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Genomic and Environmental Predictors of Psychopathology Under Stress
Genomic and Environmental Predictors of Psychopathology Under Stress
상세정보
- 자료유형
- 학위논문 서양
- 최종처리일시
- 20250211153014
- ISBN
- 9798384045632
- DDC
- 150
- 서명/저자
- Genomic and Environmental Predictors of Psychopathology Under Stress
- 발행사항
- [Sl] : University of Michigan, 2024
- 발행사항
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- 형태사항
- 70 p
- 주기사항
- Source: Dissertations Abstracts International, Volume: 86-04, Section: B.
- 주기사항
- Advisor: Sen, Srijan.
- 학위논문주기
- Thesis (Ph.D.)--University of Michigan, 2024.
- 초록/해제
- 요약The overarching aim of this dissertation is to investigate independent and joint contributions of genetic factors and social environment in risk of psychopathology under a variety of stressful environments. In Study 1, we capitalize on recent advances in genomic technology and the measurement of social and environmental characteristics in two distinct populations to investigate gene x environment interactions in depressive symptoms. Here, we address the dissertation's Specific Aim 1: to test gene x environment interactions in predicting psychopathology under stress using polygenic risk scores for major depressive disorder (MDD). In Study 2, we characterize changes in depressive symptoms among frontline healthcare workers during the COVID-19 pandemic, and the associated changes in their work environments. Using causal mediation analysis, we address the dissertation's Specific Aim 2: to investigate trajectories of depressive symptoms during a global stressor, and identify potential sources of support for future intervention. In both studies, we apply advanced quantitative methods to large, longitudinal datasets to extend the literature on the potential causes of depressive symptoms. Taken together, these studies consider variability at the levels of genetics, individual and global psychosocial stressors, and interpersonal and institutional social support as they relate to the development of depressive symptoms.
- 일반주제명
- Psychology
- 일반주제명
- Clinical psychology
- 일반주제명
- Mental health
- 일반주제명
- Social psychology
- 일반주제명
- Genetics
- 키워드
- Depression risk
- 키워드
- Social support
- 기타저자
- University of Michigan Psychology
- 기본자료저록
- Dissertations Abstracts International. 86-04B.
- 전자적 위치 및 접속
- 로그인 후 원문을 볼 수 있습니다.
MARC
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■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a150
■1001 ▼aCleary, Jennifer.
■24510▼aGenomic and Environmental Predictors of Psychopathology Under Stress
■260 ▼a[Sl]▼bUniversity of Michigan▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a70 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-04, Section: B.
■500 ▼aAdvisor: Sen, Srijan.
■5021 ▼aThesis (Ph.D.)--University of Michigan, 2024.
■520 ▼aThe overarching aim of this dissertation is to investigate independent and joint contributions of genetic factors and social environment in risk of psychopathology under a variety of stressful environments. In Study 1, we capitalize on recent advances in genomic technology and the measurement of social and environmental characteristics in two distinct populations to investigate gene x environment interactions in depressive symptoms. Here, we address the dissertation's Specific Aim 1: to test gene x environment interactions in predicting psychopathology under stress using polygenic risk scores for major depressive disorder (MDD). In Study 2, we characterize changes in depressive symptoms among frontline healthcare workers during the COVID-19 pandemic, and the associated changes in their work environments. Using causal mediation analysis, we address the dissertation's Specific Aim 2: to investigate trajectories of depressive symptoms during a global stressor, and identify potential sources of support for future intervention. In both studies, we apply advanced quantitative methods to large, longitudinal datasets to extend the literature on the potential causes of depressive symptoms. Taken together, these studies consider variability at the levels of genetics, individual and global psychosocial stressors, and interpersonal and institutional social support as they relate to the development of depressive symptoms.
■590 ▼aSchool code: 0127.
■650 4▼aPsychology
■650 4▼aClinical psychology
■650 4▼aMental health
■650 4▼aSocial psychology
■650 4▼aGenetics
■653 ▼aDepression risk
■653 ▼aSocial support
■653 ▼aGenomic technology
■653 ▼aSocial environment
■653 ▼aCOVID-19 pandemic
■690 ▼a0621
■690 ▼a0622
■690 ▼a0347
■690 ▼a0369
■690 ▼a0451
■71020▼aUniversity of Michigan▼bPsychology.
■7730 ▼tDissertations Abstracts International▼g86-04B.
■790 ▼a0127
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164536▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
