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Deaminative Functionalizations of Primary Amines Enabled by Photoredox Catalysis
Deaminative Functionalizations of Primary Amines Enabled by Photoredox Catalysis
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211152022
- ISBN
- 9798383163795
- DDC
- 547
- 서명/저자
- Deaminative Functionalizations of Primary Amines Enabled by Photoredox Catalysis
- 발행사항
- [Sl] : Columbia University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 318 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: Rovis, Tomislav.
- 학위논문주기
- Thesis (Ph.D.)--Columbia University, 2024.
- 초록/해제
- 요약Utilizing primary amines as alkyl coupling partners has garnered attention in recent years due to their widespread availability, facile preparation and purification, and presence in a variety of common building blocks. The reemergence of Katritzky salts has enabled deaminative alkylation and arylation of α-1° and α-2° amines. The Rovis group has developed deaminative conditions for α-3° amines utilizing redox-active imines to generate tertiary carbon-centered radicals. Herein, we couple this tertiary alkyl radical to haloarenes to generate benzylic quaternary centers, a common motif in pharmaceuticals and natural products. We then applied this methodology in the realm of isotopic exchange to generate 15N-primary amines from their naturally occurring 14N-analogues. By activating α-1° and α-2° amines to Katritzky pyridinium salts and α−3° amines to redox-active imines, we can engage primary alkyl amines in a late-stage isotopic exchange with complete and selective isotopic labelling.
- 일반주제명
- Organic chemistry
- 일반주제명
- Chemistry
- 키워드
- Alkyl amines
- 기타저자
- Columbia University Chemistry
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798383163795
■035 ▼a(MiAaPQ)AAI31332422
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a547
■1001 ▼aDorsheimer, Julia R.
■24510▼aDeaminative Functionalizations of Primary Amines Enabled by Photoredox Catalysis
■260 ▼a[Sl]▼bColumbia University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a318 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Rovis, Tomislav.
■5021 ▼aThesis (Ph.D.)--Columbia University, 2024.
■520 ▼aUtilizing primary amines as alkyl coupling partners has garnered attention in recent years due to their widespread availability, facile preparation and purification, and presence in a variety of common building blocks. The reemergence of Katritzky salts has enabled deaminative alkylation and arylation of α-1° and α-2° amines. The Rovis group has developed deaminative conditions for α-3° amines utilizing redox-active imines to generate tertiary carbon-centered radicals. Herein, we couple this tertiary alkyl radical to haloarenes to generate benzylic quaternary centers, a common motif in pharmaceuticals and natural products. We then applied this methodology in the realm of isotopic exchange to generate 15N-primary amines from their naturally occurring 14N-analogues. By activating α-1° and α-2° amines to Katritzky pyridinium salts and α−3° amines to redox-active imines, we can engage primary alkyl amines in a late-stage isotopic exchange with complete and selective isotopic labelling.
■590 ▼aSchool code: 0054.
■650 4▼aOrganic chemistry
■650 4▼aChemistry
■653 ▼aDeaminative alkylation
■653 ▼aAlkyl amines
■653 ▼aPhotoredox catalysis
■690 ▼a0490
■690 ▼a0485
■71020▼aColumbia University▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0054
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162523▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
