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5-MeO-DMT as a Mental Health Tool: Exploring Possible Mechanisms of Action, the Reactivation Phenomenon, and Historical-Cultural Perspectives on Its Use
5-MeO-DMT as a Mental Health Tool: Exploring Possible Mechanisms of Action, the Reactivati...
5-MeO-DMT as a Mental Health Tool: Exploring Possible Mechanisms of Action, the Reactivation Phenomenon, and Historical-Cultural Perspectives on Its Use

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자료유형  
 학위논문 서양
최종처리일시  
20250211152800
ISBN  
9798383684801
DDC  
150
저자명  
Ortiz Bernal, Ana Maria.
서명/저자  
5-MeO-DMT as a Mental Health Tool: Exploring Possible Mechanisms of Action, the Reactivation Phenomenon, and Historical-Cultural Perspectives on Its Use
발행사항  
[Sl] : The University of Wisconsin - Madison, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
229 p
주기사항  
Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
주기사항  
Advisor: Raison, Charles.
학위논문주기  
Thesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
초록/해제  
요약The short-acting psychedelic 5-MeO-DMT is gaining attention as a novel treatment for psychiatric disorders. Given the current interest in this substance, this dissertation investigated three different relevant aspects related to 5-MeO-DMT. Manuscript 1 examined potential psychological mechanisms underlying 5-MeO-DMT's therapeutic effects. A cross-sectional survey of participants (n = 90, Mean age = 38.8) assessed changes in the psychological constructs of cognitive fusion, nature relatedness, and prosocial behavioral intentions before and after 5-MeO-DMT use. Significant decreases in cognitive fusion and increases in nature relatedness and prosocial intentions were noted, particularly associated with challenging and insightful experiences.Manuscript 2 explored the prevalence, predictors, and emotional valence of a complex and poorly understood phenomenon known as "reactivations" following 5-MeO-DMT use (n = 90, Mean age = 38.8). Reactivations were found to be common and predominantly experienced as positive or neutral events. Predictors of reactivation experiences were the amount of time planned ahead for a 5-MeO-DMT dose, and decreases in cognitive fusion from before-to-after 5-MeO-DMT use. Psychological insight effects were associated with greater likelihood of reactivations being perceived positively, while challenging effects were associated with lower likelihood of positive/neutral emotional valence.Manuscript 3 provided a comprehensive historical and cultural analysis of 5-MeO-DMT use, tracing its origins to ancient South American Indigenous practices. It also examined the symbolic significance of a toad motif among Mesoamerican cultures, and discussed modern applications of toad-derived 5-MeO-DMT in North America and globally. This historical-cultural perspective provides crucial context for understanding the current therapeutic interest in 5-MeO-DMT and the ethical considerations surrounding its use and sourcing.Taken together, this dissertation's findings contribute to the scientific literature on 5- MeO-DMT's potential psychological mechanisms of action, and provide helpful data regarding the reactivation phenomenon. Additionally, it provides a comprehensive historical-cultural perspective on 5-MeO-DMT use from ancient practices to modern applications, offering insights into the evolving cultural and societal perceptions of this compound and its potential role as a mental health tool.
일반주제명  
Psychology
일반주제명  
Latin American literature
일반주제명  
Mental health
일반주제명  
Clinical psychology
키워드  
5-Methoxy-N,N-dimethyltryptamine
키워드  
Cognitive fusion
키워드  
Ego dissolution
키워드  
Nature relatedness
키워드  
Prosocial behaviors
키워드  
Well-being
기타저자  
The University of Wisconsin - Madison Human Ecology
기본자료저록  
Dissertations Abstracts International. 86-02B.
전자적 위치 및 접속  
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■1001  ▼aOrtiz  Bernal,  Ana  Maria.
■24510▼a5-MeO-DMT  as  a  Mental  Health  Tool:  Exploring  Possible  Mechanisms  of  Action,  the  Reactivation  Phenomenon,  and  Historical-Cultural  Perspectives  on  Its  Use
■260    ▼a[Sl]▼bThe  University  of  Wisconsin  -  Madison▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a229  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  86-02,  Section:  B.
