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Alcohol Deoxygenation for the Synthesis of C(sp3) Rich Organic Molecules
Alcohol Deoxygenation for the Synthesis of C(sp3) Rich Organic Molecules
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211151442
- ISBN
- 9798382807638
- DDC
- 547
- 서명/저자
- Alcohol Deoxygenation for the Synthesis of C(sp3) Rich Organic Molecules
- 발행사항
- [Sl] : Princeton University, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 373 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- 주기사항
- Advisor: MacMillan, David W. C.
- 학위논문주기
- Thesis (Ph.D.)--Princeton University, 2024.
- 초록/해제
- 요약Synthetic methods that enable rapid construction of complex organic molecules from simple precursors are of paramount importance to human health. Given their structural diversity and ubiquity amongst a variety of natural sources, harnessing alcohols as starting materials in chemical synthesis would provide access to underexplored chemical space. In particular, cleavage of an alcohol C-O bond and subsequent formation of new C-C bonds represents a powerful strategy for complex molecule synthesis. Traditional deoxygenation protocols require harsh reaction conditions or laborious prefunctionalization that limits their utility. Photoredox catalysis has provided of a suite of methods for the cleavage of alcohol C-O bonds, including the discovery of benzoxazolium salts (termed NHCs) as in situ activating reagents.This thesis describes the utilization of these benzoxazolium salts to convert alcohols to C(sp3 )-CF3 and C(sp3 )-C(sp3 ) bonds. Chapter 2 discusses the conversion of alcohols to aliphatic trifluoromethyl groups by merging NHC deoxygenation with copper metallaphotoredox catalysis. Chapter 3 details a first of its kind cross alcohol coupling reaction that is enabled by combining NHC alcohol activation with the principles of SH2 radical sorting.
- 일반주제명
- Organic chemistry
- 일반주제명
- Chemistry
- 일반주제명
- Biochemistry
- 키워드
- Human health
- 키워드
- Alcohol
- 키워드
- Natural sources
- 기타저자
- Princeton University Chemistry
- 기본자료저록
- Dissertations Abstracts International. 85-12B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■020 ▼a9798382807638
■035 ▼a(MiAaPQ)AAI31296172
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a547
■1001 ▼aIntermaggio, Nicholas Edward.▼0(orcid)0009-0006-6193-6891
■24510▼aAlcohol Deoxygenation for the Synthesis of C(sp3) Rich Organic Molecules
■260 ▼a[Sl]▼bPrinceton University▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a373 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: MacMillan, David W. C.
■5021 ▼aThesis (Ph.D.)--Princeton University, 2024.
■520 ▼aSynthetic methods that enable rapid construction of complex organic molecules from simple precursors are of paramount importance to human health. Given their structural diversity and ubiquity amongst a variety of natural sources, harnessing alcohols as starting materials in chemical synthesis would provide access to underexplored chemical space. In particular, cleavage of an alcohol C-O bond and subsequent formation of new C-C bonds represents a powerful strategy for complex molecule synthesis. Traditional deoxygenation protocols require harsh reaction conditions or laborious prefunctionalization that limits their utility. Photoredox catalysis has provided of a suite of methods for the cleavage of alcohol C-O bonds, including the discovery of benzoxazolium salts (termed NHCs) as in situ activating reagents.This thesis describes the utilization of these benzoxazolium salts to convert alcohols to C(sp3 )-CF3 and C(sp3 )-C(sp3 ) bonds. Chapter 2 discusses the conversion of alcohols to aliphatic trifluoromethyl groups by merging NHC deoxygenation with copper metallaphotoredox catalysis. Chapter 3 details a first of its kind cross alcohol coupling reaction that is enabled by combining NHC alcohol activation with the principles of SH2 radical sorting.
■590 ▼aSchool code: 0181.
■650 4▼aOrganic chemistry
■650 4▼aChemistry
■650 4▼aBiochemistry
■653 ▼aHuman health
■653 ▼aBenzoxazolium salts
■653 ▼aAlcohol
■653 ▼aNatural sources
■653 ▼aDeoxygenation protocols
■690 ▼a0490
■690 ▼a0487
■690 ▼a0485
■71020▼aPrinceton University▼bChemistry.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0181
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17161765▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
