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Neural Basis of Spatial, Contextual, and Temporal Memory in the Retrosplenial Cortex
Neural Basis of Spatial, Contextual, and Temporal Memory in the Retrosplenial Cortex
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152037
- ISBN
- 9798384049685
- DDC
- 616
- 서명/저자
- Neural Basis of Spatial, Contextual, and Temporal Memory in the Retrosplenial Cortex
- 발행사항
- [Sl] : Cornell University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 169 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Smith, David.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2024.
- 초록/해제
- 요약The Retrosplenial cortex (RSC) is a brain region which plays an important role in spatial navigation and has also been shown to be involved in episodic memory in humans. Although several studies have shown the involvement of the RSC in various cognitive functions, still a lot remains to be understood about its information coding mechanisms. In this work, I examine the RSC firing patterns underlying its functions in spatial, contextual, and temporal memory. RSC is interconnected with the Hippocampus (HPC), which is also involved in similar functions. Even though both the regions are involved in navigation-related firing, there has been little work directly comparing the information coding mechanisms of these two brain regions. To address this, I examined the similarities and differences in spatial and contextual firing patterns in the two regions and found that even when encoding the same type of navigational information, they used different coding schemes. Also, head direction was prominently encoded by the RSC but not by the HPC. The results show that the RSC and HPC make related, but somewhat different contributions to spatial cognition. RSC lesions have been shown to cause impairment in temporal memory but the neuronal firing patterns supporting it have not been studied. I addressed this by analyzing archival RSC neuronal firing data during the intertrial delay period from two behavioral tasks with different memory demands. I discovered time cells in the RSC, and they are sensitive to the memory demands of the task. This suggests that temporal coding is a prominent feature of the RSC firing patterns. Lesion studies have found that the RSC is also necessary for spatial working memory tasks but the firing patterns underlying it remain unknown. To address this, I analysed the firing activity of RSC neurons while rats held spatial information in memory over the delay period of a spatial alternation task. I found that the RSC neurons exhibited reliably different firing patterns throughout the delay periods preceding each trial type, suggesting that these firing patterns represent critical memory information underlying the role of the RSC in spatial working memory.
- 일반주제명
- Neurosciences
- 일반주제명
- Physiology
- 키워드
- Memory
- 기타저자
- Cornell University Psychological Sciences and Human Development
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798384049685
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aSubramanian, Dev Laxman.▼0(orcid)0000-0002-2019-264X
■24510▼aNeural Basis of Spatial, Contextual, and Temporal Memory in the Retrosplenial Cortex
■260 ▼a[Sl]▼bCornell University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a169 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Smith, David.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2024.
■520 ▼aThe Retrosplenial cortex (RSC) is a brain region which plays an important role in spatial navigation and has also been shown to be involved in episodic memory in humans. Although several studies have shown the involvement of the RSC in various cognitive functions, still a lot remains to be understood about its information coding mechanisms. In this work, I examine the RSC firing patterns underlying its functions in spatial, contextual, and temporal memory. RSC is interconnected with the Hippocampus (HPC), which is also involved in similar functions. Even though both the regions are involved in navigation-related firing, there has been little work directly comparing the information coding mechanisms of these two brain regions. To address this, I examined the similarities and differences in spatial and contextual firing patterns in the two regions and found that even when encoding the same type of navigational information, they used different coding schemes. Also, head direction was prominently encoded by the RSC but not by the HPC. The results show that the RSC and HPC make related, but somewhat different contributions to spatial cognition. RSC lesions have been shown to cause impairment in temporal memory but the neuronal firing patterns supporting it have not been studied. I addressed this by analyzing archival RSC neuronal firing data during the intertrial delay period from two behavioral tasks with different memory demands. I discovered time cells in the RSC, and they are sensitive to the memory demands of the task. This suggests that temporal coding is a prominent feature of the RSC firing patterns. Lesion studies have found that the RSC is also necessary for spatial working memory tasks but the firing patterns underlying it remain unknown. To address this, I analysed the firing activity of RSC neurons while rats held spatial information in memory over the delay period of a spatial alternation task. I found that the RSC neurons exhibited reliably different firing patterns throughout the delay periods preceding each trial type, suggesting that these firing patterns represent critical memory information underlying the role of the RSC in spatial working memory.
■590 ▼aSchool code: 0058.
■650 4▼aNeurosciences
■650 4▼aPhysiology
■653 ▼aElectrophysiology
■653 ▼aMemory
■653 ▼aRetrosplenial cortex
■690 ▼a0317
■690 ▼a0719
■71020▼aCornell University▼bPsychological Sciences and Human Development.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162653▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
