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Cortical Reactivations Predict Future Sensory Responses
Cortical Reactivations Predict Future Sensory Responses
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152818
- ISBN
- 9798346567448
- DDC
- 616
- 서명/저자
- Cortical Reactivations Predict Future Sensory Responses
- 발행사항
- [Sl] : Harvard University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 103 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
- 주기사항
- Advisor: Andermann, Mark.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2024.
- 초록/해제
- 요약Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium activity of thousands of excitatory neurons in the mouse lateral visual cortex. During the minute after a visual stimulus, we observed transient, stimulus-specific reactivations, often coupled with hippocampal sharp-wave ripples. Stimulus-specific reactivations were abolished by local cortical silencing during the preceding stimulus. Reactivations early in a session systematically differed from the pattern evoked by the previous stimulus-they were more similar to future stimulus response patterns, thereby predicting both within-day and across-day representational drift. In particular, neurons that participated proportionally more or less in early stimulus reactivations than in stimulus response patterns gradually increased or decreased their future stimulus responses, respectively. Indeed, we could accurately predict future changes in stimulus responses and the separation of responses to distinct stimuli using only the rate and content of reactivations. Thus, reactivations may contribute to a gradual drift and separation in sensory cortical response patterns, thereby enhancing sensory discrimination.
- 일반주제명
- Neurosciences
- 일반주제명
- Physiology
- 일반주제명
- Cognitive psychology
- 키워드
- Consolidation
- 키워드
- Learning
- 키워드
- Memory
- 키워드
- Replay
- 키워드
- Visual cortex
- 기타저자
- Harvard University Medical Sciences
- 기본자료저록
- Dissertations Abstracts International. 86-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
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■020 ▼a9798346567448
■035 ▼a(MiAaPQ)AAI31558984
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aNguyen, Nghia Dinh.▼0(orcid)0000-0002-6197-7806
■24510▼aCortical Reactivations Predict Future Sensory Responses
■260 ▼a[Sl]▼bHarvard University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a103 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-05, Section: B.
■500 ▼aAdvisor: Andermann, Mark.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2024.
■520 ▼aMany theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium activity of thousands of excitatory neurons in the mouse lateral visual cortex. During the minute after a visual stimulus, we observed transient, stimulus-specific reactivations, often coupled with hippocampal sharp-wave ripples. Stimulus-specific reactivations were abolished by local cortical silencing during the preceding stimulus. Reactivations early in a session systematically differed from the pattern evoked by the previous stimulus-they were more similar to future stimulus response patterns, thereby predicting both within-day and across-day representational drift. In particular, neurons that participated proportionally more or less in early stimulus reactivations than in stimulus response patterns gradually increased or decreased their future stimulus responses, respectively. Indeed, we could accurately predict future changes in stimulus responses and the separation of responses to distinct stimuli using only the rate and content of reactivations. Thus, reactivations may contribute to a gradual drift and separation in sensory cortical response patterns, thereby enhancing sensory discrimination.
■590 ▼aSchool code: 0084.
■650 4▼aNeurosciences
■650 4▼aPhysiology
■650 4▼aCognitive psychology
■653 ▼aConsolidation
■653 ▼aLearning
■653 ▼aMemory
■653 ▼aReplay
■653 ▼aVisual cortex
■690 ▼a0317
■690 ▼a0633
■690 ▼a0719
■71020▼aHarvard University▼bMedical Sciences.
■7730 ▼tDissertations Abstracts International▼g86-05B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163992▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
