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Navigating the Spinal Skeletal Stem Cell Microenvironment: Insights for Targeted Tissue Regeneration
Navigating the Spinal Skeletal Stem Cell Microenvironment: Insights for Targeted Tissue Regeneration
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151405
- ISBN
- 9798382230863
- DDC
- 612
- 서명/저자
- Navigating the Spinal Skeletal Stem Cell Microenvironment: Insights for Targeted Tissue Regeneration
- 발행사항
- [Sl] : Stanford University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 201 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Longaker, Michael.
- 학위논문주기
- Thesis (Ph.D.)--Stanford University, 2024.
- 초록/해제
- 요약The intervertebral disc (IVD), also known as the spinal disc, undergoes accelerated degeneration compared to other connective tissues, leading to intervertebral disc degeneration. Addressing this challenge requires effective treatments capable of reversing fibrocartilage damage caused by factors such as age and injury. Tissue-resident stem cells hold promise for IVD treatment due to their self-renewal and differentiation properties. In this dissertation, I will discuss our efforts to identify novel regulators of spinal skeletal stem cell (SSC) differentiation and their role in regenerating IVD tissue in response to injury. Additionally, I will outline a protocol we developed for isolating and functionally assessing human SSCs from various cell and tissue sources. Our basic and preclinical findings lay the foundation for innovative stem cell-based therapies targeting IVD degeneration and other related disorders.
- 일반주제명
- Physiology
- 일반주제명
- Cellular biology
- 일반주제명
- Molecular biology
- 키워드
- IVD treatment
- 키워드
- IVD degeneration
- 기타저자
- Stanford University.
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
008250123s2024 us c eng d■001000017161508
■00520250211151405
■006m o d
■007cr#unu||||||||
■020 ▼a9798382230863
■035 ▼a(MiAaPQ)AAI31255821
■035 ▼a(MiAaPQ)vq576bb4130
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a612
■1001 ▼aMalachia Yvonne Hoover.
■24510▼aNavigating the Spinal Skeletal Stem Cell Microenvironment: Insights for Targeted Tissue Regeneration
■260 ▼a[Sl]▼bStanford University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a201 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Longaker, Michael.
■5021 ▼aThesis (Ph.D.)--Stanford University, 2024.
■520 ▼aThe intervertebral disc (IVD), also known as the spinal disc, undergoes accelerated degeneration compared to other connective tissues, leading to intervertebral disc degeneration. Addressing this challenge requires effective treatments capable of reversing fibrocartilage damage caused by factors such as age and injury. Tissue-resident stem cells hold promise for IVD treatment due to their self-renewal and differentiation properties. In this dissertation, I will discuss our efforts to identify novel regulators of spinal skeletal stem cell (SSC) differentiation and their role in regenerating IVD tissue in response to injury. Additionally, I will outline a protocol we developed for isolating and functionally assessing human SSCs from various cell and tissue sources. Our basic and preclinical findings lay the foundation for innovative stem cell-based therapies targeting IVD degeneration and other related disorders.
■590 ▼aSchool code: 0212.
■650 4▼aPhysiology
■650 4▼aCellular biology
■650 4▼aMolecular biology
■653 ▼aSkeletal stem cell
■653 ▼aIntervertebral disc
■653 ▼aIVD treatment
■653 ▼aIVD degeneration
■690 ▼a0379
■690 ▼a0307
■690 ▼a0719
■71020▼aStanford University.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0212
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161508▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
