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An Ultrasound Based Femoral Artery Calcification Score Predicts Amputation Free Survival
An Ultrasound Based Femoral Artery Calcification Score Predicts Amputation Free Survival
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151107
- ISBN
- 9798382321288
- DDC
- 617
- 저자명
- Maahs, Ethan.
- 서명/저자
- An Ultrasound Based Femoral Artery Calcification Score Predicts Amputation Free Survival
- 발행사항
- [Sl] : Yale University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 42 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Guzman, Raul J.
- 학위논문주기
- Thesis (M.D.)--Yale University, 2024.
- 초록/해제
- 요약Objectives: Duplex ultrasound (DUS) of the lower extremities is commonly used to assess patients with lower extremity atherosclerosis. Arterial calcification can often be visualized in these images, however efforts to quantify its extent have been limited. We thus sought to develop a new scoring system to measure calcification on duplex US studies of the femoral artery and correlate it with standard CT-based methods. We then made preliminary attempts to correlate US-based femoral artery calcification scores with limb-specific outcomes in patients with peripheral artery disease.Methods: Patients who underwent CT scan evaluation of the lower extremities and arterial duplex US of either lower extremity within 6 months of one another were included in the study. CT based calcium scores of the femoral artery were generated using calcium scoring software. To determine an ultrasound score, 5 standard arterial segments (common femoral artery, proximal superficial femoral artery (SFA), mid SFA, distal SFA, and above knee popliteal artery) were scored using a scale of 0 - 2 where 0 signified a completely normal vessel segment, 1 was a vessel with hyperechoic irregularities of the vessel wall, and 2 was assigned to images with clear anechoic shadowing. The available scores were then averaged to yield a single femoral calcium score for each leg. Predictors of femoral calcification scores were then assessed and compared with CT-based methods. The correlation between US and CT based femoral calcification was assessed, and then the association between the US-based femoral calcification score and limb outcomes was evaluated.Results: A total of 113 patients met the inclusion criteria and were included in the final analysis. US based calcification scores were increased in patients with diabetes, renal failure, and the present of chronic limb threatening ischemia in a manner that was similar to CT-based femoral calcification. US and CT-based calcification scores showed a moderate-strong correlation (r=.64). An elevated US-based femoral artery calcification score was associated with decreased amputation free survival. Conclusions: A novel US-based methods shows promise as a simple method for quantifying the extent of femoral artery calcification in patients with PAD. It correlates with standard CT-based methods. Preliminary studies show that it may be useful for predicating outcomes in patients with PAD.
- 일반주제명
- Surgery
- 일반주제명
- Biomedical engineering
- 일반주제명
- Medical imaging
- 키워드
- Ultrasound score
- 기타저자
- Schwartz, Andrew
- 기타저자
- Berezowitz, Alexa
- 기타저자
- Davis, Sean
- 기타저자
- Guzman, Raul J.
- 기타저자
- Yale University Yale School of Medicine
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008250123s2024 us c eng d■001000017160725
■00520250211151107
■006m o d
■007cr#unu||||||||
■020 ▼a9798382321288
■035 ▼a(MiAaPQ)AAI31143756
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a617
■1001 ▼aMaahs, Ethan.
■24513▼aAn Ultrasound Based Femoral Artery Calcification Score Predicts Amputation Free Survival
■260 ▼a[Sl]▼bYale University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a42 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Guzman, Raul J.
■5021 ▼aThesis (M.D.)--Yale University, 2024.
■520 ▼aObjectives: Duplex ultrasound (DUS) of the lower extremities is commonly used to assess patients with lower extremity atherosclerosis. Arterial calcification can often be visualized in these images, however efforts to quantify its extent have been limited. We thus sought to develop a new scoring system to measure calcification on duplex US studies of the femoral artery and correlate it with standard CT-based methods. We then made preliminary attempts to correlate US-based femoral artery calcification scores with limb-specific outcomes in patients with peripheral artery disease.Methods: Patients who underwent CT scan evaluation of the lower extremities and arterial duplex US of either lower extremity within 6 months of one another were included in the study. CT based calcium scores of the femoral artery were generated using calcium scoring software. To determine an ultrasound score, 5 standard arterial segments (common femoral artery, proximal superficial femoral artery (SFA), mid SFA, distal SFA, and above knee popliteal artery) were scored using a scale of 0 - 2 where 0 signified a completely normal vessel segment, 1 was a vessel with hyperechoic irregularities of the vessel wall, and 2 was assigned to images with clear anechoic shadowing. The available scores were then averaged to yield a single femoral calcium score for each leg. Predictors of femoral calcification scores were then assessed and compared with CT-based methods. The correlation between US and CT based femoral calcification was assessed, and then the association between the US-based femoral calcification score and limb outcomes was evaluated.Results: A total of 113 patients met the inclusion criteria and were included in the final analysis. US based calcification scores were increased in patients with diabetes, renal failure, and the present of chronic limb threatening ischemia in a manner that was similar to CT-based femoral calcification. US and CT-based calcification scores showed a moderate-strong correlation (r=.64). An elevated US-based femoral artery calcification score was associated with decreased amputation free survival. Conclusions: A novel US-based methods shows promise as a simple method for quantifying the extent of femoral artery calcification in patients with PAD. It correlates with standard CT-based methods. Preliminary studies show that it may be useful for predicating outcomes in patients with PAD.
■590 ▼aSchool code: 0265.
■650 4▼aSurgery
■650 4▼aBiomedical engineering
■650 4▼aMedical imaging
■653 ▼aDuplex ultrasound
■653 ▼aLower extremity atherosclerosis
■653 ▼aSuperficial femoral artery
■653 ▼aUltrasound score
■690 ▼a0576
■690 ▼a0541
■690 ▼a0574
■70010▼aSchwartz, Andrew▼ejoint author
■70010▼aBerezowitz, Alexa▼ejoint author
■70010▼aDavis, Sean▼ejoint author
■70010▼aGuzman, Raul J.▼ejoint author
■71020▼aYale University▼bYale School of Medicine.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0265
■791 ▼aM.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160725▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
