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Organic Bioelectronics for Bio-Inspired Sensor Design
Organic Bioelectronics for Bio-Inspired Sensor Design
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151509
- ISBN
- 9798384018261
- DDC
- 610
- 서명/저자
- Organic Bioelectronics for Bio-Inspired Sensor Design
- 발행사항
- [Sl] : Northwestern University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 233 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
- 주기사항
- Advisor: Rivnay, Jonathan.
- 학위논문주기
- Thesis (Ph.D.)--Northwestern University, 2024.
- 초록/해제
- 요약Bioelectronic devices have made significant contributions to our understanding and treatment of the human body but remain limited by mechanical mismatch and poor signal transduction at the biotic/abiotic interface. Organic mixed ionic-electronic conductors (OMIECs) can build soft, intimate interfaces with biology by translating ionic fluxes from living systems into an electronic current compatible with traditional microelectronics. This class of polymers gives bioelectronics a low electrochemical impedance, enabling sensing of small, otherwise undetectable biological signals. An emerging strategy for biosensor design leverages transmembrane proteins found in cell membranes to drive analyte detection. OMIECs are well-poised to improve these devices because their high biocompatibility and soft mechanics allow them to cushion functional fluid membranes. Combining advances in bioelectronics and synthetic biology therefore generates a new platform that acts both as a tool for mechanistic study of membrane processes and also as a bio-inspired sensor with the same sensing mechanisms as living cells. This thesis addresses challenges in polymer science, device fabrication, lipid and hybrid bilayer formation, and protein engineering to successfully integrate model membranes with organic bioelectronics. In particular, sensor stability and reproducibility are enhanced through tuning of OMIEC properties, lipid composition, and via the class of model membrane. First, I will highlight the shortcomings of current sensor designs based on OMIEC selection and investigate the generalizable sources and mechanism of performance degradation for transistors using polythiophene-based OMIECs. Next, I will demonstrate that supported lipid bilayers on OMIEC electronics can be assembled with blends of phospholipids and synthetic block copolymers to establish membranes with tunable biophysical properties and increased resilience to environmental interferents. Subsequently, I will initiate the first example of droplet bilayers supported by OMIECs to further promote membrane sensor stability and reliability and I will demonstrate integration with microfabricated OMIEC electronic devices and gated membrane proteins. Broadly, the sensors constructed throughout this thesis sustain high integrity membranes with strong electrical sealing and support complex transmembrane proteins sensitive to a range of biological stimuli. This work represents significant progress toward realizing the full potential of organic mixed conductors as biological interfaces and establishing these bio-inspired sensors as an exciting new platform with unique translational promise.
- 일반주제명
- Biomedical engineering
- 일반주제명
- Nanotechnology
- 일반주제명
- Biomechanics
- 키워드
- Bioelectronics
- 키워드
- Cell membranes
- 키워드
- Sensors
- 기타저자
- Northwestern University Biomedical Engineering
- 기본자료저록
- Dissertations Abstracts International. 86-02B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■00520250211151509
■006m o d
■007cr#unu||||||||
■020 ▼a9798384018261
■035 ▼a(MiAaPQ)AAI31299428
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aSchafer, Emily A.
■24510▼aOrganic Bioelectronics for Bio-Inspired Sensor Design
■260 ▼a[Sl]▼bNorthwestern University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a233 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-02, Section: B.
■500 ▼aAdvisor: Rivnay, Jonathan.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2024.
■520 ▼aBioelectronic devices have made significant contributions to our understanding and treatment of the human body but remain limited by mechanical mismatch and poor signal transduction at the biotic/abiotic interface. Organic mixed ionic-electronic conductors (OMIECs) can build soft, intimate interfaces with biology by translating ionic fluxes from living systems into an electronic current compatible with traditional microelectronics. This class of polymers gives bioelectronics a low electrochemical impedance, enabling sensing of small, otherwise undetectable biological signals. An emerging strategy for biosensor design leverages transmembrane proteins found in cell membranes to drive analyte detection. OMIECs are well-poised to improve these devices because their high biocompatibility and soft mechanics allow them to cushion functional fluid membranes. Combining advances in bioelectronics and synthetic biology therefore generates a new platform that acts both as a tool for mechanistic study of membrane processes and also as a bio-inspired sensor with the same sensing mechanisms as living cells. This thesis addresses challenges in polymer science, device fabrication, lipid and hybrid bilayer formation, and protein engineering to successfully integrate model membranes with organic bioelectronics. In particular, sensor stability and reproducibility are enhanced through tuning of OMIEC properties, lipid composition, and via the class of model membrane. First, I will highlight the shortcomings of current sensor designs based on OMIEC selection and investigate the generalizable sources and mechanism of performance degradation for transistors using polythiophene-based OMIECs. Next, I will demonstrate that supported lipid bilayers on OMIEC electronics can be assembled with blends of phospholipids and synthetic block copolymers to establish membranes with tunable biophysical properties and increased resilience to environmental interferents. Subsequently, I will initiate the first example of droplet bilayers supported by OMIECs to further promote membrane sensor stability and reliability and I will demonstrate integration with microfabricated OMIEC electronic devices and gated membrane proteins. Broadly, the sensors constructed throughout this thesis sustain high integrity membranes with strong electrical sealing and support complex transmembrane proteins sensitive to a range of biological stimuli. This work represents significant progress toward realizing the full potential of organic mixed conductors as biological interfaces and establishing these bio-inspired sensors as an exciting new platform with unique translational promise.
■590 ▼aSchool code: 0163.
■650 4▼aBiomedical engineering
■650 4▼aNanotechnology
■650 4▼aBiomechanics
■653 ▼aBioelectronics
■653 ▼aBioinspired sensor development
■653 ▼aConducting polymers
■653 ▼aCell membranes
■653 ▼aSensors
■690 ▼a0541
■690 ▼a0652
■690 ▼a0648
■71020▼aNorthwestern University▼bBiomedical Engineering.
■7730 ▼tDissertations Abstracts International▼g86-02B.
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161969▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