■500    ▼aAdvisor:  Raison,  Charles.
■5021  ▼aThesis  (Ph.D.)--The  University  of  Wisconsin  -  Madison,  2024.
■520    ▼aThe  short-acting  psychedelic  5-MeO-DMT  is  gaining  attention  as  a  novel  treatment  for  psychiatric  disorders.  Given  the  current  interest  in  this  substance,  this  dissertation  investigated  three  different  relevant  aspects  related  to  5-MeO-DMT.  Manuscript  1  examined  potential  psychological  mechanisms  underlying  5-MeO-DMT's  therapeutic  effects.  A  cross-sectional  survey  of  participants  (n  =  90,  Mean  age  =  38.8)  assessed  changes  in  the  psychological  constructs  of  cognitive  fusion,  nature  relatedness,  and  prosocial  behavioral  intentions  before  and  after  5-MeO-DMT  use.  Significant  decreases  in  cognitive  fusion  and  increases  in  nature  relatedness  and  prosocial  intentions  were  noted,  particularly  associated  with  challenging  and  insightful  experiences.Manuscript  2  explored  the  prevalence,  predictors,  and  emotional  valence  of  a  complex  and  poorly  understood  phenomenon  known  as  "reactivations"  following  5-MeO-DMT  use  (n  =  90,  Mean  age  =  38.8).  Reactivations  were  found  to  be  common  and  predominantly  experienced  as  positive  or  neutral  events.  Predictors  of  reactivation  experiences  were  the  amount  of  time  planned  ahead  for  a  5-MeO-DMT  dose,  and  decreases  in  cognitive  fusion  from  before-to-after  5-MeO-DMT  use.  Psychological  insight  effects  were  associated  with  greater  likelihood  of  reactivations  being  perceived  positively,  while  challenging  effects  were  associated  with  lower  likelihood  of  positive/neutral  emotional  valence.Manuscript  3  provided  a  comprehensive  historical  and  cultural  analysis  of  5-MeO-DMT  use,  tracing  its  origins  to  ancient  South  American  Indigenous  practices.  It  also  examined  the  symbolic  significance  of  a  toad  motif  among  Mesoamerican  cultures,  and  discussed  modern  applications  of  toad-derived  5-MeO-DMT  in  North  America  and  globally.  This  historical-cultural  perspective  provides  crucial  context  for  understanding  the  current  therapeutic  interest  in  5-MeO-DMT  and  the  ethical  considerations  surrounding  its  use  and  sourcing.Taken  together,  this  dissertation's  findings  contribute  to  the  scientific  literature  on  5-  MeO-DMT's  potential  psychological  mechanisms  of  action,  and  provide  helpful  data  regarding  the  reactivation  phenomenon.  Additionally,  it  provides  a  comprehensive  historical-cultural  perspective  on  5-MeO-DMT  use  from  ancient  practices  to  modern  applications,  offering  insights  into  the  evolving  cultural  and  societal  perceptions  of  this  compound  and  its  potential  role  as  a  mental  health  tool.
■590    ▼aSchool  code:  0262.
■650  4▼aPsychology
■650  4▼aLatin  American  literature
■650  4▼aMental  health
■650  4▼aClinical  psychology
■653    ▼a5-Methoxy-N,N-dimethyltryptamine
■653    ▼aCognitive  fusion
■653    ▼aEgo  dissolution
■653    ▼aNature  relatedness
■653    ▼aProsocial  behaviors
■653    ▼aWell-being
■690    ▼a0621
■690    ▼a0312
■690    ▼a0622
■690    ▼a0347
■71020▼aThe  University  of  Wisconsin  -  Madison▼bHuman  Ecology.
■7730  ▼tDissertations  Abstracts  International▼g86-02B.
■790    ▼a0262
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163841▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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