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Multiscale Biophysical Dynamics of Integrin Mechanosensing and Cell Adhesion In Silico
Multiscale Biophysical Dynamics of Integrin Mechanosensing and Cell Adhesion In Silico
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151425
- ISBN
- 9798384453079
- DDC
- 574.191
- 저자명
- Montes, Andre.
- 서명/저자
- Multiscale Biophysical Dynamics of Integrin Mechanosensing and Cell Adhesion In Silico
- 발행사항
- [Sl] : University of California, Berkeley, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 89 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
- 주기사항
- Advisor: Mofrad, Mohammad R. K.;O'Connell, Grace D.
- 학위논문주기
- Thesis (Ph.D.)--University of California, Berkeley, 2024.
- 초록/해제
- 요약Cells intricately sense mechanical forces from their surroundings, driving biophysical and biochemical activities. This phenomenon, known as mechanosensing, can occur at the cell-matrix interface. Here, mechanical forces resulting from cellular motion, such as migration or matrix stretching, are exchanged in part by the integrin receptor and its ligand, fibronectin. Upregulation of the α5β1 integrin-fibronectin bond is associated with uncontrolled cell metastasis. Therefore, the molecular mechanisms of this bond are of interest to control cell behavior and limit cancer cell spreading. This bond operates through catch bond dynamics, wherein the bond lifetime paradoxically increases with greater force. However, the mechanism sustaining the characteristic catch bond dynamics of the integrin-fibronectin bond remains unclear. The work presented here leveraged multiscale biophysical simulations to uncover the molecular mechanisms underpinning integrin-fibronectin's catch bond dynamics in the context of cell adhesion. This study integrated molecular dynamics simulations and finite element models to propose that fibronectin sites reinforce cell adhesion through enhanced binding properties and a mechanosensitive mechanism. This work sheds light on the mechanosensitive nature of cell-matrix interactions while contributing to our understanding of multiscale cellular behaviors in physiological and pathological environments.
- 일반주제명
- Biophysics
- 일반주제명
- Biomedical engineering
- 일반주제명
- Engineering
- 일반주제명
- Mechanical engineering
- 키워드
- Cell adhesion
- 기타저자
- University of California, Berkeley Mechanical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-03B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798384453079
■035 ▼a(MiAaPQ)AAI31294698
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574.191
■1001 ▼aMontes, Andre.
■24510▼aMultiscale Biophysical Dynamics of Integrin Mechanosensing and Cell Adhesion In Silico
■260 ▼a[Sl]▼bUniversity of California, Berkeley▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a89 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-03, Section: B.
■500 ▼aAdvisor: Mofrad, Mohammad R. K.;O'Connell, Grace D.
■5021 ▼aThesis (Ph.D.)--University of California, Berkeley, 2024.
■520 ▼aCells intricately sense mechanical forces from their surroundings, driving biophysical and biochemical activities. This phenomenon, known as mechanosensing, can occur at the cell-matrix interface. Here, mechanical forces resulting from cellular motion, such as migration or matrix stretching, are exchanged in part by the integrin receptor and its ligand, fibronectin. Upregulation of the α5β1 integrin-fibronectin bond is associated with uncontrolled cell metastasis. Therefore, the molecular mechanisms of this bond are of interest to control cell behavior and limit cancer cell spreading. This bond operates through catch bond dynamics, wherein the bond lifetime paradoxically increases with greater force. However, the mechanism sustaining the characteristic catch bond dynamics of the integrin-fibronectin bond remains unclear. The work presented here leveraged multiscale biophysical simulations to uncover the molecular mechanisms underpinning integrin-fibronectin's catch bond dynamics in the context of cell adhesion. This study integrated molecular dynamics simulations and finite element models to propose that fibronectin sites reinforce cell adhesion through enhanced binding properties and a mechanosensitive mechanism. This work sheds light on the mechanosensitive nature of cell-matrix interactions while contributing to our understanding of multiscale cellular behaviors in physiological and pathological environments.
■590 ▼aSchool code: 0028.
■650 4▼aBiophysics
■650 4▼aBiomedical engineering
■650 4▼aEngineering
■650 4▼aMechanical engineering
■653 ▼aBiochemical activities
■653 ▼aPathological environments
■653 ▼aCellular behaviors
■653 ▼aCell adhesion
■690 ▼a0786
■690 ▼a0541
■690 ▼a0537
■690 ▼a0548
■71020▼aUniversity of California, Berkeley▼bMechanical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-03B.
■790 ▼a0028
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161649▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
