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Ordering of DNA-Coated Colloids in Concentrated Electrolytes: X-Ray Scattering Studies
Ordering of DNA-Coated Colloids in Concentrated Electrolytes: X-Ray Scattering Studies
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151420
- ISBN
- 9798382761961
- DDC
- 530
- 서명/저자
- Ordering of DNA-Coated Colloids in Concentrated Electrolytes: X-Ray Scattering Studies
- 발행사항
- [Sl] : Northwestern University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 211 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Bedzyk, Michael J.
- 학위논문주기
- Thesis (Ph.D.)--Northwestern University, 2024.
- 초록/해제
- 요약Liquid electrolytes lie at the heart of a plethora of critical technologies and mediate the biochemical processes that underpin life. Despite this ubiquity, comprehensive descriptions of these materials remain elusive, owing to the complex interplay between collective short-and-long-ranged interactions governing ions and solvent molecules. Interactions between highly charged macromolecules and concentrated electrolytes are particularly challenging, as the distributions of mobile ions are necessarily dictated by a combination of the electric fields of the macromolecular surface and those of neighboring ions. Model experimental systems are necessary to detect both the presence and functional significance of such "ion-ion correlations" in high-salt conditions. To address this need, this thesis investigates the assembly DNA-grafted nanoparticles in concentrated aqueous salt solutions, with the goal of elucidating the relationships between the molecular-scale interactions within the electrolyte to the mesoscopic responses of the highly charged nanoscale probes. Experimental measurements, including X-ray, neutron, and visible light scattering, are combined with molecular dynamic simulations to achieve a rigorous description of this system across a wide range of length scales. Of particular interest are attractive forces between DNA molecules manifested by divalent cations, which induce the formation of colloidal crystals; these ion-driven forces evolve considerably as salt concentration is elevated, resulting in considerable structural evolution of the nanoparticle assemblies. The influences of macromolecular solvation and ion-ion correlations are deduced, and these understandings are utilized to characterize more complex systems, such as mixtures of salts and temperature-varying conditions. These results serve to inform future theories of electrolytes and outline phenomena pertinent to biology and nanotechnology.
- 일반주제명
- Physics
- 일반주제명
- Physical chemistry
- 일반주제명
- Materials science
- 일반주제명
- Genetics
- 일반주제명
- Biophysics
- 키워드
- Colloids
- 키워드
- DNA
- 키워드
- Electrolytes
- 키워드
- Electrostatics
- 키워드
- Salting-out
- 기타저자
- Northwestern University Materials Science and Engineering
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151420
■006m o d
■007cr#unu||||||||
■020 ▼a9798382761961
■035 ▼a(MiAaPQ)AAI31294118
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a530
■1001 ▼aReinertsen, Roger J. E.▼0(orcid)0000-0003-2869-2961
■24510▼aOrdering of DNA-Coated Colloids in Concentrated Electrolytes: X-Ray Scattering Studies
■260 ▼a[Sl]▼bNorthwestern University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a211 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Bedzyk, Michael J.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2024.
■520 ▼aLiquid electrolytes lie at the heart of a plethora of critical technologies and mediate the biochemical processes that underpin life. Despite this ubiquity, comprehensive descriptions of these materials remain elusive, owing to the complex interplay between collective short-and-long-ranged interactions governing ions and solvent molecules. Interactions between highly charged macromolecules and concentrated electrolytes are particularly challenging, as the distributions of mobile ions are necessarily dictated by a combination of the electric fields of the macromolecular surface and those of neighboring ions. Model experimental systems are necessary to detect both the presence and functional significance of such "ion-ion correlations" in high-salt conditions. To address this need, this thesis investigates the assembly DNA-grafted nanoparticles in concentrated aqueous salt solutions, with the goal of elucidating the relationships between the molecular-scale interactions within the electrolyte to the mesoscopic responses of the highly charged nanoscale probes. Experimental measurements, including X-ray, neutron, and visible light scattering, are combined with molecular dynamic simulations to achieve a rigorous description of this system across a wide range of length scales. Of particular interest are attractive forces between DNA molecules manifested by divalent cations, which induce the formation of colloidal crystals; these ion-driven forces evolve considerably as salt concentration is elevated, resulting in considerable structural evolution of the nanoparticle assemblies. The influences of macromolecular solvation and ion-ion correlations are deduced, and these understandings are utilized to characterize more complex systems, such as mixtures of salts and temperature-varying conditions. These results serve to inform future theories of electrolytes and outline phenomena pertinent to biology and nanotechnology.
■590 ▼aSchool code: 0163.
■650 4▼aPhysics
■650 4▼aPhysical chemistry
■650 4▼aMaterials science
■650 4▼aGenetics
■650 4▼aBiophysics
■653 ▼aColloids
■653 ▼aDNA
■653 ▼aElectrolytes
■653 ▼aElectrostatics
■653 ▼aSalting-out
■690 ▼a0794
■690 ▼a0605
■690 ▼a0494
■690 ▼a0786
■690 ▼a0369
■71020▼aNorthwestern University▼bMaterials Science and Engineering.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161610▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
