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Examining the Effects of Prenatal Urinary Lead on Child Outcomes in Context
Examining the Effects of Prenatal Urinary Lead on Child Outcomes in Context
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151134
- ISBN
- 9798382719016
- DDC
- 136
- 서명/저자
- Examining the Effects of Prenatal Urinary Lead on Child Outcomes in Context
- 발행사항
- [Sl] : The University of North Carolina at Chapel Hill, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 222 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
- 주기사항
- Advisor: Propper, Cathi B.
- 학위논문주기
- Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.
- 초록/해제
- 요약Though lead is a well-known neurotoxicant, extant studies examining the associations of prenatal lead on offspring cognitive and socioemotional functioning have been inconsistent in their observed affected domains, suggesting that contextual factors may modify the toxicity of lead on fetal neurodevelopment (Bellinger, 1995). This compilation of studies explores how social and physiological contextual factors co-occur with prenatal lead exposure and may contribute to the heterogeneity of the associations of prenatal lead on child outcomes. This project relies on data from the Brain and Early Experience (BEE) Study, an analytic cohort of 201 mother-child dyads participating from mid-pregnancy through early childhood. I examine associations between prenatal urinary lead and child language, effortful control, and negative affect within three contexts: the prenatal social context (Study 1), a prenatal physiological context (Study 2), and a postnatal social context (Study 3). In Study 1, I explored latent profiles of prenatal exposure to lead and socioeconomic, psychological, and physical health stressors. I uncovered three prenatal latent profiles, characterized as psychologically stressed, socioeconomically stressed, and advantaged, and I found that prenatal latent profile membership was differentially related to children's early language skills and negative affect. In Study 2, I tested whether maternal prenatal microbiota diversity mediates or moderates the associations of prenatal urinary lead on child outcomes. I found weak evidence that prenatal lead predicted higher microbiota diversity and that the negative association of prenatal lead on child language was conditional upon mothers having high prenatal microbiota diversity. In Study 3, I examined whether positive caregiving or cognitive enrichment experienced in infancy could buffer the associations of prenatal lead on child outcomes. Results revealed that high cognitive enrichment postnatally mitigated the associations of prenatal lead on early child language skills. Within this perinatal cohort, lead exposure and its moderators, microbiota diversity and cognitive enrichment, were not highly correlated with socioeconomic indicators. Findings from these studies can inspire future research and intervention efforts into how social and physiological contextual factors could be leveraged to buffer the toxic effects of prenatal lead on fetal neurodevelopment.
- 일반주제명
- Developmental psychology
- 일반주제명
- Neurosciences
- 일반주제명
- Psychology
- 일반주제명
- Pediatrics
- 키워드
- Language skills
- 키워드
- Lead exposure
- 키워드
- Temperament
- 기타저자
- The University of North Carolina at Chapel Hill Psychology
- 기본자료저록
- Dissertations Abstracts International. 85-11B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151134
■006m o d
■007cr#unu||||||||
■020 ▼a9798382719016
■035 ▼a(MiAaPQ)AAI31147970
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a136
■1001 ▼aWylie, Amanda Catherine.
■24510▼aExamining the Effects of Prenatal Urinary Lead on Child Outcomes in Context
■260 ▼a[Sl]▼bThe University of North Carolina at Chapel Hill▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a222 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-11, Section: B.
■500 ▼aAdvisor: Propper, Cathi B.
■5021 ▼aThesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.
■520 ▼aThough lead is a well-known neurotoxicant, extant studies examining the associations of prenatal lead on offspring cognitive and socioemotional functioning have been inconsistent in their observed affected domains, suggesting that contextual factors may modify the toxicity of lead on fetal neurodevelopment (Bellinger, 1995). This compilation of studies explores how social and physiological contextual factors co-occur with prenatal lead exposure and may contribute to the heterogeneity of the associations of prenatal lead on child outcomes. This project relies on data from the Brain and Early Experience (BEE) Study, an analytic cohort of 201 mother-child dyads participating from mid-pregnancy through early childhood. I examine associations between prenatal urinary lead and child language, effortful control, and negative affect within three contexts: the prenatal social context (Study 1), a prenatal physiological context (Study 2), and a postnatal social context (Study 3). In Study 1, I explored latent profiles of prenatal exposure to lead and socioeconomic, psychological, and physical health stressors. I uncovered three prenatal latent profiles, characterized as psychologically stressed, socioeconomically stressed, and advantaged, and I found that prenatal latent profile membership was differentially related to children's early language skills and negative affect. In Study 2, I tested whether maternal prenatal microbiota diversity mediates or moderates the associations of prenatal urinary lead on child outcomes. I found weak evidence that prenatal lead predicted higher microbiota diversity and that the negative association of prenatal lead on child language was conditional upon mothers having high prenatal microbiota diversity. In Study 3, I examined whether positive caregiving or cognitive enrichment experienced in infancy could buffer the associations of prenatal lead on child outcomes. Results revealed that high cognitive enrichment postnatally mitigated the associations of prenatal lead on early child language skills. Within this perinatal cohort, lead exposure and its moderators, microbiota diversity and cognitive enrichment, were not highly correlated with socioeconomic indicators. Findings from these studies can inspire future research and intervention efforts into how social and physiological contextual factors could be leveraged to buffer the toxic effects of prenatal lead on fetal neurodevelopment.
■590 ▼aSchool code: 0153.
■650 4▼aDevelopmental psychology
■650 4▼aNeurosciences
■650 4▼aPsychology
■650 4▼aPediatrics
■653 ▼aDevelopmental origins
■653 ▼aFetal neurodevelopment
■653 ▼aLanguage skills
■653 ▼aLead exposure
■653 ▼aTemperament
■690 ▼a0620
■690 ▼a0621
■690 ▼a0767
■690 ▼a0317
■71020▼aThe University of North Carolina at Chapel Hill▼bPsychology.
■7730 ▼tDissertations Abstracts International▼g85-11B.
■790 ▼a0153
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160905▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
