the understanding of HD by identifying nocturnal sleep correlates, while focusing on two components key to sleep restoration: slow waves and sleep stage stability (SSS). We examined differences between unmedicated HD (N = 60) and healthy control (N = 29) samples across normalized slow wave activity (SWA), slow wave characteristics (SWC) (incidence, pre- and post-slope, and peak amplitude), and SSS features (median bout duration, number of sleep stage bouts, number of transitions between stages, and sleep stage survival) from nocturnal polysomnography using 6-channel electroencephalography. Focal analyses corresponded to all-night data. Exploratory analyses analyzed sleep cycle-specific data and relationships between focal outcomes and hypersomnolence measures. The moderating role of depression on focal relationships was also evaluated. Post-hoc analyses assessed differences in SWC across low- and high-amplitude (≥40μV) slow waves. Participants were predominantly female, white, and non-Hispanic/Latinx. Nocturnal sleep correlates of HD were observed across all project components. HD displayed reduced SWA in frontal and central regions, with the most pronounced reductions in the left-hemisphere frontal channel (F3). HD displayed alterations across all SWC. Differential dynamics were observed between low- and high-amplitude SWC analyses. Also, SWC patterns differed regionally, with directionality in occipital channels differing from frontal and central channels for all- and low-amplitude SWC analyses. HD displayed enhanced SSS features (e.g., longer bout durations, better survival for deeper sleep stages, and decreased number of stage bouts/transitions between stages). Our results corroborate previous SWA reduction findings in HD and suggest regional slow wave enhancement as a potential therapeutic strategy. Current models of sleep-wake regulation and state transitioning were not fully sufficient to explain the project's findings and HD symptomatology generally (i.e., sleep inertia). Future models that consider arousal as a continuum, rather than a binary framework, may be fruitful theoretical considerations. To close, a novel developmental hypothesis HD is proposed, based on project findings.
- 일반주제명
- Psychology
- 일반주제명
- Mental health
- 일반주제명
- Medicine
- 일반주제명
- Clinical psychology
- 키워드
- Depression
- 키워드
- Hypersomnia
- 키워드
- Hypersomnolence
- 키워드
- Slow wave sleep
- 기타저자
- The University of Wisconsin - Madison Psychology
- 기본자료저록
- Dissertations Abstracts International. 86-01B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211152033
■006m o d
■007cr#unu||||||||
■020 ▼a9798383198056
■035 ▼a(MiAaPQ)AAI31334693
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a150
■1001 ▼aCook, Jesse D.
■24510▼aCorrelates of Hypersomnolence Disorder During Nocturnal Sleep
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a259 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-01, Section: B.
■500 ▼aAdvisor: Plante, David T.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
■520 ▼aHypersomnolence, defined as excessive daytime sleepiness with normal to prolonged sleep duration, is a common sleep problem. Many patients experience hypersomnolence without an overarching explanation ("unexplained hypersomnolence"). Hypersomnolence disorder (HD) is the DSM-5 classifier for unexplained hypersomnolence. HD is poorly understood and disproportionately understudied. This project was designed to advance the understanding of HD by identifying nocturnal sleep correlates, while focusing on two components key to sleep restoration: slow waves and sleep stage stability (SSS). We examined differences between unmedicated HD (N = 60) and healthy control (N = 29) samples across normalized slow wave activity (SWA), slow wave characteristics (SWC) (incidence, pre- and post-slope, and peak amplitude), and SSS features (median bout duration, number of sleep stage bouts, number of transitions between stages, and sleep stage survival) from nocturnal polysomnography using 6-channel electroencephalography. Focal analyses corresponded to all-night data. Exploratory analyses analyzed sleep cycle-specific data and relationships between focal outcomes and hypersomnolence measures. The moderating role of depression on focal relationships was also evaluated. Post-hoc analyses assessed differences in SWC across low- and high-amplitude (≥40μV) slow waves. Participants were predominantly female, white, and non-Hispanic/Latinx. Nocturnal sleep correlates of HD were observed across all project components. HD displayed reduced SWA in frontal and central regions, with the most pronounced reductions in the left-hemisphere frontal channel (F3). HD displayed alterations across all SWC. Differential dynamics were observed between low- and high-amplitude SWC analyses. Also, SWC patterns differed regionally, with directionality in occipital channels differing from frontal and central channels for all- and low-amplitude SWC analyses. HD displayed enhanced SSS features (e.g., longer bout durations, better survival for deeper sleep stages, and decreased number of stage bouts/transitions between stages). Our results corroborate previous SWA reduction findings in HD and suggest regional slow wave enhancement as a potential therapeutic strategy. Current models of sleep-wake regulation and state transitioning were not fully sufficient to explain the project's findings and HD symptomatology generally (i.e., sleep inertia). Future models that consider arousal as a continuum, rather than a binary framework, may be fruitful theoretical considerations. To close, a novel developmental hypothesis HD is proposed, based on project findings.
■590 ▼aSchool code: 0262.
■650 4▼aPsychology
■650 4▼aMental health
■650 4▼aMedicine
■650 4▼aClinical psychology
■653 ▼aDaytime sleepiness
■653 ▼aDepression
■653 ▼aHypersomnia
■653 ▼aHypersomnolence
■653 ▼aSleep stage stability
■653 ▼aSlow wave sleep
■690 ▼a0621
■690 ▼a0347
■690 ▼a0564
■690 ▼a0622
■71020▼aThe University of Wisconsin - Madison▼bPsychology.
■7730 ▼tDissertations Abstracts International▼g86-01B.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162614▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
