서브메뉴
검색
Development of a Structure-Function Toolbox for Synthesis of Bioinspired Polymeric Catalysts
Development of a Structure-Function Toolbox for Synthesis of Bioinspired Polymeric Catalysts
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152038
- ISBN
- 9798383690901
- DDC
- 547
- 서명/저자
- Development of a Structure-Function Toolbox for Synthesis of Bioinspired Polymeric Catalysts
- 발행사항
- [Sl] : The University of North Carolina at Chapel Hill, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 263 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
- 주기사항
- Advisor: Knight, Abigail S.
- 학위논문주기
- Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.
- 초록/해제
- 요약Proteins are extraordinary materials that perform a variety of functions stemming from biology, such as catalysis and analyte binding. These functions originate from protein's unique ability to form precise structures, placing residues in conformations beneficial to their function. These structures can span multiple length scales, from single molecules to assemblies of proteins. However, applications of these materials outside of native biological environments are a challenge, making industrial-scale synthesis and use of proteins often costly. Synthetic macromolecules, on the other hand, have diverse stability and functionality as well as scalable syntheses. However, the study of the hierarchical structures of synthetic macromolecules and their impact on biomimetic functions is comparatively underexplored.Catalysis is a facile method to understand how differences in polymer structure impacts function as rates of reaction can easily be extracted from yield information to glean information about how changing polymer properties impacts the rate of catalysis. Herein we have approached the development of palladium bound triphenylphosphine-containing polymer catalysts and analyzed their reactivity using a model Suzuki-Miyaura cross-coupling reaction modifying polymer properties such as molecular weight and comonomer (Chapter 2). Additionally, we have analyzed the addition of protein-mimetic functional groups, including local structure and electrostatic interactions, as well as incorporation of a bis-phosphine monomer to study the impact of metal-ligand cross-links on these novel polymeric materials (Chapter 3). Further, we endeavored to add strong architectural differences to these materials via the incorporation of covalent cross-linking as well as branching to study the effect of compaction and changes in backbone architecture on catalysis (Appendix A). Lastly, I have endeavored using other biomimetic materials such as peptoids and peptide-polymer amphiphiles to gain information about how the composition of these materials leads to changes in structure and therefore function through multichain assemblies (Appendix B and Appendix C respectively). Together these multifaceted approaches have enhanced our understanding of the structure-function relationships of synthetic macromolecules and have begun bridging the gap between the functionality of synthetic macromolecules and the precise hierarchical structure of biological materials.
- 일반주제명
- Polymer chemistry
- 일반주제명
- Organic chemistry
- 일반주제명
- Chemistry
- 일반주제명
- Molecular biology
- 일반주제명
- Biochemistry
- 키워드
- Proteins
- 기타저자
- The University of North Carolina at Chapel Hill Chemistry
- 기본자료저록
- Dissertations Abstracts International. 86-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008250123s2024 us c eng d■001000017162654
■00520250211152038
■006m o d
■007cr#unu||||||||
■020 ▼a9798383690901
■035 ▼a(MiAaPQ)AAI31335800
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a547
■1001 ▼aSanders, Matthew Alan.
■24510▼aDevelopment of a Structure-Function Toolbox for Synthesis of Bioinspired Polymeric Catalysts
■260 ▼a[Sl]▼bThe University of North Carolina at Chapel Hill▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a263 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-02, Section: B.
■500 ▼aAdvisor: Knight, Abigail S.
■5021 ▼aThesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.
■520 ▼aProteins are extraordinary materials that perform a variety of functions stemming from biology, such as catalysis and analyte binding. These functions originate from protein's unique ability to form precise structures, placing residues in conformations beneficial to their function. These structures can span multiple length scales, from single molecules to assemblies of proteins. However, applications of these materials outside of native biological environments are a challenge, making industrial-scale synthesis and use of proteins often costly. Synthetic macromolecules, on the other hand, have diverse stability and functionality as well as scalable syntheses. However, the study of the hierarchical structures of synthetic macromolecules and their impact on biomimetic functions is comparatively underexplored.Catalysis is a facile method to understand how differences in polymer structure impacts function as rates of reaction can easily be extracted from yield information to glean information about how changing polymer properties impacts the rate of catalysis. Herein we have approached the development of palladium bound triphenylphosphine-containing polymer catalysts and analyzed their reactivity using a model Suzuki-Miyaura cross-coupling reaction modifying polymer properties such as molecular weight and comonomer (Chapter 2). Additionally, we have analyzed the addition of protein-mimetic functional groups, including local structure and electrostatic interactions, as well as incorporation of a bis-phosphine monomer to study the impact of metal-ligand cross-links on these novel polymeric materials (Chapter 3). Further, we endeavored to add strong architectural differences to these materials via the incorporation of covalent cross-linking as well as branching to study the effect of compaction and changes in backbone architecture on catalysis (Appendix A). Lastly, I have endeavored using other biomimetic materials such as peptoids and peptide-polymer amphiphiles to gain information about how the composition of these materials leads to changes in structure and therefore function through multichain assemblies (Appendix B and Appendix C respectively). Together these multifaceted approaches have enhanced our understanding of the structure-function relationships of synthetic macromolecules and have begun bridging the gap between the functionality of synthetic macromolecules and the precise hierarchical structure of biological materials.
■590 ▼aSchool code: 0153.
■650 4▼aPolymer chemistry
■650 4▼aOrganic chemistry
■650 4▼aChemistry
■650 4▼aMolecular biology
■650 4▼aBiochemistry
■653 ▼aPolymer catalysts
■653 ▼aStructure-function relationships
■653 ▼aSuzuki-miyaura cross-couplings
■653 ▼aProteins
■653 ▼aBiological materials
■690 ▼a0495
■690 ▼a0490
■690 ▼a0487
■690 ▼a0307
■690 ▼a0485
■71020▼aThe University of North Carolina at Chapel Hill▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g86-02B.
■790 ▼a0153
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162654▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
