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Spatiotemporal Dynamics, Neural Circuitry, and Environmental Context of Decision-Making in Drosophila melanogaster
Spatiotemporal Dynamics, Neural Circuitry, and Environmental Context of Decision-Making in Drosophila melanogaster
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152802
- ISBN
- 9798346567776
- DDC
- 616
- 저자명
- Alisch, Tom.
- 서명/저자
- Spatiotemporal Dynamics, Neural Circuitry, and Environmental Context of Decision-Making in Drosophila melanogaster
- 발행사항
- [Sl] : Harvard University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 170 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
- 주기사항
- Advisor: de Bivort, Benjamin.
- 학위논문주기
- Thesis (Ph.D.)--Harvard University, 2024.
- 초록/해제
- 요약My thesis examines the intricate dynamics of decision-making in Drosophila melanogaster across three different contexts. In Chapter 1, I investigate how locomotor decisions progress through time and space. I show that turning decisions in Y-mazes occur earlier than previously believed, that local geometry plays a critical role in shaping the course of a decision, and that future turns can be predicted by past locomotor behavior. Further, I show that this predictability is under control of both external and internal information processing, using sensory and information-processing mutants, and simulated model flies. Last, I present evidence that this novel approach of describing decision-making by its spatial and temporal dynamics is generalizable to human participants in a virtual Y-maze. In Chapter 2, I identify a key neuron pair involved in phototactic decision-making, and propose a neural circuit underlying modulable phototaxis. In Chapter 3, I explore decision-making of truly wild flies in nature using the ACORN robotic platform. l show that there exist behavioral idiosyncrasies in truly wild flies similar to lab-reared flies. Finally, I present evidence for day-to-day fluctuations and seasonal changes in higher order locomotor behavior features.
- 일반주제명
- Neurosciences
- 일반주제명
- Biology
- 일반주제명
- Genetics
- 일반주제명
- Robotics
- 키워드
- Decision-making
- 키워드
- Environment
- 키워드
- Genes
- 기타저자
- Harvard University Biology Organismic and Evolutionary
- 기본자료저록
- Dissertations Abstracts International. 86-05B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■007cr#unu||||||||
■020 ▼a9798346567776
■035 ▼a(MiAaPQ)AAI31556755
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a616
■1001 ▼aAlisch, Tom.▼0(orcid)0000-0001-7884-7031
■24510▼aSpatiotemporal Dynamics, Neural Circuitry, and Environmental Context of Decision-Making in Drosophila melanogaster
■260 ▼a[Sl]▼bHarvard University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a170 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-05, Section: B.
■500 ▼aAdvisor: de Bivort, Benjamin.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2024.
■520 ▼aMy thesis examines the intricate dynamics of decision-making in Drosophila melanogaster across three different contexts. In Chapter 1, I investigate how locomotor decisions progress through time and space. I show that turning decisions in Y-mazes occur earlier than previously believed, that local geometry plays a critical role in shaping the course of a decision, and that future turns can be predicted by past locomotor behavior. Further, I show that this predictability is under control of both external and internal information processing, using sensory and information-processing mutants, and simulated model flies. Last, I present evidence that this novel approach of describing decision-making by its spatial and temporal dynamics is generalizable to human participants in a virtual Y-maze. In Chapter 2, I identify a key neuron pair involved in phototactic decision-making, and propose a neural circuit underlying modulable phototaxis. In Chapter 3, I explore decision-making of truly wild flies in nature using the ACORN robotic platform. l show that there exist behavioral idiosyncrasies in truly wild flies similar to lab-reared flies. Finally, I present evidence for day-to-day fluctuations and seasonal changes in higher order locomotor behavior features.
■590 ▼aSchool code: 0084.
■650 4▼aNeurosciences
■650 4▼aBiology
■650 4▼aGenetics
■650 4▼aRobotics
■653 ▼aDecision-making
■653 ▼aDrosophila melanogaster
■653 ▼aEnvironment
■653 ▼aGenes
■653 ▼aNeuronal circuitry
■690 ▼a0317
■690 ▼a0306
■690 ▼a0369
■690 ▼a0771
■71020▼aHarvard University▼bBiology, Organismic and Evolutionary.
■7730 ▼tDissertations Abstracts International▼g86-05B.
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17163863▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
