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Advances in Image Reconstruction for Digital Breast Tomosynthesis
Advances in Image Reconstruction for Digital Breast Tomosynthesis
Advances in Image Reconstruction for Digital Breast Tomosynthesis

상세정보

자료유형  
 학위논문 서양
최종처리일시  
20250211152102
ISBN  
9798382739755
DDC  
610
저자명  
Gao, Mingjie.
서명/저자  
Advances in Image Reconstruction for Digital Breast Tomosynthesis
발행사항  
[Sl] : University of Michigan, 2024
발행사항  
Ann Arbor : ProQuest Dissertations & Theses, 2024
형태사항  
171 p
주기사항  
Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
주기사항  
Advisor: Chan, Heang-Ping;Fessler, Jeffrey A.
학위논문주기  
Thesis (Ph.D.)--University of Michigan, 2024.
초록/해제  
요약Digital breast tomosynthesis (DBT) is an important imaging modality for breast cancer screening and diagnosis. It acquires a sequence of projection views within a limited angle and provides quasi-three-dimensional images of the breasts, allowing for improved lesion visualization and reduced false positives compared with two-dimensional mammography. Despite its advantages, DBT suffers from noise and blur problems that can compromise image quality and reduce its sensitivity in detecting subtle signs of breast cancer such as microcalcifications (MCs). The primary objective of this thesis is to push the state-of-the-art of DBT imaging by developing advanced DBT image reconstruction and processing methods. By reducing image noise, enhancing spatial resolution, optimizing reconstruction methods and evaluating them based on clinical tasks, our ultimate goal is to make DBT an even more effective tool for breast cancer screening and diagnosis. In this thesis, we first developed a deep convolutional neural network (DCNN) for denoising reconstructed DBT images. We trained the DCNN using a weighted combination of mean squared error loss and the adversarial loss based on generative adversarial network (GAN), and therefore called it DNGAN. The DNGAN improved the contrast-to-noise ratio, detectability index, and human observer detection sensitivity of the MCs in DBT images of breast simulating phantoms. Promising denoising results were also observed on a small test set of human subject DBTs. Then, we introduced a model-based DCNN-regularized reconstruction (MDR) method for DBT. It combined a model-based iterative reconstruction method with the DNGAN denoiser. To facilitate task-based image quality assessment, we also proposed two DCNN tools: CNN-NE for noise estimation, and CNN-MC as a model observer for MC cluster detectability measure. We demonstrated the effectiveness of CNN-NE and CNN-MC using phantom DBTs. The MDR method achieved low noise and the highest detection rankings on a test set of human subject DBTs. Finally, we presented our work on modeling the x-ray source motion blur of the DBT imaging system. We derived an analytical in-plane source blur kernel for DBT images based on imaging geometry and showed that it could be approximated by a shift-invariant kernel over the DBT slice at a given height above the detector. We proposed a post-processing image deblurring method with a generative diffusion model as an image prior and successfully enhanced spatial resolution of the reconstructed DBT images.
일반주제명  
Biomedical engineering
일반주제명  
Computer science
일반주제명  
Electrical engineering
일반주제명  
Computer engineering
키워드  
Digital breast tomosynthesis
키워드  
Image reconstruction
키워드  
Deep learning
키워드  
Image processing
키워드  
Microcalcification
키워드  
Image quality evaluation
기타저자  
University of Michigan Electrical and Computer Engineering
기본자료저록  
Dissertations Abstracts International. 85-12B.
전자적 위치 및 접속  
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MARC

