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Effects of Oral Cancer Surgery on Upper Esophageal Opening During Swallowing
Effects of Oral Cancer Surgery on Upper Esophageal Opening During Swallowing
Detailed Information
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211153121
- ISBN
- 9798346849278
- DDC
- 616.8
- 저자명
- Knigge, Molly A.
- 서명/저자
- Effects of Oral Cancer Surgery on Upper Esophageal Opening During Swallowing
- 발행사항
- [Sl] : The University of Wisconsin - Madison, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 139 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-06, Section: A.
- 주기사항
- Advisor: Thibeault, Susan.
- 학위논문주기
- Thesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
- 초록/해제
- 요약Background: Improved survival following oral cancer remains threatened by reduced quality of life and poor health outcomes related to swallowing dysfunction. Dysphagia following surgery includes reduced upper esophageal sphincter opening, though no treatment standards have been established. Two studies conducted aimed to: 1) compare measures of UES function in post-operative oral cancer patients to normative measures, and 2) examine relationships between UES function and swallowing-related outcomes.Methods: Patients with oral cancer were recruited following surgical resection of tongue or floor of mouth and underwent concurrent videofluoroscopic swallow study and high-resolution pharyngeal manometry. Swallowing outcomes were collected using the M.D. Anderson Dysphagia Inventory and Dynamic Imaging Grade of Swallowing Toxicity. Consented participants were age- and sex-matched to healthy adult videofluoroscopic and manometric data. The second study extracted oncologic data from a head and neck cancer database and electronic medical record. Automated analysis was used to derive UES and pharyngeal manometry metrics, while videofluoroscopic imaging was analyzed using the Analysis of Swallowing Physiology: Events, Kinematics and Timing method. Results: Prospective data were collected from four patient participants and compared to controls, while retrospective data identified 23 studies eligible for analysis. No significant difference was found in UES maximum admittance between participants with oral cancer and controls (p = 0.1312), nor were other manometric UES measures found to differ significantly. Mean global pharyngeal contractile integrals following surgery were significantly lower than controls (p = 0.0230). In controls with lifestyle risk factors, peak hyoid position did not significantly differ from oral cancer patients. In retrospective analysis, median peak hyoid excursion (p = 0.0102), UES diameter (p = 0.0114), and pharyngeal residue area (p 0.0001) were significantly different from healthy reference values (Steele et al., 2023). Neither study showed significant relationships between UES function and patient-rated or clinician-rated swallowing outcomes. Conclusions: Measures of UES function following oral cancer surgery showed no relationship to swallowing outcomes prior to adjuvant radiotherapy. Manometric measures of global pharyngeal function, however, remained significantly reduced at one month after surgery. These findings suggest that future research focused on pharyngeal pressure generation and efficiency may better target post-operative treatment approaches.
- 일반주제명
- Speech therapy
- 일반주제명
- Oncology
- 일반주제명
- Therapy
- 일반주제명
- Surgery
- 일반주제명
- Medical imaging
- 키워드
- Dysphagia
- 키워드
- Manometry
- 키워드
- Oral cancer
- 키워드
- Videofluoroscopy
- 기타저자
- The University of Wisconsin - Madison Clinical Investigation - MED
- 기본자료저록
- Dissertations Abstracts International. 86-06A.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211153121
■006m o d
■007cr#unu||||||||
■020 ▼a9798346849278
■035 ▼a(MiAaPQ)AAI31763341
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616.8
■1001 ▼aKnigge, Molly A.
■24510▼aEffects of Oral Cancer Surgery on Upper Esophageal Opening During Swallowing
■260 ▼a[Sl]▼bThe University of Wisconsin - Madison▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a139 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-06, Section: A.
■500 ▼aAdvisor: Thibeault, Susan.
■5021 ▼aThesis (Ph.D.)--The University of Wisconsin - Madison, 2024.
■520 ▼aBackground: Improved survival following oral cancer remains threatened by reduced quality of life and poor health outcomes related to swallowing dysfunction. Dysphagia following surgery includes reduced upper esophageal sphincter opening, though no treatment standards have been established. Two studies conducted aimed to: 1) compare measures of UES function in post-operative oral cancer patients to normative measures, and 2) examine relationships between UES function and swallowing-related outcomes.Methods: Patients with oral cancer were recruited following surgical resection of tongue or floor of mouth and underwent concurrent videofluoroscopic swallow study and high-resolution pharyngeal manometry. Swallowing outcomes were collected using the M.D. Anderson Dysphagia Inventory and Dynamic Imaging Grade of Swallowing Toxicity. Consented participants were age- and sex-matched to healthy adult videofluoroscopic and manometric data. The second study extracted oncologic data from a head and neck cancer database and electronic medical record. Automated analysis was used to derive UES and pharyngeal manometry metrics, while videofluoroscopic imaging was analyzed using the Analysis of Swallowing Physiology: Events, Kinematics and Timing method. Results: Prospective data were collected from four patient participants and compared to controls, while retrospective data identified 23 studies eligible for analysis. No significant difference was found in UES maximum admittance between participants with oral cancer and controls (p = 0.1312), nor were other manometric UES measures found to differ significantly. Mean global pharyngeal contractile integrals following surgery were significantly lower than controls (p = 0.0230). In controls with lifestyle risk factors, peak hyoid position did not significantly differ from oral cancer patients. In retrospective analysis, median peak hyoid excursion (p = 0.0102), UES diameter (p = 0.0114), and pharyngeal residue area (p 0.0001) were significantly different from healthy reference values (Steele et al., 2023). Neither study showed significant relationships between UES function and patient-rated or clinician-rated swallowing outcomes. Conclusions: Measures of UES function following oral cancer surgery showed no relationship to swallowing outcomes prior to adjuvant radiotherapy. Manometric measures of global pharyngeal function, however, remained significantly reduced at one month after surgery. These findings suggest that future research focused on pharyngeal pressure generation and efficiency may better target post-operative treatment approaches.
■590 ▼aSchool code: 0262.
■650 4▼aSpeech therapy
■650 4▼aOncology
■650 4▼aTherapy
■650 4▼aSurgery
■650 4▼aMedical imaging
■653 ▼aDysphagia
■653 ▼aHead and neck surgery
■653 ▼aManometry
■653 ▼aOral cancer
■653 ▼aVideofluoroscopy
■690 ▼a0460
■690 ▼a0576
■690 ▼a0574
■690 ▼a0992
■690 ▼a0212
■71020▼aThe University of Wisconsin - Madison▼bClinical Investigation - MED.
■7730 ▼tDissertations Abstracts International▼g86-06A.
■790 ▼a0262
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17165084▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
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