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Efficient Generation of Primordial Germ Cells and CRISPR Perturbation Screens Identify Epigenetic Regulators Impacting Primordial Germ Cell Development
Efficient Generation of Primordial Germ Cells and CRISPR Perturbation Screens Identify Epigenetic Regulators Impacting Primordial Germ Cell Development
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151028
- ISBN
- 9798382840239
- DDC
- 574
- 저자명
- Li, Liangdao.
- 서명/저자
- Efficient Generation of Primordial Germ Cells and CRISPR Perturbation Screens Identify Epigenetic Regulators Impacting Primordial Germ Cell Development
- 발행사항
- [Sl] : Cornell University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 165 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Schimenti, John.
- 학위논문주기
- Thesis (Ph.D.)--Cornell University, 2024.
- 초록/해제
- 요약In mammalian development, the process of gametogenesis begins with a group of germline precursors known as primordial germ cells (PGCs), which emerge shortly after embryo implantation. These PGCs undertake a migration through the developing hindgut to ultimately reach and populate the embryonic gonads. In vitro modeling of this complex developmental process offers a non-invasive method to study the molecular mechanisms governing gametogenesis. This is particularly significant for understanding the genetic and epigenetic underpinnings of infertility, which can inform advancements in assisted reproductive technologies (ART), including gene correction techniques and the optimization of in vitro gametogenesis (IVG). My thesis will concentrate on refining this in vitro model for generating mouse PGCs, aiming to make the process more efficient and scalable. An important aspect of my research will involve utilizing CRISPR technology for perturbation screens, designed to identify key epigenetic regulators that play a crucial role in PGC development. By enhancing our understanding of these regulators and the overall process of PGC development, my research could provide valuable insights and tools for improving ART and IVG.
- 일반주제명
- Biology
- 일반주제명
- Cellular biology
- 일반주제명
- Genetics
- 키워드
- Infertility
- 기타저자
- Cornell University Biomedical and Biological Sciences
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■1001 ▼aLi, Liangdao.▼0(orcid)0000-0001-9266-5103
■24510▼aEfficient Generation of Primordial Germ Cells and CRISPR Perturbation Screens Identify Epigenetic Regulators Impacting Primordial Germ Cell Development
■260 ▼a[Sl]▼bCornell University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a165 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Schimenti, John.
■5021 ▼aThesis (Ph.D.)--Cornell University, 2024.
■520 ▼aIn mammalian development, the process of gametogenesis begins with a group of germline precursors known as primordial germ cells (PGCs), which emerge shortly after embryo implantation. These PGCs undertake a migration through the developing hindgut to ultimately reach and populate the embryonic gonads. In vitro modeling of this complex developmental process offers a non-invasive method to study the molecular mechanisms governing gametogenesis. This is particularly significant for understanding the genetic and epigenetic underpinnings of infertility, which can inform advancements in assisted reproductive technologies (ART), including gene correction techniques and the optimization of in vitro gametogenesis (IVG). My thesis will concentrate on refining this in vitro model for generating mouse PGCs, aiming to make the process more efficient and scalable. An important aspect of my research will involve utilizing CRISPR technology for perturbation screens, designed to identify key epigenetic regulators that play a crucial role in PGC development. By enhancing our understanding of these regulators and the overall process of PGC development, my research could provide valuable insights and tools for improving ART and IVG.
■590 ▼aSchool code: 0058.
■650 4▼aBiology
■650 4▼aCellular biology
■650 4▼aGenetics
■653 ▼aAssisted reproductive technologies
■653 ▼aPrimordial germ cells
■653 ▼aInfertility
■653 ▼aGametogenesis begins
■653 ▼aEpigenetic regulators
■690 ▼a0306
■690 ▼a0379
■690 ▼a0369
■71020▼aCornell University▼bBiomedical and Biological Sciences.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0058
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17160487▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