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■1001  ▼aGao,  Mingjie.
■24510▼aAdvances  in  Image  Reconstruction  for  Digital  Breast  Tomosynthesis
■260    ▼a[Sl]▼bUniversity  of  Michigan▼c2024
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2024
■300    ▼a171  p
■500    ▼aSource:  Dissertations  Abstracts  International,  Volume:  85-12,  Section:  B.
■500    ▼aAdvisor:  Chan,  Heang-Ping;Fessler,  Jeffrey  A.
■5021  ▼aThesis  (Ph.D.)--University  of  Michigan,  2024.
■520    ▼aDigital  breast  tomosynthesis  (DBT)  is  an  important  imaging  modality  for  breast  cancer  screening  and  diagnosis.  It  acquires  a  sequence  of  projection  views  within  a  limited  angle  and  provides  quasi-three-dimensional  images  of  the  breasts,  allowing  for  improved  lesion  visualization  and  reduced  false  positives  compared  with  two-dimensional  mammography.  Despite  its  advantages,  DBT  suffers  from  noise  and  blur  problems  that  can  compromise  image  quality  and  reduce  its  sensitivity  in  detecting  subtle  signs  of  breast  cancer  such  as  microcalcifications  (MCs).  The  primary  objective  of  this  thesis  is  to  push  the  state-of-the-art  of  DBT  imaging  by  developing  advanced  DBT  image  reconstruction  and  processing  methods.  By  reducing  image  noise,  enhancing  spatial  resolution,  optimizing  reconstruction  methods  and  evaluating  them  based  on  clinical  tasks,  our  ultimate  goal  is  to  make  DBT  an  even  more  effective  tool  for  breast  cancer  screening  and  diagnosis.    In  this  thesis,  we  first  developed  a  deep  convolutional  neural  network  (DCNN)  for  denoising  reconstructed  DBT  images.  We  trained  the  DCNN  using  a  weighted  combination  of  mean  squared  error  loss  and  the  adversarial  loss  based  on  generative  adversarial  network  (GAN),  and  therefore  called  it  DNGAN.  The  DNGAN  improved  the  contrast-to-noise  ratio,  detectability  index,  and  human  observer  detection  sensitivity  of  the  MCs  in  DBT  images  of  breast  simulating  phantoms.  Promising  denoising  results  were  also  observed  on  a  small  test  set  of  human  subject  DBTs.  Then,  we  introduced  a  model-based  DCNN-regularized  reconstruction  (MDR)  method  for  DBT.  It  combined  a  model-based  iterative  reconstruction  method  with  the  DNGAN  denoiser.  To  facilitate  task-based  image  quality  assessment,  we  also  proposed  two  DCNN  tools:  CNN-NE  for  noise  estimation,  and  CNN-MC  as  a  model  observer  for  MC  cluster  detectability  measure.  We  demonstrated  the  effectiveness  of  CNN-NE  and  CNN-MC  using  phantom  DBTs.  The  MDR  method  achieved  low  noise  and  the  highest  detection  rankings  on  a  test  set  of  human  subject  DBTs.  Finally,  we  presented  our  work  on  modeling  the  x-ray  source  motion  blur  of  the  DBT  imaging  system.  We  derived  an  analytical  in-plane  source  blur  kernel  for  DBT  images  based  on  imaging  geometry  and  showed  that  it  could  be  approximated  by  a  shift-invariant  kernel  over  the  DBT  slice  at  a  given  height  above  the  detector.  We  proposed  a  post-processing  image  deblurring  method  with  a  generative  diffusion  model  as  an  image  prior  and  successfully  enhanced  spatial  resolution  of  the  reconstructed  DBT  images.
■590    ▼aSchool  code:  0127.
■650  4▼aBiomedical  engineering
■650  4▼aComputer  science
■650  4▼aElectrical  engineering
■650  4▼aComputer  engineering
■653    ▼aDigital  breast  tomosynthesis
■653    ▼aImage  reconstruction
■653    ▼aDeep  learning
■653    ▼aImage  processing
■653    ▼aMicrocalcification
■653    ▼aImage  quality  evaluation
■690    ▼a0544
■690    ▼a0541
■690    ▼a0984
■690    ▼a0464
■71020▼aUniversity  of  Michigan▼bElectrical  and  Computer  Engineering.
■7730  ▼tDissertations  Abstracts  International▼g85-12B.
■790    ▼a0127
■791    ▼aPh.D.
■792    ▼a2024
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162844▼nKERIS▼z이  자료의  원문은  한국교육학술정보원에서  제공합니다.

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